Prevalence and risk factors for endocrine disorders in childhood brain tumors from a single tertiary center in Malaysia

Patients with childhood brain tumors are at risk of endocrine disorders. The prevalence of endocrine disorders varies across the world but is unknown in Malaysia. This study's objectives were to determine the prevalence of endocrine disorders among children with brain tumors in Malaysia and to...

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Main Authors: Ng, Yean Joo, Jalaludin, Muhammad Yazid, Foo, Jen Chun, Qaddoumi, Ibrahim, Rajagopal, Revathi
Format: Article
Published: Lippincott Williams & Wilkins 2022
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Online Access:http://eprints.um.edu.my/42847/
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spelling my.um.eprints.428472023-10-08T12:52:30Z http://eprints.um.edu.my/42847/ Prevalence and risk factors for endocrine disorders in childhood brain tumors from a single tertiary center in Malaysia Ng, Yean Joo Jalaludin, Muhammad Yazid Foo, Jen Chun Qaddoumi, Ibrahim Rajagopal, Revathi R Medicine RJ Pediatrics Patients with childhood brain tumors are at risk of endocrine disorders. The prevalence of endocrine disorders varies across the world but is unknown in Malaysia. This study's objectives were to determine the prevalence of endocrine disorders among children with brain tumors in Malaysia and to identify endocrinopathy-associated risk factors. We retrospectively reviewed the clinical data of pediatric patients with brain tumors diagnosed and treated at the University Malaya Medical Center from 1 January 2001 to 31 December 2015, with a follow-up period until the age of 18 years old or at least 3 years from the initial diagnosis. A total of 106 patients were included; 71 patients (66%) were screened for endocrine disorders, and 61% of these had endocrine disorders at a median follow-up of 4 years. Hypothyroidism, short stature, and adrenocortical insufficiency were present in one-third of the patients, followed by central diabetes insipidus (21%), growth hormone deficiency (10%), delayed puberty (9%), and precocious puberty (4%). Radiation therapy and surgical intervention were risk factors for endocrine disorders, but hydrocephalus, supratentorial tumors, and malignant tumors were not. Most endocrinopathies developed within the first 2 years of brain tumor diagnosis. Therefore, standard endocrine-monitoring guidelines aiming for early diagnosis and therapy are essential. Lippincott Williams & Wilkins 2022-05 Article PeerReviewed Ng, Yean Joo and Jalaludin, Muhammad Yazid and Foo, Jen Chun and Qaddoumi, Ibrahim and Rajagopal, Revathi (2022) Prevalence and risk factors for endocrine disorders in childhood brain tumors from a single tertiary center in Malaysia. Journal Of Pediatric Hematology Oncology, 44 (4). pp. 159-166. ISSN 1077-4114, DOI https://doi.org/10.1097/MPH.0000000000002447 <https://doi.org/10.1097/MPH.0000000000002447>. 10.1097/MPH.0000000000002447
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
RJ Pediatrics
spellingShingle R Medicine
RJ Pediatrics
Ng, Yean Joo
Jalaludin, Muhammad Yazid
Foo, Jen Chun
Qaddoumi, Ibrahim
Rajagopal, Revathi
Prevalence and risk factors for endocrine disorders in childhood brain tumors from a single tertiary center in Malaysia
description Patients with childhood brain tumors are at risk of endocrine disorders. The prevalence of endocrine disorders varies across the world but is unknown in Malaysia. This study's objectives were to determine the prevalence of endocrine disorders among children with brain tumors in Malaysia and to identify endocrinopathy-associated risk factors. We retrospectively reviewed the clinical data of pediatric patients with brain tumors diagnosed and treated at the University Malaya Medical Center from 1 January 2001 to 31 December 2015, with a follow-up period until the age of 18 years old or at least 3 years from the initial diagnosis. A total of 106 patients were included; 71 patients (66%) were screened for endocrine disorders, and 61% of these had endocrine disorders at a median follow-up of 4 years. Hypothyroidism, short stature, and adrenocortical insufficiency were present in one-third of the patients, followed by central diabetes insipidus (21%), growth hormone deficiency (10%), delayed puberty (9%), and precocious puberty (4%). Radiation therapy and surgical intervention were risk factors for endocrine disorders, but hydrocephalus, supratentorial tumors, and malignant tumors were not. Most endocrinopathies developed within the first 2 years of brain tumor diagnosis. Therefore, standard endocrine-monitoring guidelines aiming for early diagnosis and therapy are essential.
format Article
author Ng, Yean Joo
Jalaludin, Muhammad Yazid
Foo, Jen Chun
Qaddoumi, Ibrahim
Rajagopal, Revathi
author_facet Ng, Yean Joo
Jalaludin, Muhammad Yazid
Foo, Jen Chun
Qaddoumi, Ibrahim
Rajagopal, Revathi
author_sort Ng, Yean Joo
title Prevalence and risk factors for endocrine disorders in childhood brain tumors from a single tertiary center in Malaysia
title_short Prevalence and risk factors for endocrine disorders in childhood brain tumors from a single tertiary center in Malaysia
title_full Prevalence and risk factors for endocrine disorders in childhood brain tumors from a single tertiary center in Malaysia
title_fullStr Prevalence and risk factors for endocrine disorders in childhood brain tumors from a single tertiary center in Malaysia
title_full_unstemmed Prevalence and risk factors for endocrine disorders in childhood brain tumors from a single tertiary center in Malaysia
title_sort prevalence and risk factors for endocrine disorders in childhood brain tumors from a single tertiary center in malaysia
publisher Lippincott Williams & Wilkins
publishDate 2022
url http://eprints.um.edu.my/42847/
_version_ 1781704653015089152
score 13.211869