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Chitosan and its derivatives as polymeric anti-viral therapeutics and potential anti-SARS-CoV-2 nanomedicine

The coronavirus pandemic, COVID-19 has a global impact on the lives and livelihoods of people. It is characterized by a widespread infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), where infected patients may develop serious medical complications or even face death. Deve...

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Main Authors: Tan, Rebecca Shu Ling, Hassandarvish, Pouya, Chee, Chin Fei, Chan, Lai Wah, Wong, Tin Wui
Format: Article
Published: Elsevier 2022
Subjects:
QD Chemistry
R Medicine (General)
Online Access:http://eprints.um.edu.my/42269/
https://doi.org/10.1016/j.carbpol.2022.119500
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spelling my.um.eprints.422692023-10-11T04:55:54Z http://eprints.um.edu.my/42269/ Chitosan and its derivatives as polymeric anti-viral therapeutics and potential anti-SARS-CoV-2 nanomedicine Tan, Rebecca Shu Ling Hassandarvish, Pouya Chee, Chin Fei Chan, Lai Wah Wong, Tin Wui QD Chemistry R Medicine (General) The coronavirus pandemic, COVID-19 has a global impact on the lives and livelihoods of people. It is characterized by a widespread infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), where infected patients may develop serious medical complications or even face death. Development of therapeutic is essential to reduce the morbidity and mortality of infected patients. Chitosan is a versatile biomaterial in nanomedicine and exhibits anti-microbial, anti-cancer and immunomodulatory properties. This review highlights the progress in chitosan design and application pertaining to the anti-viral effects of chitosan and chitosan derivatives (hydroxypropyl trimethylammonium, sulfate, carboxymethyl, bromine, sialylglycopolymer, peptide and phosphonium conjugates) as a function of molecular weight, degree of deacetylation, type of substituents and their degree and site of substitution. The physicochemical attributes of these polymeric therapeutics are identified against the possibility of processing them into nanomedicine which can confer a higher level of antiviral efficacy. The designs of chitosan for the purpose of targeting SARS-CoV-2, as well as the ever-evolving strains of viruses with a broad spectrum anti-viral activity to meet pandemic preparedness at the early stages of outbreak are discussed. Elsevier 2022-08-05 Article PeerReviewed Tan, Rebecca Shu Ling and Hassandarvish, Pouya and Chee, Chin Fei and Chan, Lai Wah and Wong, Tin Wui (2022) Chitosan and its derivatives as polymeric anti-viral therapeutics and potential anti-SARS-CoV-2 nanomedicine. Carbohydrate Polymers, 290. ISSN 0144-8617, DOI https://doi.org/10.1016/j.carbpol.2022.119500 <https://doi.org/10.1016/j.carbpol.2022.119500>. https://doi.org/10.1016/j.carbpol.2022.119500 10.1016/j.carbpol.2022.119500
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QD Chemistry
R Medicine (General)
spellingShingle QD Chemistry
R Medicine (General)
Tan, Rebecca Shu Ling
Hassandarvish, Pouya
Chee, Chin Fei
Chan, Lai Wah
Wong, Tin Wui
Chitosan and its derivatives as polymeric anti-viral therapeutics and potential anti-SARS-CoV-2 nanomedicine
description The coronavirus pandemic, COVID-19 has a global impact on the lives and livelihoods of people. It is characterized by a widespread infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), where infected patients may develop serious medical complications or even face death. Development of therapeutic is essential to reduce the morbidity and mortality of infected patients. Chitosan is a versatile biomaterial in nanomedicine and exhibits anti-microbial, anti-cancer and immunomodulatory properties. This review highlights the progress in chitosan design and application pertaining to the anti-viral effects of chitosan and chitosan derivatives (hydroxypropyl trimethylammonium, sulfate, carboxymethyl, bromine, sialylglycopolymer, peptide and phosphonium conjugates) as a function of molecular weight, degree of deacetylation, type of substituents and their degree and site of substitution. The physicochemical attributes of these polymeric therapeutics are identified against the possibility of processing them into nanomedicine which can confer a higher level of antiviral efficacy. The designs of chitosan for the purpose of targeting SARS-CoV-2, as well as the ever-evolving strains of viruses with a broad spectrum anti-viral activity to meet pandemic preparedness at the early stages of outbreak are discussed.
format Article
author Tan, Rebecca Shu Ling
Hassandarvish, Pouya
Chee, Chin Fei
Chan, Lai Wah
Wong, Tin Wui
author_facet Tan, Rebecca Shu Ling
Hassandarvish, Pouya
Chee, Chin Fei
Chan, Lai Wah
Wong, Tin Wui
author_sort Tan, Rebecca Shu Ling
title Chitosan and its derivatives as polymeric anti-viral therapeutics and potential anti-SARS-CoV-2 nanomedicine
title_short Chitosan and its derivatives as polymeric anti-viral therapeutics and potential anti-SARS-CoV-2 nanomedicine
title_full Chitosan and its derivatives as polymeric anti-viral therapeutics and potential anti-SARS-CoV-2 nanomedicine
title_fullStr Chitosan and its derivatives as polymeric anti-viral therapeutics and potential anti-SARS-CoV-2 nanomedicine
title_full_unstemmed Chitosan and its derivatives as polymeric anti-viral therapeutics and potential anti-SARS-CoV-2 nanomedicine
title_sort chitosan and its derivatives as polymeric anti-viral therapeutics and potential anti-sars-cov-2 nanomedicine
publisher Elsevier
publishDate 2022
url http://eprints.um.edu.my/42269/
https://doi.org/10.1016/j.carbpol.2022.119500
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score 13.211869

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