Staff View: Who should be screened for primary aldosteronism? A comprehensive review of current evidence

Who should be screened for primary aldosteronism? A comprehensive review of current evidence

Arterial hypertension is a major risk factor for cardiovascular disease. The prevalence of primary aldosteronism (PA) ranges from 5% to 10% in the general hypertensive population and is regarded as one of the most common causes of secondary hypertension. There are two major causes of PA: bilateral a...

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Main Authors:	Huang, Wei-Chieh, Lin, Yen-Hung, Wu, Vin-Cent, Chen, Chen-Huan, Siddique, Saulat, Chia, Yook-Chin, Tay, Jam Chin, Sogunuru, Guruprasad, Cheng, Hao-Min, Kario, Kazuomi
Format:	Article
Published:	Wiley 2022
Subjects:	R Medicine
Online Access:	http://eprints.um.edu.my/41134/
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spelling	my.um.eprints.411342023-09-07T07:12:41Z http://eprints.um.edu.my/41134/ Who should be screened for primary aldosteronism? A comprehensive review of current evidence Huang, Wei-Chieh Lin, Yen-Hung Wu, Vin-Cent Chen, Chen-Huan Siddique, Saulat Chia, Yook-Chin Tay, Jam Chin Sogunuru, Guruprasad Cheng, Hao-Min Kario, Kazuomi R Medicine Arterial hypertension is a major risk factor for cardiovascular disease. The prevalence of primary aldosteronism (PA) ranges from 5% to 10% in the general hypertensive population and is regarded as one of the most common causes of secondary hypertension. There are two major causes of PA: bilateral adrenal hyperplasia and aldosterone-producing adenoma. The diagnosis of PA comprises screening, confirmatory testing, and subtype differentiation. The Endocrine Society Practice Guidelines for the diagnosis and treatment of PA recommends screening of patients at an increased risk of PA. These categories include patients with stage 2 and 3 hypertension, drug-resistant hypertension, hypertensive with spontaneous or diuretic-induced hypokalemia, hypertension with adrenal incidentaloma, hypertensive with a family history of early onset hypertension or cerebrovascular accident at a young age, and all hypertensive first-degree relatives of patients with PA. Recently, several studies have linked PA with obstructive sleep apnea and atrial fibrillation unexplained by structural heart defects and/or other conditions known to cause the arrhythmia, which may be partly responsible for the higher rates of cardiovascular and cerebrovascular accidents in patients with PA. The aim of this review is to discuss which patients should be screened for PA, focusing not only on well-established guidelines but also on additional groups of patients with a potentially higher prevalence of PA, as has been reported in recent research. Wiley 2022-09 Article PeerReviewed Huang, Wei-Chieh and Lin, Yen-Hung and Wu, Vin-Cent and Chen, Chen-Huan and Siddique, Saulat and Chia, Yook-Chin and Tay, Jam Chin and Sogunuru, Guruprasad and Cheng, Hao-Min and Kario, Kazuomi (2022) Who should be screened for primary aldosteronism? A comprehensive review of current evidence. Journal of Clinical Hypertension, 24 (9, SI). pp. 1194-1203. ISSN 1524-6175, DOI https://doi.org/10.1111/jch.14558 <https://doi.org/10.1111/jch.14558>. 10.1111/jch.14558
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	R Medicine
spellingShingle	R Medicine Huang, Wei-Chieh Lin, Yen-Hung Wu, Vin-Cent Chen, Chen-Huan Siddique, Saulat Chia, Yook-Chin Tay, Jam Chin Sogunuru, Guruprasad Cheng, Hao-Min Kario, Kazuomi Who should be screened for primary aldosteronism? A comprehensive review of current evidence
description	Arterial hypertension is a major risk factor for cardiovascular disease. The prevalence of primary aldosteronism (PA) ranges from 5% to 10% in the general hypertensive population and is regarded as one of the most common causes of secondary hypertension. There are two major causes of PA: bilateral adrenal hyperplasia and aldosterone-producing adenoma. The diagnosis of PA comprises screening, confirmatory testing, and subtype differentiation. The Endocrine Society Practice Guidelines for the diagnosis and treatment of PA recommends screening of patients at an increased risk of PA. These categories include patients with stage 2 and 3 hypertension, drug-resistant hypertension, hypertensive with spontaneous or diuretic-induced hypokalemia, hypertension with adrenal incidentaloma, hypertensive with a family history of early onset hypertension or cerebrovascular accident at a young age, and all hypertensive first-degree relatives of patients with PA. Recently, several studies have linked PA with obstructive sleep apnea and atrial fibrillation unexplained by structural heart defects and/or other conditions known to cause the arrhythmia, which may be partly responsible for the higher rates of cardiovascular and cerebrovascular accidents in patients with PA. The aim of this review is to discuss which patients should be screened for PA, focusing not only on well-established guidelines but also on additional groups of patients with a potentially higher prevalence of PA, as has been reported in recent research.
format	Article
author	Huang, Wei-Chieh Lin, Yen-Hung Wu, Vin-Cent Chen, Chen-Huan Siddique, Saulat Chia, Yook-Chin Tay, Jam Chin Sogunuru, Guruprasad Cheng, Hao-Min Kario, Kazuomi
author_facet	Huang, Wei-Chieh Lin, Yen-Hung Wu, Vin-Cent Chen, Chen-Huan Siddique, Saulat Chia, Yook-Chin Tay, Jam Chin Sogunuru, Guruprasad Cheng, Hao-Min Kario, Kazuomi
author_sort	Huang, Wei-Chieh
title	Who should be screened for primary aldosteronism? A comprehensive review of current evidence
title_short	Who should be screened for primary aldosteronism? A comprehensive review of current evidence
title_full	Who should be screened for primary aldosteronism? A comprehensive review of current evidence
title_fullStr	Who should be screened for primary aldosteronism? A comprehensive review of current evidence
title_full_unstemmed	Who should be screened for primary aldosteronism? A comprehensive review of current evidence
title_sort	who should be screened for primary aldosteronism? a comprehensive review of current evidence
publisher	Wiley
publishDate	2022
url	http://eprints.um.edu.my/41134/
_version_	1778161630253678592
score	13.211869

Who should be screened for primary aldosteronism? A comprehensive review of current evidence

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