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MR imaging features of Nipah encephalitis

OBJECTIVE. The newly discovered Nipah virus causes an acute febrile encephalitic illness in humans that is associated with a high mortality. The purpose of this study is to describe the MR imaging findings of Nipah encephalitis. MATERIALS AND METHODS. MR imaging of the brain was performed in 31 p...

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Main Authors: Sarji, S.A., Abdullah, B.J., Goh, K.J., Tan, C.T., Wong, K.T.
Format: Article
Published: American Roentgen Ray Society (ARRS) 2000
Subjects:
R Medicine (General)
Online Access:http://eprints.um.edu.my/414/
https://www.ajronline.org/doi/10.2214/ajr.175.2.1750437
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spelling my.um.eprints.4142019-01-29T01:12:53Z http://eprints.um.edu.my/414/ MR imaging features of Nipah encephalitis Sarji, S.A. Abdullah, B.J. Goh, K.J. Tan, C.T. Wong, K.T. R Medicine (General) OBJECTIVE. The newly discovered Nipah virus causes an acute febrile encephalitic illness in humans that is associated with a high mortality. The purpose of this study is to describe the MR imaging findings of Nipah encephalitis. MATERIALS AND METHODS. MR imaging of the brain was performed in 31 patients with Nipah encephalitis divided into three groups. The first group (14 patients) underwent MR imaging during the acute phase of the illness and the second group (10 patients) during the later phase of the acute illness. The third group consisted of six patients who underwent MR imaging because they experienced neurologic relapse and one patient who had late-onset encephalitis. Spin-echo T1- and T2-weighted sequences and T2-weighted fluid attenuated inversion recovery (FLAIR) sequences were performed. Contrast-enhanced MR imaging was performed in four patients. RESULTS. The FLAIR sequences revealed abnormalities in all patients studied. MR imaging findings in both the acute and later phases of encephalitis were similar; the main feature of both phases was the presence of discrete high-signal-intensity lesions, measuring 2-7 mm, disseminated throughout the brain, mainly in the subcortical and deep white matter of the cerebral hemispheres. Neither mass effect nor cerebral edema was seen. There was no correlation with the focal neurologic signs, depth of coma, and outcome of the patients. The lesions were attributed to widespread microinfarctions from underlying vasculitis of cerebral small vessels. Features found on MR imaging in relapsed and late-onset encephalitis differed from the features in acute encephalitis in that confluent cortical involvement was the prominent finding in the former, as opposed to discrete focal lesions in the subcortical and deep white matter in the latter. CONCLUSION. MR imaging is a sensitive and specific diagnostic tool for evaluating Nipah encephalitis. American Roentgen Ray Society (ARRS) 2000-08 Article PeerReviewed Sarji, S.A. and Abdullah, B.J. and Goh, K.J. and Tan, C.T. and Wong, K.T. (2000) MR imaging features of Nipah encephalitis. American Journal of Roentgenology, 175 (2). pp. 437-42. ISSN 0361-803X https://www.ajronline.org/doi/10.2214/ajr.175.2.1750437 10915690
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine (General)
spellingShingle R Medicine (General)
Sarji, S.A.
Abdullah, B.J.
Goh, K.J.
Tan, C.T.
Wong, K.T.
MR imaging features of Nipah encephalitis
description OBJECTIVE. The newly discovered Nipah virus causes an acute febrile encephalitic illness in humans that is associated with a high mortality. The purpose of this study is to describe the MR imaging findings of Nipah encephalitis. MATERIALS AND METHODS. MR imaging of the brain was performed in 31 patients with Nipah encephalitis divided into three groups. The first group (14 patients) underwent MR imaging during the acute phase of the illness and the second group (10 patients) during the later phase of the acute illness. The third group consisted of six patients who underwent MR imaging because they experienced neurologic relapse and one patient who had late-onset encephalitis. Spin-echo T1- and T2-weighted sequences and T2-weighted fluid attenuated inversion recovery (FLAIR) sequences were performed. Contrast-enhanced MR imaging was performed in four patients. RESULTS. The FLAIR sequences revealed abnormalities in all patients studied. MR imaging findings in both the acute and later phases of encephalitis were similar; the main feature of both phases was the presence of discrete high-signal-intensity lesions, measuring 2-7 mm, disseminated throughout the brain, mainly in the subcortical and deep white matter of the cerebral hemispheres. Neither mass effect nor cerebral edema was seen. There was no correlation with the focal neurologic signs, depth of coma, and outcome of the patients. The lesions were attributed to widespread microinfarctions from underlying vasculitis of cerebral small vessels. Features found on MR imaging in relapsed and late-onset encephalitis differed from the features in acute encephalitis in that confluent cortical involvement was the prominent finding in the former, as opposed to discrete focal lesions in the subcortical and deep white matter in the latter. CONCLUSION. MR imaging is a sensitive and specific diagnostic tool for evaluating Nipah encephalitis.
format Article
author Sarji, S.A.
Abdullah, B.J.
Goh, K.J.
Tan, C.T.
Wong, K.T.
author_facet Sarji, S.A.
Abdullah, B.J.
Goh, K.J.
Tan, C.T.
Wong, K.T.
author_sort Sarji, S.A.
title MR imaging features of Nipah encephalitis
title_short MR imaging features of Nipah encephalitis
title_full MR imaging features of Nipah encephalitis
title_fullStr MR imaging features of Nipah encephalitis
title_full_unstemmed MR imaging features of Nipah encephalitis
title_sort mr imaging features of nipah encephalitis
publisher American Roentgen Ray Society (ARRS)
publishDate 2000
url http://eprints.um.edu.my/414/
https://www.ajronline.org/doi/10.2214/ajr.175.2.1750437
_version_ 1643686568462909440
score 13.211869

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