Cover Image

Transcorneal electrical stimulation enhances cognitive functions in aged and 5XFAD mouse models

Dementia is a major burden on global health for which there are no effective treatments. The use of noninvasive visual stimulation to ameliorate cognitive deficits is a novel concept that may be applicable for treating dementia. In this study, we investigated the effects of transcorneal electrical s...

Full description

Saved in:
Bibliographic Details
Main Authors: Yu, Wing Shan, Aquili, Luca, Wong, Kah Hui, Lo, Amy Cheuk Yin, Chan, Leanne Lai Hang, Chan, Ying-Shing, Lim, Lee Wei
Format: Article
Published: Wiley 2022
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/41238/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.um.eprints.41238
record_format eprints
spelling my.um.eprints.412382023-09-18T04:53:35Z http://eprints.um.edu.my/41238/ Transcorneal electrical stimulation enhances cognitive functions in aged and 5XFAD mouse models Yu, Wing Shan Aquili, Luca Wong, Kah Hui Lo, Amy Cheuk Yin Chan, Leanne Lai Hang Chan, Ying-Shing Lim, Lee Wei R Medicine Dementia is a major burden on global health for which there are no effective treatments. The use of noninvasive visual stimulation to ameliorate cognitive deficits is a novel concept that may be applicable for treating dementia. In this study, we investigated the effects of transcorneal electrical stimulation (TES) on memory enhancement using two mouse models, in aged mice and in the 5XFAD model of Alzheimer's disease. After 3 weeks of TES treatment, mice were subjected to Y-maze and Morris water maze tests to assess hippocampal-dependent learning and memory. Immunostaining of the hippocampus of 5XFAD mice was also performed to examine the effects of TES on amyloid plaque pathology. The results showed that TES improved the performance of both aged and 5XFAD mice in memory tests. TES also reduced hippocampal plaque deposition in male, but not female, 5XFAD mice. Moreover, TES significantly reversed the downregulated level of postsynaptic protein 95 in the hippocampus of male 5XFAD mice, suggesting the effects of TES involve a postsynaptic mechanism. Overall, these findings support further investigation of TES as a potential treatment for cognitive dysfunction and mechanistic studies of TES effects in other dementia models. Wiley 2022-09 Article PeerReviewed Yu, Wing Shan and Aquili, Luca and Wong, Kah Hui and Lo, Amy Cheuk Yin and Chan, Leanne Lai Hang and Chan, Ying-Shing and Lim, Lee Wei (2022) Transcorneal electrical stimulation enhances cognitive functions in aged and 5XFAD mouse models. Annals of The New York Academy of Sciences, 1515 (1). pp. 249-265. ISSN 0077-8923,
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Yu, Wing Shan
Aquili, Luca
Wong, Kah Hui
Lo, Amy Cheuk Yin
Chan, Leanne Lai Hang
Chan, Ying-Shing
Lim, Lee Wei
Transcorneal electrical stimulation enhances cognitive functions in aged and 5XFAD mouse models
description Dementia is a major burden on global health for which there are no effective treatments. The use of noninvasive visual stimulation to ameliorate cognitive deficits is a novel concept that may be applicable for treating dementia. In this study, we investigated the effects of transcorneal electrical stimulation (TES) on memory enhancement using two mouse models, in aged mice and in the 5XFAD model of Alzheimer's disease. After 3 weeks of TES treatment, mice were subjected to Y-maze and Morris water maze tests to assess hippocampal-dependent learning and memory. Immunostaining of the hippocampus of 5XFAD mice was also performed to examine the effects of TES on amyloid plaque pathology. The results showed that TES improved the performance of both aged and 5XFAD mice in memory tests. TES also reduced hippocampal plaque deposition in male, but not female, 5XFAD mice. Moreover, TES significantly reversed the downregulated level of postsynaptic protein 95 in the hippocampus of male 5XFAD mice, suggesting the effects of TES involve a postsynaptic mechanism. Overall, these findings support further investigation of TES as a potential treatment for cognitive dysfunction and mechanistic studies of TES effects in other dementia models.
format Article
author Yu, Wing Shan
Aquili, Luca
Wong, Kah Hui
Lo, Amy Cheuk Yin
Chan, Leanne Lai Hang
Chan, Ying-Shing
Lim, Lee Wei
author_facet Yu, Wing Shan
Aquili, Luca
Wong, Kah Hui
Lo, Amy Cheuk Yin
Chan, Leanne Lai Hang
Chan, Ying-Shing
Lim, Lee Wei
author_sort Yu, Wing Shan
title Transcorneal electrical stimulation enhances cognitive functions in aged and 5XFAD mouse models
title_short Transcorneal electrical stimulation enhances cognitive functions in aged and 5XFAD mouse models
title_full Transcorneal electrical stimulation enhances cognitive functions in aged and 5XFAD mouse models
title_fullStr Transcorneal electrical stimulation enhances cognitive functions in aged and 5XFAD mouse models
title_full_unstemmed Transcorneal electrical stimulation enhances cognitive functions in aged and 5XFAD mouse models
title_sort transcorneal electrical stimulation enhances cognitive functions in aged and 5xfad mouse models
publisher Wiley
publishDate 2022
url http://eprints.um.edu.my/41238/
_version_ 1778161645594345472
score 13.211869

Similar Items