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Effect of carbonate content on the in vitro bioactivity of carbonated hydroxyapatite

The effect of carbonate content on the apatite-forming ability of carbonated hydroxyapatite (CHA) in simulated body fluid (SBF) has been investigated. Five different nanocrystalline B-type CHA with carbonate content ranged from 2.01 to 5.25 wt% were prepared, sintered, and assessed for their in vitr...

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Main Authors: Safarzadeh, Marjan, Chee, Chin Fei, Ramesh, Singh
Format: Article
Published: Elsevier 2022
Subjects:
TJ Mechanical engineering and machinery
Online Access:http://eprints.um.edu.my/42163/
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spelling my.um.eprints.421632023-10-16T03:17:17Z http://eprints.um.edu.my/42163/ Effect of carbonate content on the in vitro bioactivity of carbonated hydroxyapatite Safarzadeh, Marjan Chee, Chin Fei Ramesh, Singh TJ Mechanical engineering and machinery The effect of carbonate content on the apatite-forming ability of carbonated hydroxyapatite (CHA) in simulated body fluid (SBF) has been investigated. Five different nanocrystalline B-type CHA with carbonate content ranged from 2.01 to 5.25 wt% were prepared, sintered, and assessed for their in vitro bioactivity in SBF solution for 7-weeks under static conditions at 36.5 degrees C. The formation of the apatite layer and the surface morphology of CHA were examined by using a scanning electron microscope (FESEM) at week 1, 3, and 7 of SBF immersion, respectively. The Ca/P molar ratio of the CHA was determined by X-ray fluorescence (XRF). In addition, the sample weight changes and the pH of the SBF solution were measured. The results show that the formation of apatite layer depends on the carbonate content of CHA. Increasing the carbonate content caused significant increases in the surface area of CHA and the rate of apatite formation. Weight loss was observed for all CHA samples during the first week of SBF immersion, and thereafter followed by weight regain weekly until week 7. The changes in the pH of SBF and the Ca/P molar ratio were proportional to the carbonate content of CHA. This study thus highlights the importance of determining carbonate content aspect that govern the bioactivity of CHA. Elsevier 2022-07-01 Article PeerReviewed Safarzadeh, Marjan and Chee, Chin Fei and Ramesh, Singh (2022) Effect of carbonate content on the in vitro bioactivity of carbonated hydroxyapatite. Ceramics International, 48 (13). pp. 18174-18179. ISSN 0272-8842, DOI https://doi.org/10.1016/j.ceramint.2022.03.076 <https://doi.org/10.1016/j.ceramint.2022.03.076>. 10.1016/j.ceramint.2022.03.076
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic TJ Mechanical engineering and machinery
spellingShingle TJ Mechanical engineering and machinery
Safarzadeh, Marjan
Chee, Chin Fei
Ramesh, Singh
Effect of carbonate content on the in vitro bioactivity of carbonated hydroxyapatite
description The effect of carbonate content on the apatite-forming ability of carbonated hydroxyapatite (CHA) in simulated body fluid (SBF) has been investigated. Five different nanocrystalline B-type CHA with carbonate content ranged from 2.01 to 5.25 wt% were prepared, sintered, and assessed for their in vitro bioactivity in SBF solution for 7-weeks under static conditions at 36.5 degrees C. The formation of the apatite layer and the surface morphology of CHA were examined by using a scanning electron microscope (FESEM) at week 1, 3, and 7 of SBF immersion, respectively. The Ca/P molar ratio of the CHA was determined by X-ray fluorescence (XRF). In addition, the sample weight changes and the pH of the SBF solution were measured. The results show that the formation of apatite layer depends on the carbonate content of CHA. Increasing the carbonate content caused significant increases in the surface area of CHA and the rate of apatite formation. Weight loss was observed for all CHA samples during the first week of SBF immersion, and thereafter followed by weight regain weekly until week 7. The changes in the pH of SBF and the Ca/P molar ratio were proportional to the carbonate content of CHA. This study thus highlights the importance of determining carbonate content aspect that govern the bioactivity of CHA.
format Article
author Safarzadeh, Marjan
Chee, Chin Fei
Ramesh, Singh
author_facet Safarzadeh, Marjan
Chee, Chin Fei
Ramesh, Singh
author_sort Safarzadeh, Marjan
title Effect of carbonate content on the in vitro bioactivity of carbonated hydroxyapatite
title_short Effect of carbonate content on the in vitro bioactivity of carbonated hydroxyapatite
title_full Effect of carbonate content on the in vitro bioactivity of carbonated hydroxyapatite
title_fullStr Effect of carbonate content on the in vitro bioactivity of carbonated hydroxyapatite
title_full_unstemmed Effect of carbonate content on the in vitro bioactivity of carbonated hydroxyapatite
title_sort effect of carbonate content on the in vitro bioactivity of carbonated hydroxyapatite
publisher Elsevier
publishDate 2022
url http://eprints.um.edu.my/42163/
_version_ 1781704603955363840
score 13.211869

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