Staff View: A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications

A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications

Commercially pure titanium and titanium alloys have been among the most commonly used materials for biomedical applications since the 1950s. Due to the excellent mechanical tribological properties, corrosion resistance, biocompatibility, and antibacterial properties of titanium, it is getting much a...

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Main Authors:	Sarraf, Masoud, Rezvani Ghomi, Erfan, Alipour, Saeid, Ramakrishna, Seeram, Sukiman, Nazatul Liana
Format:	Article
Published:	SPRINGER HEIDELBERG 2022
Subjects:	TJ Mechanical engineering and machinery
Online Access:	http://eprints.um.edu.my/42420/
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spelling	my.um.eprints.424202023-10-09T08:13:03Z http://eprints.um.edu.my/42420/ A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications Sarraf, Masoud Rezvani Ghomi, Erfan Alipour, Saeid Ramakrishna, Seeram Sukiman, Nazatul Liana TJ Mechanical engineering and machinery Commercially pure titanium and titanium alloys have been among the most commonly used materials for biomedical applications since the 1950s. Due to the excellent mechanical tribological properties, corrosion resistance, biocompatibility, and antibacterial properties of titanium, it is getting much attention as a biomaterial for implants. Furthermore, titanium promotes osseointegration without any additional adhesives by physically bonding with the living bone at the implant site. These properties are crucial for producing high-strength metallic alloys for biomedical applications. Titanium alloys are manufactured into the three types of alpha, beta, and alpha + beta. The scientific and clinical understanding of titanium and its potential applications, especially in the biomedical field, are still in the early stages. This review aims to establish a credible platform for the current and future roles of titanium in biomedicine. We first explore the developmental history of titanium. Then, we review the recent advancement of the utility of titanium in diverse biomedical areas, its functional properties, mechanisms of biocompatibility, host tissue responses, and various relevant antimicrobial strategies. Future research will be directed toward advanced manufacturing technologies, such as powder-based additive manufacturing, electron beam melting and laser melting deposition, as well as analyzing the effects of alloying elements on the biocompatibility, corrosion resistance, and mechanical properties of titanium. Moreover, the role of titania nanotubes in regenerative medicine and nanomedicine applications, such as localized drug delivery system, immunomodulatory agents, antibacterial agents, and hemocompatibility, is investigated, and the paper concludes with the future outlook of titanium alloys as biomaterials. SPRINGER HEIDELBERG 2022-04 Article PeerReviewed Sarraf, Masoud and Rezvani Ghomi, Erfan and Alipour, Saeid and Ramakrishna, Seeram and Sukiman, Nazatul Liana (2022) A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications. Bio-Design and Manufacturing, 5 (2). pp. 371-395. ISSN 2096-5524, DOI https://doi.org/10.1007/s42242-021-00170-3 <https://doi.org/10.1007/s42242-021-00170-3>. 10.1007/s42242-021-00170-3
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	TJ Mechanical engineering and machinery
spellingShingle	TJ Mechanical engineering and machinery Sarraf, Masoud Rezvani Ghomi, Erfan Alipour, Saeid Ramakrishna, Seeram Sukiman, Nazatul Liana A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications
description	Commercially pure titanium and titanium alloys have been among the most commonly used materials for biomedical applications since the 1950s. Due to the excellent mechanical tribological properties, corrosion resistance, biocompatibility, and antibacterial properties of titanium, it is getting much attention as a biomaterial for implants. Furthermore, titanium promotes osseointegration without any additional adhesives by physically bonding with the living bone at the implant site. These properties are crucial for producing high-strength metallic alloys for biomedical applications. Titanium alloys are manufactured into the three types of alpha, beta, and alpha + beta. The scientific and clinical understanding of titanium and its potential applications, especially in the biomedical field, are still in the early stages. This review aims to establish a credible platform for the current and future roles of titanium in biomedicine. We first explore the developmental history of titanium. Then, we review the recent advancement of the utility of titanium in diverse biomedical areas, its functional properties, mechanisms of biocompatibility, host tissue responses, and various relevant antimicrobial strategies. Future research will be directed toward advanced manufacturing technologies, such as powder-based additive manufacturing, electron beam melting and laser melting deposition, as well as analyzing the effects of alloying elements on the biocompatibility, corrosion resistance, and mechanical properties of titanium. Moreover, the role of titania nanotubes in regenerative medicine and nanomedicine applications, such as localized drug delivery system, immunomodulatory agents, antibacterial agents, and hemocompatibility, is investigated, and the paper concludes with the future outlook of titanium alloys as biomaterials.
format	Article
author	Sarraf, Masoud Rezvani Ghomi, Erfan Alipour, Saeid Ramakrishna, Seeram Sukiman, Nazatul Liana
author_facet	Sarraf, Masoud Rezvani Ghomi, Erfan Alipour, Saeid Ramakrishna, Seeram Sukiman, Nazatul Liana
author_sort	Sarraf, Masoud
title	A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications
title_short	A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications
title_full	A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications
title_fullStr	A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications
title_full_unstemmed	A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications
title_sort	state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications
publisher	SPRINGER HEIDELBERG
publishDate	2022
url	http://eprints.um.edu.my/42420/
_version_	1781704641302495232
score	13.211869

A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications

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