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Incidence of allopurinol-induced severe cutaneous adverse drug reaction in Malaysia

Aims Allopurinol is known to cause severe cutaneous adverse drug reactions (SCAR) in Malaysia. However, the incidence of allopurinol-induced SCAR is unknown. Therefore, we aimed to determine the incidence of allopurinol-induced SCAR in Malaysia over 5 years from 2015 to 2019. Methods This retrospect...

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Main Authors: Ng, Wei Leik, Lim, Kheng Seang, Hariraj, Vidhya, Lee, Sing Chet, Wo, Wee Kee, Ramli, Azuana, Lai, Pauline Siew Mei, Fong, Si Lei, Lim, Jing Ran
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Published: Blackwell Publishing 2022
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RS Pharmacy and materia medica
Online Access:http://eprints.um.edu.my/41745/
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spelling my.um.eprints.417452023-10-14T06:27:11Z http://eprints.um.edu.my/41745/ Incidence of allopurinol-induced severe cutaneous adverse drug reaction in Malaysia Ng, Wei Leik Lim, Kheng Seang Hariraj, Vidhya Lee, Sing Chet Wo, Wee Kee Ramli, Azuana Lai, Pauline Siew Mei Fong, Si Lei Lim, Jing Ran RS Pharmacy and materia medica Aims Allopurinol is known to cause severe cutaneous adverse drug reactions (SCAR) in Malaysia. However, the incidence of allopurinol-induced SCAR is unknown. Therefore, we aimed to determine the incidence of allopurinol-induced SCAR in Malaysia over 5 years from 2015 to 2019. Methods This retrospective analysis was done in collaboration with the National Pharmaceutical Regulatory Agency (NPRA). All allopurinol-induced adverse drug reaction cases reported to NPRA from 2015 to 2019 were extracted. Allopurinol-induced SCAR cases were identified and the incidence over the 5 years was calculated. Results Incidence of allopurinol-induced SCAR averaged at 2.5 cases per 1000 new users over the 5-year period, with a reducing trend from 3.2 per 1000 new users in 2015 to 2.25 per 1000 in 2019; despite the increasing number of adverse drug reaction cases being reported over the years. Stevens-Johnson syndrome was the commonest form of allopurinol-induced SCAR reported, at 143 cases (46.8% of total SCAR reported). Among Malaysia's 3 main ethnicities, the Chinese had the highest percentages of allopurinol-induced SCAR when compared to the Bumiputera and Indians (3.18 x 10(-4)%). Conclusion The estimated incidence of allopurinol-induced SCAR in Malaysia from 2015 to 2019 was 2.5 cases per 1000 new users. This figure is consistent with the incidence reported in other Asian countries, namely Taiwan and Thailand. Blackwell Publishing 2022-08 Article PeerReviewed Ng, Wei Leik and Lim, Kheng Seang and Hariraj, Vidhya and Lee, Sing Chet and Wo, Wee Kee and Ramli, Azuana and Lai, Pauline Siew Mei and Fong, Si Lei and Lim, Jing Ran (2022) Incidence of allopurinol-induced severe cutaneous adverse drug reaction in Malaysia. British Journal of Clinical Pharmacology, 88 (8). pp. 3782-3788. ISSN 0306-5251, DOI https://doi.org/10.1111/bcp.15327 <https://doi.org/10.1111/bcp.15327>. 10.1111/bcp.15327
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic RS Pharmacy and materia medica
spellingShingle RS Pharmacy and materia medica
Ng, Wei Leik
Lim, Kheng Seang
Hariraj, Vidhya
Lee, Sing Chet
Wo, Wee Kee
Ramli, Azuana
Lai, Pauline Siew Mei
Fong, Si Lei
Lim, Jing Ran
Incidence of allopurinol-induced severe cutaneous adverse drug reaction in Malaysia
description Aims Allopurinol is known to cause severe cutaneous adverse drug reactions (SCAR) in Malaysia. However, the incidence of allopurinol-induced SCAR is unknown. Therefore, we aimed to determine the incidence of allopurinol-induced SCAR in Malaysia over 5 years from 2015 to 2019. Methods This retrospective analysis was done in collaboration with the National Pharmaceutical Regulatory Agency (NPRA). All allopurinol-induced adverse drug reaction cases reported to NPRA from 2015 to 2019 were extracted. Allopurinol-induced SCAR cases were identified and the incidence over the 5 years was calculated. Results Incidence of allopurinol-induced SCAR averaged at 2.5 cases per 1000 new users over the 5-year period, with a reducing trend from 3.2 per 1000 new users in 2015 to 2.25 per 1000 in 2019; despite the increasing number of adverse drug reaction cases being reported over the years. Stevens-Johnson syndrome was the commonest form of allopurinol-induced SCAR reported, at 143 cases (46.8% of total SCAR reported). Among Malaysia's 3 main ethnicities, the Chinese had the highest percentages of allopurinol-induced SCAR when compared to the Bumiputera and Indians (3.18 x 10(-4)%). Conclusion The estimated incidence of allopurinol-induced SCAR in Malaysia from 2015 to 2019 was 2.5 cases per 1000 new users. This figure is consistent with the incidence reported in other Asian countries, namely Taiwan and Thailand.
format Article
author Ng, Wei Leik
Lim, Kheng Seang
Hariraj, Vidhya
Lee, Sing Chet
Wo, Wee Kee
Ramli, Azuana
Lai, Pauline Siew Mei
Fong, Si Lei
Lim, Jing Ran
author_facet Ng, Wei Leik
Lim, Kheng Seang
Hariraj, Vidhya
Lee, Sing Chet
Wo, Wee Kee
Ramli, Azuana
Lai, Pauline Siew Mei
Fong, Si Lei
Lim, Jing Ran
author_sort Ng, Wei Leik
title Incidence of allopurinol-induced severe cutaneous adverse drug reaction in Malaysia
title_short Incidence of allopurinol-induced severe cutaneous adverse drug reaction in Malaysia
title_full Incidence of allopurinol-induced severe cutaneous adverse drug reaction in Malaysia
title_fullStr Incidence of allopurinol-induced severe cutaneous adverse drug reaction in Malaysia
title_full_unstemmed Incidence of allopurinol-induced severe cutaneous adverse drug reaction in Malaysia
title_sort incidence of allopurinol-induced severe cutaneous adverse drug reaction in malaysia
publisher Blackwell Publishing
publishDate 2022
url http://eprints.um.edu.my/41745/
_version_ 1781704551966965760
score 13.211869

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