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Bone-implant interface around titanium implants under different loading conditions: A histomorphometrical analysis in the Macaca fascicularis monkey

Background: Bone healing around endosseous dental implants is associated with peri-implant loading conditions. Therefore, the aim of this study was to evaluate histomorphometrically the bone response around unloaded, delayed, and immediately loaded implants with a progressive thread design that were...

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Main Authors: Romanos, G.E., Toh, C.G., Siar, C.H., Wicht, H., Yacoob, H., Nentwig, G.H.
Format: Article
Language:English
Published: 2003
Subjects:
RK Dentistry
Online Access:http://eprints.um.edu.my/4317/1/Bone-implant_interface_around_titanium_implants_under_different_loading_conditions_A_histomorphometrical_analysis_in_the_Macaca_fascicularis_monkey.pdf
http://eprints.um.edu.my/4317/
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spelling my.um.eprints.43172013-01-09T02:39:56Z http://eprints.um.edu.my/4317/ Bone-implant interface around titanium implants under different loading conditions: A histomorphometrical analysis in the Macaca fascicularis monkey Romanos, G.E. Toh, C.G. Siar, C.H. Wicht, H. Yacoob, H. Nentwig, G.H. RK Dentistry Background: Bone healing around endosseous dental implants is associated with peri-implant loading conditions. Therefore, the aim of this study was to evaluate histomorphometrically the bone response around unloaded, delayed, and immediately loaded implants with a progressive thread design that were placed in the posterior regions of the lower jaw in monkeys. Methods: Nine adult monkeys (Macaca fascicularis) were used in this study. After extraction of the second premolars and first and second molars in the mandible, the bone was allowed to heal for a period of 3 months. Forty-eight 8 mm long implants with a diameter of 3.5 mm were placed according to the following protocol. In two of the monkeys, six implants were placed and left to heal submerged for 3 months (group A). In seven monkeys, 21 implants were placed in one side of the mandible and loaded after 3 months of submerged healing (group B). The group B implants were loaded with temporary resin bridges at the same time as another 21 implants that were loaded immediately (group C) after placement in the contralateral side of the mandibles of the same monkeys. The occlusion of group B and C implants was checked for optimal relationship of the resin bridges that were replaced 1 month later with metal bridges and loaded for an additional 2 months. The group A animals were sacrificed after 3 months of submerged healing without loading; group B and C animals were sacrificed after 3 months of implant loading. Specimens were examined histologically and histomorphometrically. Results: All implants osseointegrated without presenting any gap in the metal-bone interface. Compact cortical bone was found in contact with the implant surfaces. Group A implants demonstrated in the interface cancellous bone with loose connective tissue. Group B and C in-plants showed a thick cortical plate with extensive bone trabeculae formation. There was a significant difference in bone-to-implant contact (BIC) between the various loading conditions. No significant difference (P<0.05) was found between groups B and C. There was an increased area of bone (BA) within the threads as well as around the apices of group B and C implants. Conclusions: Implant loading might have stimulated increased bone formation and thus may be a key factor in influencing positive osseointegration. In addition, immediately loaded implants may osseointegrate in a similar manner as delayed loaded implants. 2003 Article PeerReviewed application/pdf en http://eprints.um.edu.my/4317/1/Bone-implant_interface_around_titanium_implants_under_different_loading_conditions_A_histomorphometrical_analysis_in_the_Macaca_fascicularis_monkey.pdf Romanos, G.E. and Toh, C.G. and Siar, C.H. and Wicht, H. and Yacoob, H. and Nentwig, G.H. (2003) Bone-implant interface around titanium implants under different loading conditions: A histomorphometrical analysis in the Macaca fascicularis monkey. Journal of Periodontology, 74 (10). pp. 1483-1490. ISSN 0022-3492 10.1902/jop.2003.74.10.1483
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic RK Dentistry
spellingShingle RK Dentistry
Romanos, G.E.
Toh, C.G.
Siar, C.H.
Wicht, H.
Yacoob, H.
Nentwig, G.H.
Bone-implant interface around titanium implants under different loading conditions: A histomorphometrical analysis in the Macaca fascicularis monkey
description Background: Bone healing around endosseous dental implants is associated with peri-implant loading conditions. Therefore, the aim of this study was to evaluate histomorphometrically the bone response around unloaded, delayed, and immediately loaded implants with a progressive thread design that were placed in the posterior regions of the lower jaw in monkeys. Methods: Nine adult monkeys (Macaca fascicularis) were used in this study. After extraction of the second premolars and first and second molars in the mandible, the bone was allowed to heal for a period of 3 months. Forty-eight 8 mm long implants with a diameter of 3.5 mm were placed according to the following protocol. In two of the monkeys, six implants were placed and left to heal submerged for 3 months (group A). In seven monkeys, 21 implants were placed in one side of the mandible and loaded after 3 months of submerged healing (group B). The group B implants were loaded with temporary resin bridges at the same time as another 21 implants that were loaded immediately (group C) after placement in the contralateral side of the mandibles of the same monkeys. The occlusion of group B and C implants was checked for optimal relationship of the resin bridges that were replaced 1 month later with metal bridges and loaded for an additional 2 months. The group A animals were sacrificed after 3 months of submerged healing without loading; group B and C animals were sacrificed after 3 months of implant loading. Specimens were examined histologically and histomorphometrically. Results: All implants osseointegrated without presenting any gap in the metal-bone interface. Compact cortical bone was found in contact with the implant surfaces. Group A implants demonstrated in the interface cancellous bone with loose connective tissue. Group B and C in-plants showed a thick cortical plate with extensive bone trabeculae formation. There was a significant difference in bone-to-implant contact (BIC) between the various loading conditions. No significant difference (P<0.05) was found between groups B and C. There was an increased area of bone (BA) within the threads as well as around the apices of group B and C implants. Conclusions: Implant loading might have stimulated increased bone formation and thus may be a key factor in influencing positive osseointegration. In addition, immediately loaded implants may osseointegrate in a similar manner as delayed loaded implants.
format Article
author Romanos, G.E.
Toh, C.G.
Siar, C.H.
Wicht, H.
Yacoob, H.
Nentwig, G.H.
author_facet Romanos, G.E.
Toh, C.G.
Siar, C.H.
Wicht, H.
Yacoob, H.
Nentwig, G.H.
author_sort Romanos, G.E.
title Bone-implant interface around titanium implants under different loading conditions: A histomorphometrical analysis in the Macaca fascicularis monkey
title_short Bone-implant interface around titanium implants under different loading conditions: A histomorphometrical analysis in the Macaca fascicularis monkey
title_full Bone-implant interface around titanium implants under different loading conditions: A histomorphometrical analysis in the Macaca fascicularis monkey
title_fullStr Bone-implant interface around titanium implants under different loading conditions: A histomorphometrical analysis in the Macaca fascicularis monkey
title_full_unstemmed Bone-implant interface around titanium implants under different loading conditions: A histomorphometrical analysis in the Macaca fascicularis monkey
title_sort bone-implant interface around titanium implants under different loading conditions: a histomorphometrical analysis in the macaca fascicularis monkey
publishDate 2003
url http://eprints.um.edu.my/4317/1/Bone-implant_interface_around_titanium_implants_under_different_loading_conditions_A_histomorphometrical_analysis_in_the_Macaca_fascicularis_monkey.pdf
http://eprints.um.edu.my/4317/
_version_ 1643687306119348224
score 13.211869

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