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Role of alpha 1-blockers in the current management of hypertension

There is emerging evidence that alpha 1-blockers can be safely used in the treatment of hypertension. These drugs can be used in almost all hypertensive patients for blood pressure control. However, there are several special indications. Benign prostatic hyperplasia is a compelling indication of alp...

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Main Authors: Li, Hua, Xu, Ting-Yan, Li, Yan, Chia, Yook-Chin, Buranakitjaroen, Peera, Cheng, Hao-Min, Van Huynh, Minh, Sogunuru, Guru Prasad, Tay, Jam Chin, Wang, Tzung-Dau, Kario, Kazuomi, Wang, Ji-Guang
Format: Article
Published: Wiley 2022
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R Medicine
Online Access:http://eprints.um.edu.my/41140/
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spelling my.um.eprints.411402023-09-07T07:57:37Z http://eprints.um.edu.my/41140/ Role of alpha 1-blockers in the current management of hypertension Li, Hua Xu, Ting-Yan Li, Yan Chia, Yook-Chin Buranakitjaroen, Peera Cheng, Hao-Min Van Huynh, Minh Sogunuru, Guru Prasad Tay, Jam Chin Wang, Tzung-Dau Kario, Kazuomi Wang, Ji-Guang R Medicine There is emerging evidence that alpha 1-blockers can be safely used in the treatment of hypertension. These drugs can be used in almost all hypertensive patients for blood pressure control. However, there are several special indications. Benign prostatic hyperplasia is a compelling indication of alpha 1-blockers, because of the dual treatment effect on both high blood pressure and lower urinary tract symptoms. Many patients with resistant hypertension would require alpha 1-blockers as add-on therapy. Primary aldosteronism screen is a rapidly increasing clinical demand in the management of hypertension, where alpha 1-blockers are useful for blood pressure control in the preparation for the measurement of plasma aldosterone and renin. Nonetheless, alpha 1-blockers have to be used under several considerations. Among the currently available agents, only long-acting alpha 1-blockers, such as doxazosin gastrointestinal therapeutic system 4-8 mg daily and terazosin 2-4 mg daily, should be chosen. Orthostatic hypotension is a concern with the use of alpha 1-blockers especially in the elderly, and requires careful initial bedtime dosing and avoiding overdosing. Fluid retention is potentially also a concern, which may be overcome by combining an alpha 1-blocker with a diuretic. Wiley 2022-09 Article PeerReviewed Li, Hua and Xu, Ting-Yan and Li, Yan and Chia, Yook-Chin and Buranakitjaroen, Peera and Cheng, Hao-Min and Van Huynh, Minh and Sogunuru, Guru Prasad and Tay, Jam Chin and Wang, Tzung-Dau and Kario, Kazuomi and Wang, Ji-Guang (2022) Role of alpha 1-blockers in the current management of hypertension. Journal of Clinical Hypertension, 24 (9, SI). pp. 1180-1186. ISSN 1524-6175, DOI https://doi.org/10.1111/jch.14556 <https://doi.org/10.1111/jch.14556>. 10.1111/jch.14556
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Li, Hua
Xu, Ting-Yan
Li, Yan
Chia, Yook-Chin
Buranakitjaroen, Peera
Cheng, Hao-Min
Van Huynh, Minh
Sogunuru, Guru Prasad
Tay, Jam Chin
Wang, Tzung-Dau
Kario, Kazuomi
Wang, Ji-Guang
Role of alpha 1-blockers in the current management of hypertension
description There is emerging evidence that alpha 1-blockers can be safely used in the treatment of hypertension. These drugs can be used in almost all hypertensive patients for blood pressure control. However, there are several special indications. Benign prostatic hyperplasia is a compelling indication of alpha 1-blockers, because of the dual treatment effect on both high blood pressure and lower urinary tract symptoms. Many patients with resistant hypertension would require alpha 1-blockers as add-on therapy. Primary aldosteronism screen is a rapidly increasing clinical demand in the management of hypertension, where alpha 1-blockers are useful for blood pressure control in the preparation for the measurement of plasma aldosterone and renin. Nonetheless, alpha 1-blockers have to be used under several considerations. Among the currently available agents, only long-acting alpha 1-blockers, such as doxazosin gastrointestinal therapeutic system 4-8 mg daily and terazosin 2-4 mg daily, should be chosen. Orthostatic hypotension is a concern with the use of alpha 1-blockers especially in the elderly, and requires careful initial bedtime dosing and avoiding overdosing. Fluid retention is potentially also a concern, which may be overcome by combining an alpha 1-blocker with a diuretic.
format Article
author Li, Hua
Xu, Ting-Yan
Li, Yan
Chia, Yook-Chin
Buranakitjaroen, Peera
Cheng, Hao-Min
Van Huynh, Minh
Sogunuru, Guru Prasad
Tay, Jam Chin
Wang, Tzung-Dau
Kario, Kazuomi
Wang, Ji-Guang
author_facet Li, Hua
Xu, Ting-Yan
Li, Yan
Chia, Yook-Chin
Buranakitjaroen, Peera
Cheng, Hao-Min
Van Huynh, Minh
Sogunuru, Guru Prasad
Tay, Jam Chin
Wang, Tzung-Dau
Kario, Kazuomi
Wang, Ji-Guang
author_sort Li, Hua
title Role of alpha 1-blockers in the current management of hypertension
title_short Role of alpha 1-blockers in the current management of hypertension
title_full Role of alpha 1-blockers in the current management of hypertension
title_fullStr Role of alpha 1-blockers in the current management of hypertension
title_full_unstemmed Role of alpha 1-blockers in the current management of hypertension
title_sort role of alpha 1-blockers in the current management of hypertension
publisher Wiley
publishDate 2022
url http://eprints.um.edu.my/41140/
_version_ 1778161631166988288
score 13.211869

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