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Quality of life in Malaysian children with inflammatory bowel disease: An understudied population

Aim Quality of life (QoL) in children with inflammatory bowel disease (IBD) is often impaired by underlying disease. We evaluated factors affecting health-related QoL (HRQoL) in Malaysian children with IBD. Methods A cross-sectional study using IMPACT-III questionnaires evaluating HRQoL in children...

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Main Authors:	Lee, Gin W., Chew, Kee S., Wong, Sean Y., Chong, Sze Y., Ong, Sik Y., Lee, Way Seah
Format:	Article
Published:	Wiley 2022
Subjects:	R Medicine RJ Pediatrics
Online Access:	http://eprints.um.edu.my/40937/
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spelling	my.um.eprints.409372023-08-25T08:04:05Z http://eprints.um.edu.my/40937/ Quality of life in Malaysian children with inflammatory bowel disease: An understudied population Lee, Gin W. Chew, Kee S. Wong, Sean Y. Chong, Sze Y. Ong, Sik Y. Lee, Way Seah R Medicine RJ Pediatrics Aim Quality of life (QoL) in children with inflammatory bowel disease (IBD) is often impaired by underlying disease. We evaluated factors affecting health-related QoL (HRQoL) in Malaysian children with IBD. Methods A cross-sectional study using IMPACT-III questionnaires evaluating HRQoL in children aged 8-17 years with duration of IBD of >= 6 months was conducted. IMPACT-III, a validated instrument designed to measure HRQoL in children with IBD, was used. Higher IMPACT-III (maximum = 100) score indicates better HRQoL. Impact of socio-demographic and clinical factors of IBD on the HRQoL was evaluated. Paediatric Crohn's disease (CD) and ulcerative colitis (UC) activity indices were used to classify disease severity. Results A total of 75 children (UC = 44, CD = 41; mean (SD) age at diagnosis 8.2 (3.5) years) were interviewed at mean age of 12.8 (2.7) years. Mean IMPACT-III score was significantly lower in children with more severe disease (mild: 71.8 (13.6) vs. moderate: 65.5 (10.9) vs. severe: 46.3 (14.5); P < 0.001), history of hospitalisation (yes: 64.0 (14.0) vs. none: 74.1 (12.2), P = 0.034) and a higher number of admissions (r = -0.352, P = 0.041) in preceding 6 months. Diagnosis at a younger age (r = -0.31, P = 0.007) and a longer duration of disease (r = 0.286, P = 0.013) was associated with higher score. A higher weight-for-age (r = 0.261, P = 0.023) or body mass index-for-age z-score (r = 0.235, P = 0.042) was correlated with a better body image domain score, respectively. Conclusions In Malaysian children with IBD, HRQoL was adversely affected by a more severe disease. Better control of disease activity and maintaining long-term remission are important to improve the HRQoL in childhood IBD. Wiley 2022-11 Article PeerReviewed Lee, Gin W. and Chew, Kee S. and Wong, Sean Y. and Chong, Sze Y. and Ong, Sik Y. and Lee, Way Seah (2022) Quality of life in Malaysian children with inflammatory bowel disease: An understudied population. Journal of Paediatrics and Child Health, 58 (11). pp. 1972-1979. ISSN 1034-4810, DOI https://doi.org/10.1111/jpc.16130 <https://doi.org/10.1111/jpc.16130>. 10.1111/jpc.16130
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	R Medicine RJ Pediatrics
spellingShingle	R Medicine RJ Pediatrics Lee, Gin W. Chew, Kee S. Wong, Sean Y. Chong, Sze Y. Ong, Sik Y. Lee, Way Seah Quality of life in Malaysian children with inflammatory bowel disease: An understudied population
description	Aim Quality of life (QoL) in children with inflammatory bowel disease (IBD) is often impaired by underlying disease. We evaluated factors affecting health-related QoL (HRQoL) in Malaysian children with IBD. Methods A cross-sectional study using IMPACT-III questionnaires evaluating HRQoL in children aged 8-17 years with duration of IBD of >= 6 months was conducted. IMPACT-III, a validated instrument designed to measure HRQoL in children with IBD, was used. Higher IMPACT-III (maximum = 100) score indicates better HRQoL. Impact of socio-demographic and clinical factors of IBD on the HRQoL was evaluated. Paediatric Crohn's disease (CD) and ulcerative colitis (UC) activity indices were used to classify disease severity. Results A total of 75 children (UC = 44, CD = 41; mean (SD) age at diagnosis 8.2 (3.5) years) were interviewed at mean age of 12.8 (2.7) years. Mean IMPACT-III score was significantly lower in children with more severe disease (mild: 71.8 (13.6) vs. moderate: 65.5 (10.9) vs. severe: 46.3 (14.5); P < 0.001), history of hospitalisation (yes: 64.0 (14.0) vs. none: 74.1 (12.2), P = 0.034) and a higher number of admissions (r = -0.352, P = 0.041) in preceding 6 months. Diagnosis at a younger age (r = -0.31, P = 0.007) and a longer duration of disease (r = 0.286, P = 0.013) was associated with higher score. A higher weight-for-age (r = 0.261, P = 0.023) or body mass index-for-age z-score (r = 0.235, P = 0.042) was correlated with a better body image domain score, respectively. Conclusions In Malaysian children with IBD, HRQoL was adversely affected by a more severe disease. Better control of disease activity and maintaining long-term remission are important to improve the HRQoL in childhood IBD.
format	Article
author	Lee, Gin W. Chew, Kee S. Wong, Sean Y. Chong, Sze Y. Ong, Sik Y. Lee, Way Seah
author_facet	Lee, Gin W. Chew, Kee S. Wong, Sean Y. Chong, Sze Y. Ong, Sik Y. Lee, Way Seah
author_sort	Lee, Gin W.
title	Quality of life in Malaysian children with inflammatory bowel disease: An understudied population
title_short	Quality of life in Malaysian children with inflammatory bowel disease: An understudied population
title_full	Quality of life in Malaysian children with inflammatory bowel disease: An understudied population
title_fullStr	Quality of life in Malaysian children with inflammatory bowel disease: An understudied population
title_full_unstemmed	Quality of life in Malaysian children with inflammatory bowel disease: An understudied population
title_sort	quality of life in malaysian children with inflammatory bowel disease: an understudied population
publisher	Wiley
publishDate	2022
url	http://eprints.um.edu.my/40937/
_version_	1776247420502409216
score	13.211869

Quality of life in Malaysian children with inflammatory bowel disease: An understudied population

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