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Antimalarial activity of methanolic leaf extract of piper betle L

The need for new compounds active against malaria parasites is made more urgent by the rapid spread of drug-resistance to available antimalarial drugs. The crude methanol extract of Piper betle leaves (50-400 mg/kg) was investigated for its antimalarial activity against Plasmodium berghei (NK65) dur...

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Main Authors: Al-Adhroey, A.H., Nor, Z.M., Al-Mekhlafi, H.M., Amran, A.A., Mahmud, R.
Format: Article
Language:English
Published: 2011
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/4229/1/Al-Adhroey-2011-Antimalarial_Activit.pdf
http://eprints.um.edu.my/4229/
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spelling my.um.eprints.42292013-01-08T01:39:08Z http://eprints.um.edu.my/4229/ Antimalarial activity of methanolic leaf extract of piper betle L Al-Adhroey, A.H. Nor, Z.M. Al-Mekhlafi, H.M. Amran, A.A. Mahmud, R. R Medicine The need for new compounds active against malaria parasites is made more urgent by the rapid spread of drug-resistance to available antimalarial drugs. The crude methanol extract of Piper betle leaves (50-400 mg/kg) was investigated for its antimalarial activity against Plasmodium berghei (NK65) during early and established infections. The phytochemical and antioxidant potentials of the crude extract were evaluated to elucidate the possibilities of its antimalarial effects. The safety of the extract was also investigated in ICR mice of both sexes by the acute oral toxicity limit test. The leaf extract demonstrated significant (P < 0.05) schizonticidal activity in all three antimalarial evaluation models. Phytochemical screening showed that the leaf extract contains some vital antiplasmodial chemical constituents. The extract also exhibited a potent ability to scavenge the free radicals. The results of acute toxicity showed that the methanol extract of Piper betle leaves is toxicologically safe by oral administration. The results suggest that the Malaysian folklorical medicinal application of the extract of Piper betle leaf has a pharmacological basis. 2011 Article PeerReviewed application/pdf en http://eprints.um.edu.my/4229/1/Al-Adhroey-2011-Antimalarial_Activit.pdf Al-Adhroey, A.H. and Nor, Z.M. and Al-Mekhlafi, H.M. and Amran, A.A. and Mahmud, R. (2011) Antimalarial activity of methanolic leaf extract of piper betle L. Molecules, 16 (1). pp. 107-118. ISSN 1420-3049
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic R Medicine
spellingShingle R Medicine
Al-Adhroey, A.H.
Nor, Z.M.
Al-Mekhlafi, H.M.
Amran, A.A.
Mahmud, R.
Antimalarial activity of methanolic leaf extract of piper betle L
description The need for new compounds active against malaria parasites is made more urgent by the rapid spread of drug-resistance to available antimalarial drugs. The crude methanol extract of Piper betle leaves (50-400 mg/kg) was investigated for its antimalarial activity against Plasmodium berghei (NK65) during early and established infections. The phytochemical and antioxidant potentials of the crude extract were evaluated to elucidate the possibilities of its antimalarial effects. The safety of the extract was also investigated in ICR mice of both sexes by the acute oral toxicity limit test. The leaf extract demonstrated significant (P < 0.05) schizonticidal activity in all three antimalarial evaluation models. Phytochemical screening showed that the leaf extract contains some vital antiplasmodial chemical constituents. The extract also exhibited a potent ability to scavenge the free radicals. The results of acute toxicity showed that the methanol extract of Piper betle leaves is toxicologically safe by oral administration. The results suggest that the Malaysian folklorical medicinal application of the extract of Piper betle leaf has a pharmacological basis.
format Article
author Al-Adhroey, A.H.
Nor, Z.M.
Al-Mekhlafi, H.M.
Amran, A.A.
Mahmud, R.
author_facet Al-Adhroey, A.H.
Nor, Z.M.
Al-Mekhlafi, H.M.
Amran, A.A.
Mahmud, R.
author_sort Al-Adhroey, A.H.
title Antimalarial activity of methanolic leaf extract of piper betle L
title_short Antimalarial activity of methanolic leaf extract of piper betle L
title_full Antimalarial activity of methanolic leaf extract of piper betle L
title_fullStr Antimalarial activity of methanolic leaf extract of piper betle L
title_full_unstemmed Antimalarial activity of methanolic leaf extract of piper betle L
title_sort antimalarial activity of methanolic leaf extract of piper betle l
publishDate 2011
url http://eprints.um.edu.my/4229/1/Al-Adhroey-2011-Antimalarial_Activit.pdf
http://eprints.um.edu.my/4229/
_version_ 1643687291146731520
score 13.211869

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