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beta-Glucan-Rich extract of Gray Oyster Mushroom, Pleurotus pulmonarius, improves object recognition memory and Hippocampus Morphology in mice fed a high-fat diet

Obesity may cause behavioral alterations, while maternal obesity can contribute to metabolic disorders in subsequent generations. The effect of beta-glucan-rich Pleurotus pulmonarius (beta gPp) was investigated on mouse neurobehavior and hippocampus and its offspring's hippocampus development....

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Main Authors: Tarmizi, Nor Athirah Kamaliah Ahmad, Kushairi, Naufal, Phan, Chia Wei, Sabaratnam, Vikineswary, Kuppusamy Naidu, Murali, David, Pamela
Format: Article
Published: Mary Ann Liebert, Inc 2022
Subjects:
QD Chemistry
RA Public aspects of medicine
Online Access:http://eprints.um.edu.my/43063/
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spelling my.um.eprints.430632023-09-06T03:39:40Z http://eprints.um.edu.my/43063/ beta-Glucan-Rich extract of Gray Oyster Mushroom, Pleurotus pulmonarius, improves object recognition memory and Hippocampus Morphology in mice fed a high-fat diet Tarmizi, Nor Athirah Kamaliah Ahmad Kushairi, Naufal Phan, Chia Wei Sabaratnam, Vikineswary Kuppusamy Naidu, Murali David, Pamela QD Chemistry RA Public aspects of medicine Obesity may cause behavioral alterations, while maternal obesity can contribute to metabolic disorders in subsequent generations. The effect of beta-glucan-rich Pleurotus pulmonarius (beta gPp) was investigated on mouse neurobehavior and hippocampus and its offspring's hippocampus development. Female ICR mice were fed with normal diet (ND), ND with beta gPp, high-fat diet (HFD), or HFD with beta gPp for 3 months followed by behavioral test and mating. Immunohistochemistry for the expression of neuronal nuclear protein (NeuN) and ionized calcium binding adaptor molecule-1 (Iba-1) in the hippocampus was carried out. beta gPp significantly enhanced short-term object recognition memory in HFD-fed mice. beta gPp also ameliorated the histological alterations and neuronal loss and increased Iba-1-positive microglia in the hippocampus regions of HFD-fed mice and their male offspring. These findings demonstrated that beta gPp supplementation attenuated the effects of HFD on object recognition memory and the alterations on the hippocampal regions of maternal mice and their male offspring. Mary Ann Liebert, Inc 2022-03-01 Article PeerReviewed Tarmizi, Nor Athirah Kamaliah Ahmad and Kushairi, Naufal and Phan, Chia Wei and Sabaratnam, Vikineswary and Kuppusamy Naidu, Murali and David, Pamela (2022) beta-Glucan-Rich extract of Gray Oyster Mushroom, Pleurotus pulmonarius, improves object recognition memory and Hippocampus Morphology in mice fed a high-fat diet. Journal of Medicinal Food, 25 (3). pp. 230-238. ISSN 1096-620X, DOI https://doi.org/10.1089/jmf.2021.K.0121 <https://doi.org/10.1089/jmf.2021.K.0121>. 10.1089/jmf.2021.K.0121
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QD Chemistry
RA Public aspects of medicine
spellingShingle QD Chemistry
RA Public aspects of medicine
Tarmizi, Nor Athirah Kamaliah Ahmad
Kushairi, Naufal
Phan, Chia Wei
Sabaratnam, Vikineswary
Kuppusamy Naidu, Murali
David, Pamela
beta-Glucan-Rich extract of Gray Oyster Mushroom, Pleurotus pulmonarius, improves object recognition memory and Hippocampus Morphology in mice fed a high-fat diet
description Obesity may cause behavioral alterations, while maternal obesity can contribute to metabolic disorders in subsequent generations. The effect of beta-glucan-rich Pleurotus pulmonarius (beta gPp) was investigated on mouse neurobehavior and hippocampus and its offspring's hippocampus development. Female ICR mice were fed with normal diet (ND), ND with beta gPp, high-fat diet (HFD), or HFD with beta gPp for 3 months followed by behavioral test and mating. Immunohistochemistry for the expression of neuronal nuclear protein (NeuN) and ionized calcium binding adaptor molecule-1 (Iba-1) in the hippocampus was carried out. beta gPp significantly enhanced short-term object recognition memory in HFD-fed mice. beta gPp also ameliorated the histological alterations and neuronal loss and increased Iba-1-positive microglia in the hippocampus regions of HFD-fed mice and their male offspring. These findings demonstrated that beta gPp supplementation attenuated the effects of HFD on object recognition memory and the alterations on the hippocampal regions of maternal mice and their male offspring.
format Article
author Tarmizi, Nor Athirah Kamaliah Ahmad
Kushairi, Naufal
Phan, Chia Wei
Sabaratnam, Vikineswary
Kuppusamy Naidu, Murali
David, Pamela
author_facet Tarmizi, Nor Athirah Kamaliah Ahmad
Kushairi, Naufal
Phan, Chia Wei
Sabaratnam, Vikineswary
Kuppusamy Naidu, Murali
David, Pamela
author_sort Tarmizi, Nor Athirah Kamaliah Ahmad
title beta-Glucan-Rich extract of Gray Oyster Mushroom, Pleurotus pulmonarius, improves object recognition memory and Hippocampus Morphology in mice fed a high-fat diet
title_short beta-Glucan-Rich extract of Gray Oyster Mushroom, Pleurotus pulmonarius, improves object recognition memory and Hippocampus Morphology in mice fed a high-fat diet
title_full beta-Glucan-Rich extract of Gray Oyster Mushroom, Pleurotus pulmonarius, improves object recognition memory and Hippocampus Morphology in mice fed a high-fat diet
title_fullStr beta-Glucan-Rich extract of Gray Oyster Mushroom, Pleurotus pulmonarius, improves object recognition memory and Hippocampus Morphology in mice fed a high-fat diet
title_full_unstemmed beta-Glucan-Rich extract of Gray Oyster Mushroom, Pleurotus pulmonarius, improves object recognition memory and Hippocampus Morphology in mice fed a high-fat diet
title_sort beta-glucan-rich extract of gray oyster mushroom, pleurotus pulmonarius, improves object recognition memory and hippocampus morphology in mice fed a high-fat diet
publisher Mary Ann Liebert, Inc
publishDate 2022
url http://eprints.um.edu.my/43063/
_version_ 1778161691396145152
score 13.211869

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