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Green and solid-phase synthesis of new dihydro-1,2,4]triazolo1,5-a]pyrimidine scaffolds by using poly-melamine-formaldehyde as a nitrogen-rich porous organocatalyst

This work presents a new catalytic application of porous poly-melamine-formaldehyde (mPMF) for the efficient synthesis of new dihydro-1,2,4]triazolo1,5-a]pyrimidines. According to the principals of green chemistry, the reaction was performed by the planetary ball milling process at ambient and neat...

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Main Authors: Khaligh, Nader Ghaffari, Mihankhah, Taraneh
Format: Article
Published: Taylor & Francis 2022
Subjects:
H Social Sciences (General)
Online Access:http://eprints.um.edu.my/42487/
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spelling my.um.eprints.424872023-10-10T06:06:01Z http://eprints.um.edu.my/42487/ Green and solid-phase synthesis of new dihydro-1,2,4]triazolo1,5-a]pyrimidine scaffolds by using poly-melamine-formaldehyde as a nitrogen-rich porous organocatalyst Khaligh, Nader Ghaffari Mihankhah, Taraneh H Social Sciences (General) This work presents a new catalytic application of porous poly-melamine-formaldehyde (mPMF) for the efficient synthesis of new dihydro-1,2,4]triazolo1,5-a]pyrimidines. According to the principals of green chemistry, the reaction was performed by the planetary ball milling process at ambient and neat conditions. The heterogeneous catalyst could be reused up to five runs with no reducing of catalytic efficiency. A variety of substituted dihydro-1,2,4]triazolo1,5-a]pyrimidines were obtained in good to excellent yields under eco-friendly conditions. This work revealed that bifunctional porous organic polymers (POPs) containing base sites and acceptor-donner hydrogen bonding groups, as well as high porosity could play a vital role in the promotion of the one-pot multicomponent reactions in the solid phase. The main merits of the current methodology include short reaction time, wide substrate-scope, and use of a metal-free heterogeneous organocatalyst, simple work-up process. Taylor & Francis 2022-04 Article PeerReviewed Khaligh, Nader Ghaffari and Mihankhah, Taraneh (2022) Green and solid-phase synthesis of new dihydro-1,2,4]triazolo1,5-a]pyrimidine scaffolds by using poly-melamine-formaldehyde as a nitrogen-rich porous organocatalyst. Polycyclic Aromatic Compounds, 42 (3). pp. 942-950. ISSN 1040-6638, DOI https://doi.org/10.1080/10406638.2020.1756357 <https://doi.org/10.1080/10406638.2020.1756357>. 10.1080/10406638.2020.1756357
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic H Social Sciences (General)
spellingShingle H Social Sciences (General)
Khaligh, Nader Ghaffari
Mihankhah, Taraneh
Green and solid-phase synthesis of new dihydro-1,2,4]triazolo1,5-a]pyrimidine scaffolds by using poly-melamine-formaldehyde as a nitrogen-rich porous organocatalyst
description This work presents a new catalytic application of porous poly-melamine-formaldehyde (mPMF) for the efficient synthesis of new dihydro-1,2,4]triazolo1,5-a]pyrimidines. According to the principals of green chemistry, the reaction was performed by the planetary ball milling process at ambient and neat conditions. The heterogeneous catalyst could be reused up to five runs with no reducing of catalytic efficiency. A variety of substituted dihydro-1,2,4]triazolo1,5-a]pyrimidines were obtained in good to excellent yields under eco-friendly conditions. This work revealed that bifunctional porous organic polymers (POPs) containing base sites and acceptor-donner hydrogen bonding groups, as well as high porosity could play a vital role in the promotion of the one-pot multicomponent reactions in the solid phase. The main merits of the current methodology include short reaction time, wide substrate-scope, and use of a metal-free heterogeneous organocatalyst, simple work-up process.
format Article
author Khaligh, Nader Ghaffari
Mihankhah, Taraneh
author_facet Khaligh, Nader Ghaffari
Mihankhah, Taraneh
author_sort Khaligh, Nader Ghaffari
title Green and solid-phase synthesis of new dihydro-1,2,4]triazolo1,5-a]pyrimidine scaffolds by using poly-melamine-formaldehyde as a nitrogen-rich porous organocatalyst
title_short Green and solid-phase synthesis of new dihydro-1,2,4]triazolo1,5-a]pyrimidine scaffolds by using poly-melamine-formaldehyde as a nitrogen-rich porous organocatalyst
title_full Green and solid-phase synthesis of new dihydro-1,2,4]triazolo1,5-a]pyrimidine scaffolds by using poly-melamine-formaldehyde as a nitrogen-rich porous organocatalyst
title_fullStr Green and solid-phase synthesis of new dihydro-1,2,4]triazolo1,5-a]pyrimidine scaffolds by using poly-melamine-formaldehyde as a nitrogen-rich porous organocatalyst
title_full_unstemmed Green and solid-phase synthesis of new dihydro-1,2,4]triazolo1,5-a]pyrimidine scaffolds by using poly-melamine-formaldehyde as a nitrogen-rich porous organocatalyst
title_sort green and solid-phase synthesis of new dihydro-1,2,4]triazolo1,5-a]pyrimidine scaffolds by using poly-melamine-formaldehyde as a nitrogen-rich porous organocatalyst
publisher Taylor & Francis
publishDate 2022
url http://eprints.um.edu.my/42487/
_version_ 1781704650590781440
score 13.211869

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