Staff View: Mechanotransduction in Mesenchymal Stem Cells (MSCs) differentiation: A review

Mechanotransduction in Mesenchymal Stem Cells (MSCs) differentiation: A review

Mechanotransduction is the process by which physical force is converted into a biochemical signal that is used in development and physiology; meanwhile, it is intended for the ability of cells to sense and respond to mechanical forces by activating intracellular signals transduction pathways and the...

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Main Authors:	Raman, Narmadaa, Imran, Siti A. M., Ahmad Amin Noordin, Khairul Bariah, Wan Kamarul Zaman, Wan Safwani, Nordin, Fazlina
Format:	Article
Published:	MDPI 2022
Subjects:	QD Chemistry QH301 Biology
Online Access:	http://eprints.um.edu.my/42850/
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spelling	my.um.eprints.428502023-10-07T02:01:55Z http://eprints.um.edu.my/42850/ Mechanotransduction in Mesenchymal Stem Cells (MSCs) differentiation: A review Raman, Narmadaa Imran, Siti A. M. Ahmad Amin Noordin, Khairul Bariah Wan Kamarul Zaman, Wan Safwani Nordin, Fazlina QD Chemistry QH301 Biology Mechanotransduction is the process by which physical force is converted into a biochemical signal that is used in development and physiology; meanwhile, it is intended for the ability of cells to sense and respond to mechanical forces by activating intracellular signals transduction pathways and the relative phenotypic adaptation. It encompasses the role of mechanical stimuli for developmental, morphological characteristics, and biological processes in different organs; the response of cells to mechanically induced force is now also emerging as a major determinant of disease. Due to fluid shear stress caused by blood flowing tangentially across the lumen surface, cells of the cardiovascular system are typically exposed to a variety of mechanotransduction. In the body, tissues are continuously exposed to physical forces ranging from compression to strain, which is caused by fluid pressure and compressive forces. Only lately, though, has the importance of how forces shape stem cell differentiation into lineage-committed cells and how mechanical forces can cause or exacerbate disease besides organizing cells into tissues been acknowledged. Mesenchymal stem cells (MSCs) are potent mediators of cardiac repair which can secret a large array of soluble factors that have been shown to play a huge role in tissue repair. Differentiation of MSCs is required to regulate mechanical factors such as fluid shear stress, mechanical strain, and the rigidity of the extracellular matrix through various signaling pathways for their use in regenerative medicine. In the present review, we highlighted mechanical influences on the differentiation of MSCs and the general factors involved in MSCs differentiation. The purpose of this study is to demonstrate the progress that has been achieved in understanding how MSCs perceive and react to their mechanical environment, as well as to highlight areas where more research has been performed in previous studies to fill in the gaps. MDPI 2022-05 Article PeerReviewed Raman, Narmadaa and Imran, Siti A. M. and Ahmad Amin Noordin, Khairul Bariah and Wan Kamarul Zaman, Wan Safwani and Nordin, Fazlina (2022) Mechanotransduction in Mesenchymal Stem Cells (MSCs) differentiation: A review. International Journal of Molecular Sciences, 23 (9). ISSN 1422-0067, DOI https://doi.org/10.3390/ijms23094580 <https://doi.org/10.3390/ijms23094580>. 10.3390/ijms23094580
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	QD Chemistry QH301 Biology
spellingShingle	QD Chemistry QH301 Biology Raman, Narmadaa Imran, Siti A. M. Ahmad Amin Noordin, Khairul Bariah Wan Kamarul Zaman, Wan Safwani Nordin, Fazlina Mechanotransduction in Mesenchymal Stem Cells (MSCs) differentiation: A review
description	Mechanotransduction is the process by which physical force is converted into a biochemical signal that is used in development and physiology; meanwhile, it is intended for the ability of cells to sense and respond to mechanical forces by activating intracellular signals transduction pathways and the relative phenotypic adaptation. It encompasses the role of mechanical stimuli for developmental, morphological characteristics, and biological processes in different organs; the response of cells to mechanically induced force is now also emerging as a major determinant of disease. Due to fluid shear stress caused by blood flowing tangentially across the lumen surface, cells of the cardiovascular system are typically exposed to a variety of mechanotransduction. In the body, tissues are continuously exposed to physical forces ranging from compression to strain, which is caused by fluid pressure and compressive forces. Only lately, though, has the importance of how forces shape stem cell differentiation into lineage-committed cells and how mechanical forces can cause or exacerbate disease besides organizing cells into tissues been acknowledged. Mesenchymal stem cells (MSCs) are potent mediators of cardiac repair which can secret a large array of soluble factors that have been shown to play a huge role in tissue repair. Differentiation of MSCs is required to regulate mechanical factors such as fluid shear stress, mechanical strain, and the rigidity of the extracellular matrix through various signaling pathways for their use in regenerative medicine. In the present review, we highlighted mechanical influences on the differentiation of MSCs and the general factors involved in MSCs differentiation. The purpose of this study is to demonstrate the progress that has been achieved in understanding how MSCs perceive and react to their mechanical environment, as well as to highlight areas where more research has been performed in previous studies to fill in the gaps.
format	Article
author	Raman, Narmadaa Imran, Siti A. M. Ahmad Amin Noordin, Khairul Bariah Wan Kamarul Zaman, Wan Safwani Nordin, Fazlina
author_facet	Raman, Narmadaa Imran, Siti A. M. Ahmad Amin Noordin, Khairul Bariah Wan Kamarul Zaman, Wan Safwani Nordin, Fazlina
author_sort	Raman, Narmadaa
title	Mechanotransduction in Mesenchymal Stem Cells (MSCs) differentiation: A review
title_short	Mechanotransduction in Mesenchymal Stem Cells (MSCs) differentiation: A review
title_full	Mechanotransduction in Mesenchymal Stem Cells (MSCs) differentiation: A review
title_fullStr	Mechanotransduction in Mesenchymal Stem Cells (MSCs) differentiation: A review
title_full_unstemmed	Mechanotransduction in Mesenchymal Stem Cells (MSCs) differentiation: A review
title_sort	mechanotransduction in mesenchymal stem cells (mscs) differentiation: a review
publisher	MDPI
publishDate	2022
url	http://eprints.um.edu.my/42850/
_version_	1781704653445005312
score	13.211869

Mechanotransduction in Mesenchymal Stem Cells (MSCs) differentiation: A review

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