Staff View: Underrepresented populations in Parkinson's genetics research: Current landscape and future directions

Underrepresented populations in Parkinson's genetics research: Current landscape and future directions

Background Human genetics research lacks diversity; over 80% of genome-wide association studies have been conducted on individuals of European ancestry. In addition to limiting insights regarding disease mechanisms, disproportionate representation can create disparities preventing equitable implemen...

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Main Authors:	Schumacher-Schuh, Artur Francisco, Bieger, Andrei, Okunoye, Olaitan, Mok, Kin Ying, Lim, Shen-Yang, Bardien, Soraya, Ahmad-Annuar, Azlina, Santos-Lobato, Bruno Lopes, Strelow, Matheus Zschornack, Salama, Mohamed, Rao, Shilpa C., Zewde, Yared Zenebe, Dindayal, Saiesha, Azar, Jihan, Prashanth, Lingappa Kukkle, Rajan, Roopa, Noyce, Alastair J., Okubadejo, Njideka, Rizig, Mie, Lesage, Suzanne, Mata, Ignacio Fernandez, Progra, Global Parkinson's Genetics
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Published:	Wiley 2022
Subjects:	RC Internal medicine
Online Access:	http://eprints.um.edu.my/41414/
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spelling	my.um.eprints.414142023-11-24T01:16:45Z http://eprints.um.edu.my/41414/ Underrepresented populations in Parkinson's genetics research: Current landscape and future directions Schumacher-Schuh, Artur Francisco Bieger, Andrei Okunoye, Olaitan Mok, Kin Ying Lim, Shen-Yang Bardien, Soraya Ahmad-Annuar, Azlina Santos-Lobato, Bruno Lopes Strelow, Matheus Zschornack Salama, Mohamed Rao, Shilpa C. Zewde, Yared Zenebe Dindayal, Saiesha Azar, Jihan Prashanth, Lingappa Kukkle Rajan, Roopa Noyce, Alastair J. Okubadejo, Njideka Rizig, Mie Lesage, Suzanne Mata, Ignacio Fernandez Progra, Global Parkinson's Genetics RC Internal medicine Background Human genetics research lacks diversity; over 80% of genome-wide association studies have been conducted on individuals of European ancestry. In addition to limiting insights regarding disease mechanisms, disproportionate representation can create disparities preventing equitable implementation of personalized medicine. Objective This systematic review provides an overview of research involving Parkinson's disease (PD) genetics in underrepresented populations (URP) and sets a baseline to measure the future impact of current efforts in those populations. Methods We searched PubMed and EMBASE until October 2021 using search strings for ``PD,'' ``genetics,'' the main ``URP,'' and and the countries in Latin America, Caribbean, Africa, Asia, and Oceania (excluding Australia and New Zealand). Inclusion criteria were original studies, written in English, reporting genetic results on PD from non-European populations. Two levels of independent reviewers identified and extracted information. Results We observed imbalances in PD genetic studies among URPs. Asian participants from Greater China were described in the majority of the articles published (57%), but other populations were less well studied; for example, Blacks were represented in just 4.0% of the publications. Also, although idiopathic PD was more studied than monogenic forms of the disease, most studies analyzed a limited number of genetic variants. We identified just nine studies using a genome-wide approach published up to 2021, including URPs. Conclusion This review provides insight into the significant lack of population diversity in PD research highlighting the immediate need for better representation. The Global Parkinson's Genetics Program (GP2) and similar initiatives aim to impact research in URPs, and the early metrics presented here can be used to measure progress in the field of PD genetics in the future. (c) 2022 International Parkinson and Movement Disorder Society. Wiley 2022-08 Article PeerReviewed Schumacher-Schuh, Artur Francisco and Bieger, Andrei and Okunoye, Olaitan and Mok, Kin Ying and Lim, Shen-Yang and Bardien, Soraya and Ahmad-Annuar, Azlina and Santos-Lobato, Bruno Lopes and Strelow, Matheus Zschornack and Salama, Mohamed and Rao, Shilpa C. and Zewde, Yared Zenebe and Dindayal, Saiesha and Azar, Jihan and Prashanth, Lingappa Kukkle and Rajan, Roopa and Noyce, Alastair J. and Okubadejo, Njideka and Rizig, Mie and Lesage, Suzanne and Mata, Ignacio Fernandez and Progra, Global Parkinson's Genetics (2022) Underrepresented populations in Parkinson's genetics research: Current landscape and future directions. Movement Disorders, 37 (8). pp. 1593-1604. ISSN 0885-3185, DOI https://doi.org/10.1002/mds.29126 <https://doi.org/10.1002/mds.29126>. 10.1002/mds.29126
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	RC Internal medicine
spellingShingle	RC Internal medicine Schumacher-Schuh, Artur Francisco Bieger, Andrei Okunoye, Olaitan Mok, Kin Ying Lim, Shen-Yang Bardien, Soraya Ahmad-Annuar, Azlina Santos-Lobato, Bruno Lopes Strelow, Matheus Zschornack Salama, Mohamed Rao, Shilpa C. Zewde, Yared Zenebe Dindayal, Saiesha Azar, Jihan Prashanth, Lingappa Kukkle Rajan, Roopa Noyce, Alastair J. Okubadejo, Njideka Rizig, Mie Lesage, Suzanne Mata, Ignacio Fernandez Progra, Global Parkinson's Genetics Underrepresented populations in Parkinson's genetics research: Current landscape and future directions
description	Background Human genetics research lacks diversity; over 80% of genome-wide association studies have been conducted on individuals of European ancestry. In addition to limiting insights regarding disease mechanisms, disproportionate representation can create disparities preventing equitable implementation of personalized medicine. Objective This systematic review provides an overview of research involving Parkinson's disease (PD) genetics in underrepresented populations (URP) and sets a baseline to measure the future impact of current efforts in those populations. Methods We searched PubMed and EMBASE until October 2021 using search strings for ``PD,'' ``genetics,'' the main ``URP,'' and and the countries in Latin America, Caribbean, Africa, Asia, and Oceania (excluding Australia and New Zealand). Inclusion criteria were original studies, written in English, reporting genetic results on PD from non-European populations. Two levels of independent reviewers identified and extracted information. Results We observed imbalances in PD genetic studies among URPs. Asian participants from Greater China were described in the majority of the articles published (57%), but other populations were less well studied; for example, Blacks were represented in just 4.0% of the publications. Also, although idiopathic PD was more studied than monogenic forms of the disease, most studies analyzed a limited number of genetic variants. We identified just nine studies using a genome-wide approach published up to 2021, including URPs. Conclusion This review provides insight into the significant lack of population diversity in PD research highlighting the immediate need for better representation. The Global Parkinson's Genetics Program (GP2) and similar initiatives aim to impact research in URPs, and the early metrics presented here can be used to measure progress in the field of PD genetics in the future. (c) 2022 International Parkinson and Movement Disorder Society.
format	Article
author	Schumacher-Schuh, Artur Francisco Bieger, Andrei Okunoye, Olaitan Mok, Kin Ying Lim, Shen-Yang Bardien, Soraya Ahmad-Annuar, Azlina Santos-Lobato, Bruno Lopes Strelow, Matheus Zschornack Salama, Mohamed Rao, Shilpa C. Zewde, Yared Zenebe Dindayal, Saiesha Azar, Jihan Prashanth, Lingappa Kukkle Rajan, Roopa Noyce, Alastair J. Okubadejo, Njideka Rizig, Mie Lesage, Suzanne Mata, Ignacio Fernandez Progra, Global Parkinson's Genetics
author_facet	Schumacher-Schuh, Artur Francisco Bieger, Andrei Okunoye, Olaitan Mok, Kin Ying Lim, Shen-Yang Bardien, Soraya Ahmad-Annuar, Azlina Santos-Lobato, Bruno Lopes Strelow, Matheus Zschornack Salama, Mohamed Rao, Shilpa C. Zewde, Yared Zenebe Dindayal, Saiesha Azar, Jihan Prashanth, Lingappa Kukkle Rajan, Roopa Noyce, Alastair J. Okubadejo, Njideka Rizig, Mie Lesage, Suzanne Mata, Ignacio Fernandez Progra, Global Parkinson's Genetics
author_sort	Schumacher-Schuh, Artur Francisco
title	Underrepresented populations in Parkinson's genetics research: Current landscape and future directions
title_short	Underrepresented populations in Parkinson's genetics research: Current landscape and future directions
title_full	Underrepresented populations in Parkinson's genetics research: Current landscape and future directions
title_fullStr	Underrepresented populations in Parkinson's genetics research: Current landscape and future directions
title_full_unstemmed	Underrepresented populations in Parkinson's genetics research: Current landscape and future directions
title_sort	underrepresented populations in parkinson's genetics research: current landscape and future directions
publisher	Wiley
publishDate	2022
url	http://eprints.um.edu.my/41414/
_version_	1783876715896897536
score	13.211869

Underrepresented populations in Parkinson's genetics research: Current landscape and future directions

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