Staff View: Outcomes of patients with EGFR-mutant advanced NSCLC in a developing country in Southeast Asia

Outcomes of patients with EGFR-mutant advanced NSCLC in a developing country in Southeast Asia

Background: Although first-and second-generation EGFR TKIs are considered first-line treatment in EGFRm+ NSCLC, most patients develop resistance and progress, commonly, EGFR T790M mutation. The third-generation EGFR-TKI has demonstrated efficacy in patients with progressive disease harboring the T79...

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Main Authors:	How, Soon Hin, Liam, Chong Kin, Abidin, Muhammad Adil Zainal, Hasbullah, Harissa H., Tho, Lye Mun, Ho, Gwo Fuang, Nor, Ibtisam Muhamad, Pang, Yong Kek, Ho, Kean Fatt, Thiagarajan, Muthukkumaran, Ariffin, Roziana, Samsudin, Azlina, Omar, Azza, Tan, Sin Nee, Ong, Choo Khoon, Soon, Sing Yang, Poh, Mau Ern
Format:	Article
Published:	Dove Medical Press LTD 2022
Subjects:	R Medicine
Online Access:	http://eprints.um.edu.my/42092/
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spelling	my.um.eprints.420922023-10-13T03:19:11Z http://eprints.um.edu.my/42092/ Outcomes of patients with EGFR-mutant advanced NSCLC in a developing country in Southeast Asia How, Soon Hin Liam, Chong Kin Abidin, Muhammad Adil Zainal Hasbullah, Harissa H. Tho, Lye Mun Ho, Gwo Fuang Nor, Ibtisam Muhamad Pang, Yong Kek Ho, Kean Fatt Thiagarajan, Muthukkumaran Ariffin, Roziana Samsudin, Azlina Omar, Azza Tan, Sin Nee Ong, Choo Khoon Soon, Sing Yang Poh, Mau Ern R Medicine Background: Although first-and second-generation EGFR TKIs are considered first-line treatment in EGFRm+ NSCLC, most patients develop resistance and progress, commonly, EGFR T790M mutation. The third-generation EGFR-TKI has demonstrated efficacy in patients with progressive disease harboring the T790M mutation and in the first-line setting, bypassing this mode of resistance. The primary objectives of this study are to describe the proportion of EGFRm+ NSCLC patients treated with first-, second-and third-generation EGFR TKIs, and cytotoxic chemotherapy in the first-line setting, and the time on treatment for each category. Secondary objectives are to determine the dropout rate, the rates for T790M mutation testing at disease progression and the type of subsequent treatment. Methods: This multicenter retrospective study utilized data from the Malaysian Lung Cancer Registry that actively registers all lung cancer patients >= 18 years, with primary lung cancer confirmed histologically or cytologically. All patients diagnosed with advanced stages (ie stages IIIB, IIIC and IV) EGFRm+ NSCLC from 1st of January 2015 to 31st December 2019 were included. Results: Of 406 patients with EGFRm+ NCSLC, 351 were treated. Types of first-line treatment were as follows: EGFR-TKIs (first generation - 54.1%, second generation - 25.6% and third-generation - 12.5%) and chemotherapy (7.7%). The median time of treatment for each generation of EGFR-TKI was 12 months, 12 months and 24 months, and 2 months for chemotherapy. The dropout rate was 28.7% (n = 101). Nearly half (49.4%) of patients who were on first-or second-generation EGFR-TKI had further genetic testing via liquid or tissue biopsies upon disease progression. About 24.9% of those who developed disease progression after first-or second-generation EGFR TKI were started on a third-generation EGFR TKI. Conclusion: In the real-world, the management of EGFRm+ advanced NSCLC patients in an Asian cost-restrictive setting may adversely affect the choice of first-line therapy, time on each line of treatment and subsequently the overall survival of patients. Dove Medical Press LTD 2022 Article PeerReviewed How, Soon Hin and Liam, Chong Kin and Abidin, Muhammad Adil Zainal and Hasbullah, Harissa H. and Tho, Lye Mun and Ho, Gwo Fuang and Nor, Ibtisam Muhamad and Pang, Yong Kek and Ho, Kean Fatt and Thiagarajan, Muthukkumaran and Ariffin, Roziana and Samsudin, Azlina and Omar, Azza and Tan, Sin Nee and Ong, Choo Khoon and Soon, Sing Yang and Poh, Mau Ern (2022) Outcomes of patients with EGFR-mutant advanced NSCLC in a developing country in Southeast Asia. Cancer Management And Research, 14. pp. 1995-2005. ISSN 1179-1322, DOI https://doi.org/10.2147/CMAR.S364713 <https://doi.org/10.2147/CMAR.S364713>. 10.2147/CMAR.S364713
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	R Medicine
spellingShingle	R Medicine How, Soon Hin Liam, Chong Kin Abidin, Muhammad Adil Zainal Hasbullah, Harissa H. Tho, Lye Mun Ho, Gwo Fuang Nor, Ibtisam Muhamad Pang, Yong Kek Ho, Kean Fatt Thiagarajan, Muthukkumaran Ariffin, Roziana Samsudin, Azlina Omar, Azza Tan, Sin Nee Ong, Choo Khoon Soon, Sing Yang Poh, Mau Ern Outcomes of patients with EGFR-mutant advanced NSCLC in a developing country in Southeast Asia
description	Background: Although first-and second-generation EGFR TKIs are considered first-line treatment in EGFRm+ NSCLC, most patients develop resistance and progress, commonly, EGFR T790M mutation. The third-generation EGFR-TKI has demonstrated efficacy in patients with progressive disease harboring the T790M mutation and in the first-line setting, bypassing this mode of resistance. The primary objectives of this study are to describe the proportion of EGFRm+ NSCLC patients treated with first-, second-and third-generation EGFR TKIs, and cytotoxic chemotherapy in the first-line setting, and the time on treatment for each category. Secondary objectives are to determine the dropout rate, the rates for T790M mutation testing at disease progression and the type of subsequent treatment. Methods: This multicenter retrospective study utilized data from the Malaysian Lung Cancer Registry that actively registers all lung cancer patients >= 18 years, with primary lung cancer confirmed histologically or cytologically. All patients diagnosed with advanced stages (ie stages IIIB, IIIC and IV) EGFRm+ NSCLC from 1st of January 2015 to 31st December 2019 were included. Results: Of 406 patients with EGFRm+ NCSLC, 351 were treated. Types of first-line treatment were as follows: EGFR-TKIs (first generation - 54.1%, second generation - 25.6% and third-generation - 12.5%) and chemotherapy (7.7%). The median time of treatment for each generation of EGFR-TKI was 12 months, 12 months and 24 months, and 2 months for chemotherapy. The dropout rate was 28.7% (n = 101). Nearly half (49.4%) of patients who were on first-or second-generation EGFR-TKI had further genetic testing via liquid or tissue biopsies upon disease progression. About 24.9% of those who developed disease progression after first-or second-generation EGFR TKI were started on a third-generation EGFR TKI. Conclusion: In the real-world, the management of EGFRm+ advanced NSCLC patients in an Asian cost-restrictive setting may adversely affect the choice of first-line therapy, time on each line of treatment and subsequently the overall survival of patients.
format	Article
author	How, Soon Hin Liam, Chong Kin Abidin, Muhammad Adil Zainal Hasbullah, Harissa H. Tho, Lye Mun Ho, Gwo Fuang Nor, Ibtisam Muhamad Pang, Yong Kek Ho, Kean Fatt Thiagarajan, Muthukkumaran Ariffin, Roziana Samsudin, Azlina Omar, Azza Tan, Sin Nee Ong, Choo Khoon Soon, Sing Yang Poh, Mau Ern
author_facet	How, Soon Hin Liam, Chong Kin Abidin, Muhammad Adil Zainal Hasbullah, Harissa H. Tho, Lye Mun Ho, Gwo Fuang Nor, Ibtisam Muhamad Pang, Yong Kek Ho, Kean Fatt Thiagarajan, Muthukkumaran Ariffin, Roziana Samsudin, Azlina Omar, Azza Tan, Sin Nee Ong, Choo Khoon Soon, Sing Yang Poh, Mau Ern
author_sort	How, Soon Hin
title	Outcomes of patients with EGFR-mutant advanced NSCLC in a developing country in Southeast Asia
title_short	Outcomes of patients with EGFR-mutant advanced NSCLC in a developing country in Southeast Asia
title_full	Outcomes of patients with EGFR-mutant advanced NSCLC in a developing country in Southeast Asia
title_fullStr	Outcomes of patients with EGFR-mutant advanced NSCLC in a developing country in Southeast Asia
title_full_unstemmed	Outcomes of patients with EGFR-mutant advanced NSCLC in a developing country in Southeast Asia
title_sort	outcomes of patients with egfr-mutant advanced nsclc in a developing country in southeast asia
publisher	Dove Medical Press LTD
publishDate	2022
url	http://eprints.um.edu.my/42092/
_version_	1781704594022203392
score	13.211869

Outcomes of patients with EGFR-mutant advanced NSCLC in a developing country in Southeast Asia

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