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Toxoplasmosis: a silent opportunistic diseases in HIV/AIDS patients

A total of 693 HIV/AIDS patients were recruited in this retrospective and descriptive study during April 2003 to December 2004, Hospital Kuala Lumpur, Malaysia. It was found that both genders were shown to be within the same range of age (M = 18-79 vs F = 18-73), while a median age was slightly high...

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Main Authors:	Sim, B.L.H., Khairul Anuar, A., Nissapatorn, V., Lee, C.K.C., Lim, Y.A.L., Tan, K.S., Jamaiah, I., Rohela, M., Ahmad, A., Hadita, S., Lott, P.W., Ng, K.T., Zuliana, J., Poh, M.E.
Format:	Article
Language:	English
Published:	2007
Subjects:	R Medicine
Online Access:	http://eprints.um.edu.my/4098/1/Toxoplasmosis-_A_Silent_opportunistic_diseases_in_HIV_or_AIDS_patients.pdf http://eprints.um.edu.my/4098/ http://scialert.net/qredirect.php?doi=jp.2007.23.31&linkid=pdf
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spelling	my.um.eprints.40982014-12-30T02:38:24Z http://eprints.um.edu.my/4098/ Toxoplasmosis: a silent opportunistic diseases in HIV/AIDS patients Sim, B.L.H. Khairul Anuar, A. Nissapatorn, V. Lee, C.K.C. Lim, Y.A.L. Tan, K.S. Jamaiah, I. Rohela, M. Ahmad, A. Hadita, S. Lott, P.W. Ng, K.T. Zuliana, J. Poh, M.E. R Medicine A total of 693 HIV/AIDS patients were recruited in this retrospective and descriptive study during April 2003 to December 2004, Hospital Kuala Lumpur, Malaysia. It was found that both genders were shown to be within the same range of age (M = 18-79 vs F = 18-73), while a median age was slightly higher in male (36 years) than female (31 years). The majority of both genders were significantly shown in the age group of 25 to 34 years, but a higher rate was evident in females (42) (p = 0.001). It was even observed that male patients were mainly Chinese (44.7) and single (57.3) (p = 0.001), while the females were Chinese (40.6) and married (83.3) (p = 0.000). However, the highest numbers of both genders were manifested to be heterosexuals (M = 47.6 vs F = 86.2), followed by intravenous drug users (M = 39.3 vs F = 6.5) (p = 0.000). The range of CD4 cell count was 0 to 1799 with a median of 230 cells/mm3. The level of CD4 cell count of < 200 cells/mm3 was significantly found in males (48.5) and between 200 to 499 and â�¥500 cells/mm3 were 36.2 and 26.8 in females, respectively (p = 0.001). Overall, the Toxoplasma seroprevalence was 43.85 where seropositive of anti-Toxoplasma antibody relatively higher in males (50) than in females (37.7) (p = 0.015). Toxoplasma seropositivity was thoroughly evident among Malays (168; 51.1), Intravenous Drug Users (IDUs) and patients with toxoplasmic encephalitis (TE) (p = 0.001). Furthermore, anti-retroviral therapy including HAART was more significantly found in patients with 9 seropositive Toxoplasma when compared to 2 seronegative and unknown serostatus patients (p = 0.025). Seventeen AIDS-related toxoplasmic encephalitis patients were diagnosed at the time of this study, depicting hemiparesis as the most common neurological manifestation in 11 (64.7) patients, followed by headache and seizure in 6 (35.3) and 3 (17.7) patients, respectively. Interestingly, CT scan finding showed mass like structure with multiple (58.8), ring enhancing lesions (100), in parietal region (58.8) and edema (29.4) in these patients. Overall, the treatment outcome showed that 13 (76.5) patients had completed treatment with maintenance, whereas, 3 (17.6) patients were lost to follow up and 1 (6) patient was transferred to another hospital. No relapse or death case was reported during the time of this study. 2007 Article PeerReviewed application/pdf en http://eprints.um.edu.my/4098/1/Toxoplasmosis-_A_Silent_opportunistic_diseases_in_HIV_or_AIDS_patients.pdf Sim, B.L.H. and Khairul Anuar, A. and Nissapatorn, V. and Lee, C.K.C. and Lim, Y.A.L. and Tan, K.S. and Jamaiah, I. and Rohela, M. and Ahmad, A. and Hadita, S. and Lott, P.W. and Ng, K.T. and Zuliana, J. and Poh, M.E. (2007) Toxoplasmosis: a silent opportunistic diseases in HIV/AIDS patients. Research Journal of Parasitology, 2 (1). pp. 23-31. ISSN 1816-4943 http://scialert.net/qredirect.php?doi=jp.2007.23.31&linkid=pdf
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
language	English
topic	R Medicine
spellingShingle	R Medicine Sim, B.L.H. Khairul Anuar, A. Nissapatorn, V. Lee, C.K.C. Lim, Y.A.L. Tan, K.S. Jamaiah, I. Rohela, M. Ahmad, A. Hadita, S. Lott, P.W. Ng, K.T. Zuliana, J. Poh, M.E. Toxoplasmosis: a silent opportunistic diseases in HIV/AIDS patients
description	A total of 693 HIV/AIDS patients were recruited in this retrospective and descriptive study during April 2003 to December 2004, Hospital Kuala Lumpur, Malaysia. It was found that both genders were shown to be within the same range of age (M = 18-79 vs F = 18-73), while a median age was slightly higher in male (36 years) than female (31 years). The majority of both genders were significantly shown in the age group of 25 to 34 years, but a higher rate was evident in females (42) (p = 0.001). It was even observed that male patients were mainly Chinese (44.7) and single (57.3) (p = 0.001), while the females were Chinese (40.6) and married (83.3) (p = 0.000). However, the highest numbers of both genders were manifested to be heterosexuals (M = 47.6 vs F = 86.2), followed by intravenous drug users (M = 39.3 vs F = 6.5) (p = 0.000). The range of CD4 cell count was 0 to 1799 with a median of 230 cells/mm3. The level of CD4 cell count of < 200 cells/mm3 was significantly found in males (48.5) and between 200 to 499 and â�¥500 cells/mm3 were 36.2 and 26.8 in females, respectively (p = 0.001). Overall, the Toxoplasma seroprevalence was 43.85 where seropositive of anti-Toxoplasma antibody relatively higher in males (50) than in females (37.7) (p = 0.015). Toxoplasma seropositivity was thoroughly evident among Malays (168; 51.1), Intravenous Drug Users (IDUs) and patients with toxoplasmic encephalitis (TE) (p = 0.001). Furthermore, anti-retroviral therapy including HAART was more significantly found in patients with 9 seropositive Toxoplasma when compared to 2 seronegative and unknown serostatus patients (p = 0.025). Seventeen AIDS-related toxoplasmic encephalitis patients were diagnosed at the time of this study, depicting hemiparesis as the most common neurological manifestation in 11 (64.7) patients, followed by headache and seizure in 6 (35.3) and 3 (17.7) patients, respectively. Interestingly, CT scan finding showed mass like structure with multiple (58.8), ring enhancing lesions (100), in parietal region (58.8) and edema (29.4) in these patients. Overall, the treatment outcome showed that 13 (76.5) patients had completed treatment with maintenance, whereas, 3 (17.6) patients were lost to follow up and 1 (6) patient was transferred to another hospital. No relapse or death case was reported during the time of this study.
format	Article
author	Sim, B.L.H. Khairul Anuar, A. Nissapatorn, V. Lee, C.K.C. Lim, Y.A.L. Tan, K.S. Jamaiah, I. Rohela, M. Ahmad, A. Hadita, S. Lott, P.W. Ng, K.T. Zuliana, J. Poh, M.E.
author_facet	Sim, B.L.H. Khairul Anuar, A. Nissapatorn, V. Lee, C.K.C. Lim, Y.A.L. Tan, K.S. Jamaiah, I. Rohela, M. Ahmad, A. Hadita, S. Lott, P.W. Ng, K.T. Zuliana, J. Poh, M.E.
author_sort	Sim, B.L.H.
title	Toxoplasmosis: a silent opportunistic diseases in HIV/AIDS patients
title_short	Toxoplasmosis: a silent opportunistic diseases in HIV/AIDS patients
title_full	Toxoplasmosis: a silent opportunistic diseases in HIV/AIDS patients
title_fullStr	Toxoplasmosis: a silent opportunistic diseases in HIV/AIDS patients
title_full_unstemmed	Toxoplasmosis: a silent opportunistic diseases in HIV/AIDS patients
title_sort	toxoplasmosis: a silent opportunistic diseases in hiv/aids patients
publishDate	2007
url	http://eprints.um.edu.my/4098/1/Toxoplasmosis-_A_Silent_opportunistic_diseases_in_HIV_or_AIDS_patients.pdf http://eprints.um.edu.my/4098/ http://scialert.net/qredirect.php?doi=jp.2007.23.31&linkid=pdf
_version_	1643687260929916928
score	13.211869

Toxoplasmosis: a silent opportunistic diseases in HIV/AIDS patients

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