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The monkey head mushroom and memory enhancement in Alzheimer's disease

Alzheimer's disease (AD) is a neurodegenerative disorder, and no effective treatments are available to treat this disorder. Therefore, researchers have been investigating Hericium erinaceus, or the monkey head mushroom, an edible medicinal mushroom, as a possible treatment for AD. In this narra...

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Main Authors: Yanshree, ., Yu, Wing Shan, Fung, Man Lung, Lee, Chi Wai, Lim, Lee Wei, Wong, Kah Hui
Format: Article
Published: MDPI 2022
Subjects:
R Medicine (General)
RM Therapeutics. Pharmacology
Online Access:http://eprints.um.edu.my/41584/
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spelling my.um.eprints.415842023-11-08T06:38:46Z http://eprints.um.edu.my/41584/ The monkey head mushroom and memory enhancement in Alzheimer's disease Yanshree, . Yu, Wing Shan Fung, Man Lung Lee, Chi Wai Lim, Lee Wei Wong, Kah Hui R Medicine (General) RM Therapeutics. Pharmacology Alzheimer's disease (AD) is a neurodegenerative disorder, and no effective treatments are available to treat this disorder. Therefore, researchers have been investigating Hericium erinaceus, or the monkey head mushroom, an edible medicinal mushroom, as a possible treatment for AD. In this narrative review, we evaluated six preclinical and three clinical studies of the therapeutic effects of Hericium erinaceus on AD. Preclinical trials have successfully demonstrated that extracts and bioactive compounds of Hericium erinaceus have potential beneficial effects in ameliorating cognitive functioning and behavioral deficits in animal models of AD. A limited number of clinical studies have been conducted and several clinical trials are ongoing, which have thus far shown analogous outcomes to the preclinical studies. Nonetheless, future research on Hericium erinaceus needs to focus on elucidating the specific neuroprotective mechanisms and the target sites in AD. Additionally, standardized treatment parameters and universal regulatory systems need to be established to further ensure treatment safety and efficacy. In conclusion, Hericium erinaceus has therapeutic potential and may facilitate memory enhancement in patients with AD. MDPI 2022-08 Article PeerReviewed Yanshree, . and Yu, Wing Shan and Fung, Man Lung and Lee, Chi Wai and Lim, Lee Wei and Wong, Kah Hui (2022) The monkey head mushroom and memory enhancement in Alzheimer's disease. Cells, 11 (15). ISSN 2073-4409, DOI https://doi.org/10.3390/cells11152284 <https://doi.org/10.3390/cells11152284>. 10.3390/cells11152284
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine (General)
RM Therapeutics. Pharmacology
spellingShingle R Medicine (General)
RM Therapeutics. Pharmacology
Yanshree, .
Yu, Wing Shan
Fung, Man Lung
Lee, Chi Wai
Lim, Lee Wei
Wong, Kah Hui
The monkey head mushroom and memory enhancement in Alzheimer's disease
description Alzheimer's disease (AD) is a neurodegenerative disorder, and no effective treatments are available to treat this disorder. Therefore, researchers have been investigating Hericium erinaceus, or the monkey head mushroom, an edible medicinal mushroom, as a possible treatment for AD. In this narrative review, we evaluated six preclinical and three clinical studies of the therapeutic effects of Hericium erinaceus on AD. Preclinical trials have successfully demonstrated that extracts and bioactive compounds of Hericium erinaceus have potential beneficial effects in ameliorating cognitive functioning and behavioral deficits in animal models of AD. A limited number of clinical studies have been conducted and several clinical trials are ongoing, which have thus far shown analogous outcomes to the preclinical studies. Nonetheless, future research on Hericium erinaceus needs to focus on elucidating the specific neuroprotective mechanisms and the target sites in AD. Additionally, standardized treatment parameters and universal regulatory systems need to be established to further ensure treatment safety and efficacy. In conclusion, Hericium erinaceus has therapeutic potential and may facilitate memory enhancement in patients with AD.
format Article
author Yanshree, .
Yu, Wing Shan
Fung, Man Lung
Lee, Chi Wai
Lim, Lee Wei
Wong, Kah Hui
author_facet Yanshree, .
Yu, Wing Shan
Fung, Man Lung
Lee, Chi Wai
Lim, Lee Wei
Wong, Kah Hui
author_sort Yanshree, .
title The monkey head mushroom and memory enhancement in Alzheimer's disease
title_short The monkey head mushroom and memory enhancement in Alzheimer's disease
title_full The monkey head mushroom and memory enhancement in Alzheimer's disease
title_fullStr The monkey head mushroom and memory enhancement in Alzheimer's disease
title_full_unstemmed The monkey head mushroom and memory enhancement in Alzheimer's disease
title_sort monkey head mushroom and memory enhancement in alzheimer's disease
publisher MDPI
publishDate 2022
url http://eprints.um.edu.my/41584/
_version_ 1783876725325692928
score 13.211869

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