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Zinc(II)-Schiff base complex functionalized on gold nanospheres: Synthesis, characterization, anticancer study and interaction with proteins

Metal complexes functionalized on gold nanoparticles and their biological properties have not been extensively investigated although gold nanoparticles (AuNPs) are one of the most useful nanoparticles in industry and medicine. In our search for novel anticancer compound, a zinc(II) Schiff base compl...

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Main Authors: Ng, Yin Zhuang, Tan, Kong Wai, Chung, Lip Yong, Salim, Fatimah, Low, May Lee, Ooi, Ing Hong, Yip, Foo Win, Ng, Chew Hee
Format: Article
Published: Taylor & Francis 2022
Subjects:
QD Chemistry
Online Access:http://eprints.um.edu.my/41426/
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spelling my.um.eprints.414262023-09-22T03:58:14Z http://eprints.um.edu.my/41426/ Zinc(II)-Schiff base complex functionalized on gold nanospheres: Synthesis, characterization, anticancer study and interaction with proteins Ng, Yin Zhuang Tan, Kong Wai Chung, Lip Yong Salim, Fatimah Low, May Lee Ooi, Ing Hong Yip, Foo Win Ng, Chew Hee QD Chemistry Metal complexes functionalized on gold nanoparticles and their biological properties have not been extensively investigated although gold nanoparticles (AuNPs) are one of the most useful nanoparticles in industry and medicine. In our search for novel anticancer compound, a zinc(II) Schiff base complex was conjugated to gold nanoparticles to yield AuNP-TA-Zn(salenphen)](n) conjugate (n = number of linked Zn complex units; TA = thioctic acid). This resultant conjugate was characterized by FTIR, UV-visible and fluorescence spectroscopic techniques, and analyzed by zetasizer and transmission electron microscopy (TEM). TEM analysis shows these conjugate particles to be spherical with average dimension of 17 nm. The loading factor n was found to be 1790. Their interaction with bovine serum albumin and 20S proteasome, together with their permeability and anticancer studies, are reported herein. The extremely high cytotoxicity of the nanogold conjugate towards breast and colon cancer cells, compared to cisplatin, could be attributed to the high loading of the moderate anticancer Zn(salenphen)] on the gold nanospheres and the generation of intracellular reactive oxygen species. Its selective proteasome inhibition of trypsin-like site suggests its usefulness against Plasmodium falciparum. It therefore has great potential as both anticancer and antimalarial drug. Taylor & Francis 2022-09 Article PeerReviewed Ng, Yin Zhuang and Tan, Kong Wai and Chung, Lip Yong and Salim, Fatimah and Low, May Lee and Ooi, Ing Hong and Yip, Foo Win and Ng, Chew Hee (2022) Zinc(II)-Schiff base complex functionalized on gold nanospheres: Synthesis, characterization, anticancer study and interaction with proteins. Journal of Coordination Chemistry, 75 (9-10). pp. 1303-1324. ISSN 0095-8972, DOI https://doi.org/10.1080/00958972.2022.2097869 <https://doi.org/10.1080/00958972.2022.2097869>. 10.1080/00958972.2022.2097869
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QD Chemistry
spellingShingle QD Chemistry
Ng, Yin Zhuang
Tan, Kong Wai
Chung, Lip Yong
Salim, Fatimah
Low, May Lee
Ooi, Ing Hong
Yip, Foo Win
Ng, Chew Hee
Zinc(II)-Schiff base complex functionalized on gold nanospheres: Synthesis, characterization, anticancer study and interaction with proteins
description Metal complexes functionalized on gold nanoparticles and their biological properties have not been extensively investigated although gold nanoparticles (AuNPs) are one of the most useful nanoparticles in industry and medicine. In our search for novel anticancer compound, a zinc(II) Schiff base complex was conjugated to gold nanoparticles to yield AuNP-TA-Zn(salenphen)](n) conjugate (n = number of linked Zn complex units; TA = thioctic acid). This resultant conjugate was characterized by FTIR, UV-visible and fluorescence spectroscopic techniques, and analyzed by zetasizer and transmission electron microscopy (TEM). TEM analysis shows these conjugate particles to be spherical with average dimension of 17 nm. The loading factor n was found to be 1790. Their interaction with bovine serum albumin and 20S proteasome, together with their permeability and anticancer studies, are reported herein. The extremely high cytotoxicity of the nanogold conjugate towards breast and colon cancer cells, compared to cisplatin, could be attributed to the high loading of the moderate anticancer Zn(salenphen)] on the gold nanospheres and the generation of intracellular reactive oxygen species. Its selective proteasome inhibition of trypsin-like site suggests its usefulness against Plasmodium falciparum. It therefore has great potential as both anticancer and antimalarial drug.
format Article
author Ng, Yin Zhuang
Tan, Kong Wai
Chung, Lip Yong
Salim, Fatimah
Low, May Lee
Ooi, Ing Hong
Yip, Foo Win
Ng, Chew Hee
author_facet Ng, Yin Zhuang
Tan, Kong Wai
Chung, Lip Yong
Salim, Fatimah
Low, May Lee
Ooi, Ing Hong
Yip, Foo Win
Ng, Chew Hee
author_sort Ng, Yin Zhuang
title Zinc(II)-Schiff base complex functionalized on gold nanospheres: Synthesis, characterization, anticancer study and interaction with proteins
title_short Zinc(II)-Schiff base complex functionalized on gold nanospheres: Synthesis, characterization, anticancer study and interaction with proteins
title_full Zinc(II)-Schiff base complex functionalized on gold nanospheres: Synthesis, characterization, anticancer study and interaction with proteins
title_fullStr Zinc(II)-Schiff base complex functionalized on gold nanospheres: Synthesis, characterization, anticancer study and interaction with proteins
title_full_unstemmed Zinc(II)-Schiff base complex functionalized on gold nanospheres: Synthesis, characterization, anticancer study and interaction with proteins
title_sort zinc(ii)-schiff base complex functionalized on gold nanospheres: synthesis, characterization, anticancer study and interaction with proteins
publisher Taylor & Francis
publishDate 2022
url http://eprints.um.edu.my/41426/
_version_ 1778161670904872960
score 13.211869

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