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Angiogenic effect of a nanoniosomal deferoxamine-loaded poly(vinyl alcohol)-Egg white film as a promising wound dressing

Owing to the noticeable increase in the number of patients with impaired wound healing capabilities, developing bioactive wound dressings with supportive physicomechanical and biological properties for clinical wound management has attracted much more attention nowadays. In this regard, engineered d...

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Main Authors: Nour, Shirin, Imani, Rana, Sharifi, Ali Mohammad
Format: Article
Published: Amer Chemical Soc 2022
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R Medicine
Online Access:http://eprints.um.edu.my/41424/
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spelling my.um.eprints.414242023-09-22T03:27:31Z http://eprints.um.edu.my/41424/ Angiogenic effect of a nanoniosomal deferoxamine-loaded poly(vinyl alcohol)-Egg white film as a promising wound dressing Nour, Shirin Imani, Rana Sharifi, Ali Mohammad R Medicine Owing to the noticeable increase in the number of patients with impaired wound healing capabilities, developing bioactive wound dressings with supportive physicomechanical and biological properties for clinical wound management has attracted much more attention nowadays. In this regard, engineered dressings with angiogenesis potential are vital for accelerated tissue regeneration. In the current study, nanoniosomal deferoxamine (DFO)-loaded transparent films of egg white-poly(vinyl alcohol) (PVA/EW/ND) were successfully fabricated at three different PVA/EW ratios (1:0, 1:1, and 1:1.5 wt/wt %) through the thin film hydration and solvent casting methods. The developed films' characterizations were carried out using scanning electron microscopy, Fourier transform infrared spectroscopy analysis, uniaxial tensile strength, water uptake, water vapor transmission rate, in vitro degradation, and drug release. The results demonstrated that the various weight ratios of PVA/EW have a significant effect on the microscopic morphology, equilibrium swelling, degradation, and mechanical properties of the films. The drug release profile exhibited a sustained release of DFO with controlled burst-lag phases resembling the Korsmeyer-Peppas pattern. The cytotoxicity and adhesion analysis using human dermal fibroblasts displays the biocompatibility of the developed PVA/EW/ND films and the formation of cellular colonies on the surface. The in vitro angiogenic capability of the developed films evaluated by the scratch wound assay and microbead-assisted tube formation study showed a significant increase in the rate of migration of human umbilical vein endothelial cells and in the number of tube-like structures. Therefore, the achieved results suggest that the presented PVA/EW/ ND film has promising potential for effective wound healing applications. Amer Chemical Soc 2022-08 Article PeerReviewed Nour, Shirin and Imani, Rana and Sharifi, Ali Mohammad (2022) Angiogenic effect of a nanoniosomal deferoxamine-loaded poly(vinyl alcohol)-Egg white film as a promising wound dressing. ACS Biomaterials Science & Engineering, 8 (8). pp. 3485-3497. ISSN 2373-9878, DOI https://doi.org/10.1021/acsbiomaterials.2c00046 <https://doi.org/10.1021/acsbiomaterials.2c00046>. 10.1021/acsbiomaterials.2c00046
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Nour, Shirin
Imani, Rana
Sharifi, Ali Mohammad
Angiogenic effect of a nanoniosomal deferoxamine-loaded poly(vinyl alcohol)-Egg white film as a promising wound dressing
description Owing to the noticeable increase in the number of patients with impaired wound healing capabilities, developing bioactive wound dressings with supportive physicomechanical and biological properties for clinical wound management has attracted much more attention nowadays. In this regard, engineered dressings with angiogenesis potential are vital for accelerated tissue regeneration. In the current study, nanoniosomal deferoxamine (DFO)-loaded transparent films of egg white-poly(vinyl alcohol) (PVA/EW/ND) were successfully fabricated at three different PVA/EW ratios (1:0, 1:1, and 1:1.5 wt/wt %) through the thin film hydration and solvent casting methods. The developed films' characterizations were carried out using scanning electron microscopy, Fourier transform infrared spectroscopy analysis, uniaxial tensile strength, water uptake, water vapor transmission rate, in vitro degradation, and drug release. The results demonstrated that the various weight ratios of PVA/EW have a significant effect on the microscopic morphology, equilibrium swelling, degradation, and mechanical properties of the films. The drug release profile exhibited a sustained release of DFO with controlled burst-lag phases resembling the Korsmeyer-Peppas pattern. The cytotoxicity and adhesion analysis using human dermal fibroblasts displays the biocompatibility of the developed PVA/EW/ND films and the formation of cellular colonies on the surface. The in vitro angiogenic capability of the developed films evaluated by the scratch wound assay and microbead-assisted tube formation study showed a significant increase in the rate of migration of human umbilical vein endothelial cells and in the number of tube-like structures. Therefore, the achieved results suggest that the presented PVA/EW/ ND film has promising potential for effective wound healing applications.
format Article
author Nour, Shirin
Imani, Rana
Sharifi, Ali Mohammad
author_facet Nour, Shirin
Imani, Rana
Sharifi, Ali Mohammad
author_sort Nour, Shirin
title Angiogenic effect of a nanoniosomal deferoxamine-loaded poly(vinyl alcohol)-Egg white film as a promising wound dressing
title_short Angiogenic effect of a nanoniosomal deferoxamine-loaded poly(vinyl alcohol)-Egg white film as a promising wound dressing
title_full Angiogenic effect of a nanoniosomal deferoxamine-loaded poly(vinyl alcohol)-Egg white film as a promising wound dressing
title_fullStr Angiogenic effect of a nanoniosomal deferoxamine-loaded poly(vinyl alcohol)-Egg white film as a promising wound dressing
title_full_unstemmed Angiogenic effect of a nanoniosomal deferoxamine-loaded poly(vinyl alcohol)-Egg white film as a promising wound dressing
title_sort angiogenic effect of a nanoniosomal deferoxamine-loaded poly(vinyl alcohol)-egg white film as a promising wound dressing
publisher Amer Chemical Soc
publishDate 2022
url http://eprints.um.edu.my/41424/
_version_ 1778161670589251584
score 13.211869

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