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Isolation and characterization of werneria chromene and dihydroxyacidissimol from Burkillanthus malaccensis (Ridl.) Swingle

The secondary metabolites of endemic plants from the Rutaceae family, such as Burkillanthus malaccensis (Ridl.) Swingle from the rainforest of Malaysia, has not been studied. Burkillanthus malaccensis (Ridl.) Swingle may produce antibacterial and antibiotic-potentiating secondary metabolites. Hexane...

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Main Authors:	Zulkipli, Masyitah, Mahbub, Nuzum, Fatima, Ayesha, Wan-Lin, Stefanie Lim, Khoo, Teng-Jin, Mahboob, Tooba, Rajagopal, Mogana, Samudi, Chandramathi, Kathirvalu, Gheetanjali, Abdullah, Nor Hayati, Pinho, Ana Rita, Oliveira, Sonia M. R., Pereira, Maria de Lourdes, Rahmatullah, Mohammed, Hasan, Anamul, Paul, Alok K., Butler, Mark S., Nawaz, Muhammad, Wilairatana, Polrat, Nissapatorn, Veeranoot, Wiart, Christophe
Format:	Article
Published:	MDPI 2022
Subjects:	QR Microbiology R Medicine (General)
Online Access:	http://eprints.um.edu.my/42154/
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spelling	my.um.eprints.421542023-10-13T08:43:26Z http://eprints.um.edu.my/42154/ Isolation and characterization of werneria chromene and dihydroxyacidissimol from Burkillanthus malaccensis (Ridl.) Swingle Zulkipli, Masyitah Mahbub, Nuzum Fatima, Ayesha Wan-Lin, Stefanie Lim Khoo, Teng-Jin Mahboob, Tooba Rajagopal, Mogana Samudi, Chandramathi Kathirvalu, Gheetanjali Abdullah, Nor Hayati Pinho, Ana Rita Oliveira, Sonia M. R. Pereira, Maria de Lourdes Rahmatullah, Mohammed Hasan, Anamul Paul, Alok K. Butler, Mark S. Nawaz, Muhammad Wilairatana, Polrat Nissapatorn, Veeranoot Wiart, Christophe QR Microbiology R Medicine (General) The secondary metabolites of endemic plants from the Rutaceae family, such as Burkillanthus malaccensis (Ridl.) Swingle from the rainforest of Malaysia, has not been studied. Burkillanthus malaccensis (Ridl.) Swingle may produce antibacterial and antibiotic-potentiating secondary metabolites. Hexane, chloroform, and methanol extracts of leaves, bark, wood, pericarps, and endocarps were tested against bacteria by broth microdilution assay and their antibiotic-potentiating activities. Chromatographic separations of hexane extracts of seeds were conducted to investigate effective phytochemicals and their antibacterial activities. Molecular docking studies of werneria chromene and dihydroxyacidissiminol against SARS-CoV-2 virus infection were conducted using AutoDock Vina. The methanol extract of bark inhibited the growth of Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa with the minimum inhibitory concentration of 250, 500, and 250 mu g/mL, respectively. The chloroform extract of endocarps potentiated the activity of imipenem against imipenem-resistant Acinetobacter baumannii. The hexane extract of seeds increased the sensitivity of P. aeruginosa against ciprofloxacin and levofloxacin. The hexane extract of seeds and chloroform extract of endocarps were chromatographed, yielding werneria chromene and dihydroxyacidissiminol. Werneria chromene was bacteriostatic for P. aeruginosa and P. putida, with MIC/MBC values of 1000 > 1000 mu g/mL. Dihydroxyacidissiminol showed the predicted binding energies of -8.1, -7.6, -7.0, and -7.5 kcal/mol with cathepsin L, nsp13 helicase, SARS-CoV-2 main protease, and SARS-CoV-2 spike protein receptor-binding domain S-RBD. Burkillanthus malaccensis (Ridl.) Swingle can be a potential source of natural products with antibiotic-potentiating activity and that are anti-SARS-CoV-2. MDPI 2022-06 Article PeerReviewed Zulkipli, Masyitah and Mahbub, Nuzum and Fatima, Ayesha and Wan-Lin, Stefanie Lim and Khoo, Teng-Jin and Mahboob, Tooba and Rajagopal, Mogana and Samudi, Chandramathi and Kathirvalu, Gheetanjali and Abdullah, Nor Hayati and Pinho, Ana Rita and Oliveira, Sonia M. R. and Pereira, Maria de Lourdes and Rahmatullah, Mohammed and Hasan, Anamul and Paul, Alok K. and Butler, Mark S. and Nawaz, Muhammad and Wilairatana, Polrat and Nissapatorn, Veeranoot and Wiart, Christophe (2022) Isolation and characterization of werneria chromene and dihydroxyacidissimol from Burkillanthus malaccensis (Ridl.) Swingle. Plants-Basel, 11 (11). ISSN 2223-7747, DOI https://doi.org/10.3390/plants11111388 <https://doi.org/10.3390/plants11111388>. 10.3390/plants11111388
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	QR Microbiology R Medicine (General)
spellingShingle	QR Microbiology R Medicine (General) Zulkipli, Masyitah Mahbub, Nuzum Fatima, Ayesha Wan-Lin, Stefanie Lim Khoo, Teng-Jin Mahboob, Tooba Rajagopal, Mogana Samudi, Chandramathi Kathirvalu, Gheetanjali Abdullah, Nor Hayati Pinho, Ana Rita Oliveira, Sonia M. R. Pereira, Maria de Lourdes Rahmatullah, Mohammed Hasan, Anamul Paul, Alok K. Butler, Mark S. Nawaz, Muhammad Wilairatana, Polrat Nissapatorn, Veeranoot Wiart, Christophe Isolation and characterization of werneria chromene and dihydroxyacidissimol from Burkillanthus malaccensis (Ridl.) Swingle
description	The secondary metabolites of endemic plants from the Rutaceae family, such as Burkillanthus malaccensis (Ridl.) Swingle from the rainforest of Malaysia, has not been studied. Burkillanthus malaccensis (Ridl.) Swingle may produce antibacterial and antibiotic-potentiating secondary metabolites. Hexane, chloroform, and methanol extracts of leaves, bark, wood, pericarps, and endocarps were tested against bacteria by broth microdilution assay and their antibiotic-potentiating activities. Chromatographic separations of hexane extracts of seeds were conducted to investigate effective phytochemicals and their antibacterial activities. Molecular docking studies of werneria chromene and dihydroxyacidissiminol against SARS-CoV-2 virus infection were conducted using AutoDock Vina. The methanol extract of bark inhibited the growth of Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa with the minimum inhibitory concentration of 250, 500, and 250 mu g/mL, respectively. The chloroform extract of endocarps potentiated the activity of imipenem against imipenem-resistant Acinetobacter baumannii. The hexane extract of seeds increased the sensitivity of P. aeruginosa against ciprofloxacin and levofloxacin. The hexane extract of seeds and chloroform extract of endocarps were chromatographed, yielding werneria chromene and dihydroxyacidissiminol. Werneria chromene was bacteriostatic for P. aeruginosa and P. putida, with MIC/MBC values of 1000 > 1000 mu g/mL. Dihydroxyacidissiminol showed the predicted binding energies of -8.1, -7.6, -7.0, and -7.5 kcal/mol with cathepsin L, nsp13 helicase, SARS-CoV-2 main protease, and SARS-CoV-2 spike protein receptor-binding domain S-RBD. Burkillanthus malaccensis (Ridl.) Swingle can be a potential source of natural products with antibiotic-potentiating activity and that are anti-SARS-CoV-2.
format	Article
author	Zulkipli, Masyitah Mahbub, Nuzum Fatima, Ayesha Wan-Lin, Stefanie Lim Khoo, Teng-Jin Mahboob, Tooba Rajagopal, Mogana Samudi, Chandramathi Kathirvalu, Gheetanjali Abdullah, Nor Hayati Pinho, Ana Rita Oliveira, Sonia M. R. Pereira, Maria de Lourdes Rahmatullah, Mohammed Hasan, Anamul Paul, Alok K. Butler, Mark S. Nawaz, Muhammad Wilairatana, Polrat Nissapatorn, Veeranoot Wiart, Christophe
author_facet	Zulkipli, Masyitah Mahbub, Nuzum Fatima, Ayesha Wan-Lin, Stefanie Lim Khoo, Teng-Jin Mahboob, Tooba Rajagopal, Mogana Samudi, Chandramathi Kathirvalu, Gheetanjali Abdullah, Nor Hayati Pinho, Ana Rita Oliveira, Sonia M. R. Pereira, Maria de Lourdes Rahmatullah, Mohammed Hasan, Anamul Paul, Alok K. Butler, Mark S. Nawaz, Muhammad Wilairatana, Polrat Nissapatorn, Veeranoot Wiart, Christophe
author_sort	Zulkipli, Masyitah
title	Isolation and characterization of werneria chromene and dihydroxyacidissimol from Burkillanthus malaccensis (Ridl.) Swingle
title_short	Isolation and characterization of werneria chromene and dihydroxyacidissimol from Burkillanthus malaccensis (Ridl.) Swingle
title_full	Isolation and characterization of werneria chromene and dihydroxyacidissimol from Burkillanthus malaccensis (Ridl.) Swingle
title_fullStr	Isolation and characterization of werneria chromene and dihydroxyacidissimol from Burkillanthus malaccensis (Ridl.) Swingle
title_full_unstemmed	Isolation and characterization of werneria chromene and dihydroxyacidissimol from Burkillanthus malaccensis (Ridl.) Swingle
title_sort	isolation and characterization of werneria chromene and dihydroxyacidissimol from burkillanthus malaccensis (ridl.) swingle
publisher	MDPI
publishDate	2022
url	http://eprints.um.edu.my/42154/
_version_	1781704602617380864
score	13.211869

Isolation and characterization of werneria chromene and dihydroxyacidissimol from Burkillanthus malaccensis (Ridl.) Swingle

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