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Small intestinal bacterial overgrowth In various functional gastrointestinal disorders: A case-control study

Introduction Small intestinal bacterial overgrowth (SIBO) is prevalent in irritable bowel syndrome (IBS), but its' association with other functional gastrointestinal disorders (FGIDs) is less certain. This study aimed to explore SIBO in a multi-racial Asian population with various FGIDs compare...

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Main Authors: Chuah, Kee Huat, Wong, Mung Seong, Tan, Phei Oon, Lim, Sze Zee, Beh, Keng Hau, Chong, Sufian Chern Siong, Zulkifli, Khairil Khuzaini, Thalha, Abdul Malik, Mahadeva, Sanjiv, Lee, Yeong Yeh
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Published: Springer 2022
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R Medicine (General)
Online Access:http://eprints.um.edu.my/41818/
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spelling my.um.eprints.418182023-10-20T09:32:10Z http://eprints.um.edu.my/41818/ Small intestinal bacterial overgrowth In various functional gastrointestinal disorders: A case-control study Chuah, Kee Huat Wong, Mung Seong Tan, Phei Oon Lim, Sze Zee Beh, Keng Hau Chong, Sufian Chern Siong Zulkifli, Khairil Khuzaini Thalha, Abdul Malik Mahadeva, Sanjiv Lee, Yeong Yeh R Medicine (General) Introduction Small intestinal bacterial overgrowth (SIBO) is prevalent in irritable bowel syndrome (IBS), but its' association with other functional gastrointestinal disorders (FGIDs) is less certain. This study aimed to explore SIBO in a multi-racial Asian population with various FGIDs compared to non-FGID controls. Methodology Consecutive Asian adults with Rome III diagnosed common FGIDs (functional dyspepsia/FD, IBS and functional constipation/FC) and non-FGID controls were subjected to glucose breath testing, with hydrogen (H2) and methane (CH4) levels determined. Results A total of 244 participants (FGIDs n = 186, controls n = 58, median age 45 years, males 36%, Malay ethnicity 76%) were recruited. FGIDs had a higher prevalence trend of SIBO compared to controls (16% FGIDs vs. 10% controls, p = 0.278) with 14% in FD, 18% in IBS and 17% in FC. Compared to controls, SIBO was associated with diarrhoea-predominant IBS (IBS-D) (24% vs. 10%, P = 0.050) but not with other types of FGIDs. IBS-D remained an independent predictor of SIBO (OR = 2.864, 95% CI 1.160-7.071, p = 0.023) but not PPI usage nor history of diabetes (both p > 0.050) at multivariate analysis. Compared to controls, SIBO in IBS-D was associated with an elevated H-2 level (>= 20 ppm from baseline) (18% vs. 3%, p = 0.017), but not CH4 levels (>= 10 ppm) (9% vs. 7%, p = 0.493). In addition, no difference was found in the prevalence of methane-positive SIBO between chronic constipation (constipation-predominant IBS and FC) compared to controls (9% vs. 7%, P = 0.466). Conclusion SIBO is prevalent amongst multi-ethnic Asian adults with and without FGIDs. Amongst various FGIDs, only IBS-D is significantly associated with SIBO. Springer 2022-08 Article PeerReviewed Chuah, Kee Huat and Wong, Mung Seong and Tan, Phei Oon and Lim, Sze Zee and Beh, Keng Hau and Chong, Sufian Chern Siong and Zulkifli, Khairil Khuzaini and Thalha, Abdul Malik and Mahadeva, Sanjiv and Lee, Yeong Yeh (2022) Small intestinal bacterial overgrowth In various functional gastrointestinal disorders: A case-control study. Digestive Diseases and Sciences, 67 (8). pp. 3881-3889. ISSN 0163-2116, DOI https://doi.org/10.1007/s10620-021-07227-4 <https://doi.org/10.1007/s10620-021-07227-4>. 10.1007/s10620-021-07227-4
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine (General)
spellingShingle R Medicine (General)
Chuah, Kee Huat
Wong, Mung Seong
Tan, Phei Oon
Lim, Sze Zee
Beh, Keng Hau
Chong, Sufian Chern Siong
Zulkifli, Khairil Khuzaini
Thalha, Abdul Malik
Mahadeva, Sanjiv
Lee, Yeong Yeh
Small intestinal bacterial overgrowth In various functional gastrointestinal disorders: A case-control study
description Introduction Small intestinal bacterial overgrowth (SIBO) is prevalent in irritable bowel syndrome (IBS), but its' association with other functional gastrointestinal disorders (FGIDs) is less certain. This study aimed to explore SIBO in a multi-racial Asian population with various FGIDs compared to non-FGID controls. Methodology Consecutive Asian adults with Rome III diagnosed common FGIDs (functional dyspepsia/FD, IBS and functional constipation/FC) and non-FGID controls were subjected to glucose breath testing, with hydrogen (H2) and methane (CH4) levels determined. Results A total of 244 participants (FGIDs n = 186, controls n = 58, median age 45 years, males 36%, Malay ethnicity 76%) were recruited. FGIDs had a higher prevalence trend of SIBO compared to controls (16% FGIDs vs. 10% controls, p = 0.278) with 14% in FD, 18% in IBS and 17% in FC. Compared to controls, SIBO was associated with diarrhoea-predominant IBS (IBS-D) (24% vs. 10%, P = 0.050) but not with other types of FGIDs. IBS-D remained an independent predictor of SIBO (OR = 2.864, 95% CI 1.160-7.071, p = 0.023) but not PPI usage nor history of diabetes (both p > 0.050) at multivariate analysis. Compared to controls, SIBO in IBS-D was associated with an elevated H-2 level (>= 20 ppm from baseline) (18% vs. 3%, p = 0.017), but not CH4 levels (>= 10 ppm) (9% vs. 7%, p = 0.493). In addition, no difference was found in the prevalence of methane-positive SIBO between chronic constipation (constipation-predominant IBS and FC) compared to controls (9% vs. 7%, P = 0.466). Conclusion SIBO is prevalent amongst multi-ethnic Asian adults with and without FGIDs. Amongst various FGIDs, only IBS-D is significantly associated with SIBO.
format Article
author Chuah, Kee Huat
Wong, Mung Seong
Tan, Phei Oon
Lim, Sze Zee
Beh, Keng Hau
Chong, Sufian Chern Siong
Zulkifli, Khairil Khuzaini
Thalha, Abdul Malik
Mahadeva, Sanjiv
Lee, Yeong Yeh
author_facet Chuah, Kee Huat
Wong, Mung Seong
Tan, Phei Oon
Lim, Sze Zee
Beh, Keng Hau
Chong, Sufian Chern Siong
Zulkifli, Khairil Khuzaini
Thalha, Abdul Malik
Mahadeva, Sanjiv
Lee, Yeong Yeh
author_sort Chuah, Kee Huat
title Small intestinal bacterial overgrowth In various functional gastrointestinal disorders: A case-control study
title_short Small intestinal bacterial overgrowth In various functional gastrointestinal disorders: A case-control study
title_full Small intestinal bacterial overgrowth In various functional gastrointestinal disorders: A case-control study
title_fullStr Small intestinal bacterial overgrowth In various functional gastrointestinal disorders: A case-control study
title_full_unstemmed Small intestinal bacterial overgrowth In various functional gastrointestinal disorders: A case-control study
title_sort small intestinal bacterial overgrowth in various functional gastrointestinal disorders: a case-control study
publisher Springer
publishDate 2022
url http://eprints.um.edu.my/41818/
_version_ 1781704560070361088
score 13.211869

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