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Retrograde axonal transport of poliovirus and EV71 in motor neurons

Poliovirus (PV) can spread through neural pathway to the central nervous system and replicates in motor neurons, which leads to poliomyelitis. Enterovirus 71 (EV71), which is closely related to PV, is one of the causative agents of hand-foot-and-mouth disease and can cause severe neurological diseas...

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Main Authors: Ohka, Seii, Tan, Soon Hao, Kaneda, Shohei, Fujii, Teruo, Schiavo, Giampietro
Format: Article
Published: Academic Press 2022
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/40922/
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spelling my.um.eprints.409222023-08-25T03:52:39Z http://eprints.um.edu.my/40922/ Retrograde axonal transport of poliovirus and EV71 in motor neurons Ohka, Seii Tan, Soon Hao Kaneda, Shohei Fujii, Teruo Schiavo, Giampietro R Medicine Poliovirus (PV) can spread through neural pathway to the central nervous system and replicates in motor neurons, which leads to poliomyelitis. Enterovirus 71 (EV71), which is closely related to PV, is one of the causative agents of hand-foot-and-mouth disease and can cause severe neurological diseases similar to poliomyelitis. Since PV is similar to EV71 in its motor neurotoxicity, we tried to understand if the results obtained with PV are of general applicability to EV71 and other viruses with similar characteristics. Using microfluidic devices, we demonstrated that both PV capsid and the PV genome undergo axonal retro-grade transport with human PV receptor (hPVR), and the transported virus replicated in the soma of hPVR-expressing motor neurons. Similar to PV in hPVR-transgenic (Tg) mice, neural pathway ensuring spreading of EV71 has been shown in adult human scavenger receptor class B, member 2 (hSCARB2)-Tg mice. We have validated this finding in microfluidic devices by showing that EV71 is retrogradely transported together with hSCARB2 to the cell body where it replicates in an hSCARB2-dependent manner.(c) 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Academic Press 2022-10 Article PeerReviewed Ohka, Seii and Tan, Soon Hao and Kaneda, Shohei and Fujii, Teruo and Schiavo, Giampietro (2022) Retrograde axonal transport of poliovirus and EV71 in motor neurons. Biochemical and Biophysical Research Communications, 626. pp. 72-78. ISSN 0006-291X, DOI https://doi.org/10.1016/j.bbrc.2022.08.015 <https://doi.org/10.1016/j.bbrc.2022.08.015>. 10.1016/j.bbrc.2022.08.015
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Ohka, Seii
Tan, Soon Hao
Kaneda, Shohei
Fujii, Teruo
Schiavo, Giampietro
Retrograde axonal transport of poliovirus and EV71 in motor neurons
description Poliovirus (PV) can spread through neural pathway to the central nervous system and replicates in motor neurons, which leads to poliomyelitis. Enterovirus 71 (EV71), which is closely related to PV, is one of the causative agents of hand-foot-and-mouth disease and can cause severe neurological diseases similar to poliomyelitis. Since PV is similar to EV71 in its motor neurotoxicity, we tried to understand if the results obtained with PV are of general applicability to EV71 and other viruses with similar characteristics. Using microfluidic devices, we demonstrated that both PV capsid and the PV genome undergo axonal retro-grade transport with human PV receptor (hPVR), and the transported virus replicated in the soma of hPVR-expressing motor neurons. Similar to PV in hPVR-transgenic (Tg) mice, neural pathway ensuring spreading of EV71 has been shown in adult human scavenger receptor class B, member 2 (hSCARB2)-Tg mice. We have validated this finding in microfluidic devices by showing that EV71 is retrogradely transported together with hSCARB2 to the cell body where it replicates in an hSCARB2-dependent manner.(c) 2022 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
format Article
author Ohka, Seii
Tan, Soon Hao
Kaneda, Shohei
Fujii, Teruo
Schiavo, Giampietro
author_facet Ohka, Seii
Tan, Soon Hao
Kaneda, Shohei
Fujii, Teruo
Schiavo, Giampietro
author_sort Ohka, Seii
title Retrograde axonal transport of poliovirus and EV71 in motor neurons
title_short Retrograde axonal transport of poliovirus and EV71 in motor neurons
title_full Retrograde axonal transport of poliovirus and EV71 in motor neurons
title_fullStr Retrograde axonal transport of poliovirus and EV71 in motor neurons
title_full_unstemmed Retrograde axonal transport of poliovirus and EV71 in motor neurons
title_sort retrograde axonal transport of poliovirus and ev71 in motor neurons
publisher Academic Press
publishDate 2022
url http://eprints.um.edu.my/40922/
_version_ 1775622730583900160
score 13.211869

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