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Assessment of LV myocardial function in aortic stenosis using personalized 3D+ time cardiac MRI modelling

Left ventricular hypertrophy (LVH) in aortic stenosis (AS) is known as an adaptive response affected by pressure overload as a result of the progressive narrowing of the aortic valve orifice. Both systolic and diastolic function of the left ventricular (LV) could be affected due to the structural re...

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Main Authors: Chuah, Shoon Hui, Thong, Wen Dee, Md Sari, Nor Ashikin, Tan, Li Kuo, Hasikin, Khairunnisa, Liew, Yih Miin
Format: Conference or Workshop Item
Published: Springer Science and Business Media Deutschland GmbH 2022
Subjects:
R Medicine
TA Engineering (General). Civil engineering (General)
Online Access:http://eprints.um.edu.my/43365/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85129333757&doi=10.1007%2f978-3-030-90724-2_46&partnerID=40&md5=104cf01b84b939438f4cc624e30c70db
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spelling my.um.eprints.433652025-02-12T04:31:55Z http://eprints.um.edu.my/43365/ Assessment of LV myocardial function in aortic stenosis using personalized 3D+ time cardiac MRI modelling Chuah, Shoon Hui Thong, Wen Dee Md Sari, Nor Ashikin Tan, Li Kuo Hasikin, Khairunnisa Liew, Yih Miin R Medicine TA Engineering (General). Civil engineering (General) Left ventricular hypertrophy (LVH) in aortic stenosis (AS) is known as an adaptive response affected by pressure overload as a result of the progressive narrowing of the aortic valve orifice. Both systolic and diastolic function of the left ventricular (LV) could be affected due to the structural remodelling as a sequel of AS. Therefore, this study utilized 3D+ time personalized LV modelling algorithm which was developed in-house to evaluate the LV function throughout the 20 cardiac phases of short- and long-axis cine MRI in different severity of AS patients. A total of 9 healthy cohorts and 13 AS patients with different degrees of severity were analyzed. This study demonstrated that majority of the AS patients have systolic dysfunction accompanied by deterioration of radial strain (RS) and longitudinal strain (LS) when compared against healthy cohorts (p < 0.05). Only those with concomitant concentric LVH (i.e. 38 of the AS patients) exhibited normal systolic and diastolic functions with a couple of exceptions observed. LVH was found developed in those with moderate and severe AS. No clear correlation was found between diastolic dysfunction and the severity of AS. © 2022, Springer Nature Switzerland AG. Springer Science and Business Media Deutschland GmbH 2022 Conference or Workshop Item PeerReviewed Chuah, Shoon Hui and Thong, Wen Dee and Md Sari, Nor Ashikin and Tan, Li Kuo and Hasikin, Khairunnisa and Liew, Yih Miin (2022) Assessment of LV myocardial function in aortic stenosis using personalized 3D+ time cardiac MRI modelling. In: 6th Kuala Lumpur International Conference on Biomedical Engineering, BioMed 2021, 28-29 July 2021, Virtual, Online. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85129333757&doi=10.1007%2f978-3-030-90724-2_46&partnerID=40&md5=104cf01b84b939438f4cc624e30c70db
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
TA Engineering (General). Civil engineering (General)
spellingShingle R Medicine
TA Engineering (General). Civil engineering (General)
Chuah, Shoon Hui
Thong, Wen Dee
Md Sari, Nor Ashikin
Tan, Li Kuo
Hasikin, Khairunnisa
Liew, Yih Miin
Assessment of LV myocardial function in aortic stenosis using personalized 3D+ time cardiac MRI modelling
description Left ventricular hypertrophy (LVH) in aortic stenosis (AS) is known as an adaptive response affected by pressure overload as a result of the progressive narrowing of the aortic valve orifice. Both systolic and diastolic function of the left ventricular (LV) could be affected due to the structural remodelling as a sequel of AS. Therefore, this study utilized 3D+ time personalized LV modelling algorithm which was developed in-house to evaluate the LV function throughout the 20 cardiac phases of short- and long-axis cine MRI in different severity of AS patients. A total of 9 healthy cohorts and 13 AS patients with different degrees of severity were analyzed. This study demonstrated that majority of the AS patients have systolic dysfunction accompanied by deterioration of radial strain (RS) and longitudinal strain (LS) when compared against healthy cohorts (p < 0.05). Only those with concomitant concentric LVH (i.e. 38 of the AS patients) exhibited normal systolic and diastolic functions with a couple of exceptions observed. LVH was found developed in those with moderate and severe AS. No clear correlation was found between diastolic dysfunction and the severity of AS. © 2022, Springer Nature Switzerland AG.
format Conference or Workshop Item
author Chuah, Shoon Hui
Thong, Wen Dee
Md Sari, Nor Ashikin
Tan, Li Kuo
Hasikin, Khairunnisa
Liew, Yih Miin
author_facet Chuah, Shoon Hui
Thong, Wen Dee
Md Sari, Nor Ashikin
Tan, Li Kuo
Hasikin, Khairunnisa
Liew, Yih Miin
author_sort Chuah, Shoon Hui
title Assessment of LV myocardial function in aortic stenosis using personalized 3D+ time cardiac MRI modelling
title_short Assessment of LV myocardial function in aortic stenosis using personalized 3D+ time cardiac MRI modelling
title_full Assessment of LV myocardial function in aortic stenosis using personalized 3D+ time cardiac MRI modelling
title_fullStr Assessment of LV myocardial function in aortic stenosis using personalized 3D+ time cardiac MRI modelling
title_full_unstemmed Assessment of LV myocardial function in aortic stenosis using personalized 3D+ time cardiac MRI modelling
title_sort assessment of lv myocardial function in aortic stenosis using personalized 3d+ time cardiac mri modelling
publisher Springer Science and Business Media Deutschland GmbH
publishDate 2022
url http://eprints.um.edu.my/43365/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85129333757&doi=10.1007%2f978-3-030-90724-2_46&partnerID=40&md5=104cf01b84b939438f4cc624e30c70db
_version_ 1825160591527903232
score 13.239859

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