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CYP35 family in Caenorhabditis elegans biological processes: Fatty acid synthesis, xenobiotic metabolism, and stress responses

With more than 80 cytochrome P450 (CYP) encoding genes found in the nematode Caenorhabditis elegans (C. elegans), the cyp35 genes are one of the important genes involved in many biological processes such as fatty acid synthesis and storage, xenobiotic stress response, dauer and eggshell formation, a...

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Main Authors: Lim, Sharoen Yu Ming, Alshagga, Mustafa, Kong, Cin, Alshawsh, Mohammed Abdullah, Alshehade, Salah AbdulRazak, Pan, Yan
Format: Article
Published: Springer Heidelberg 2022
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/40883/
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spelling my.um.eprints.408832023-09-25T07:30:41Z http://eprints.um.edu.my/40883/ CYP35 family in Caenorhabditis elegans biological processes: Fatty acid synthesis, xenobiotic metabolism, and stress responses Lim, Sharoen Yu Ming Alshagga, Mustafa Kong, Cin Alshawsh, Mohammed Abdullah Alshehade, Salah AbdulRazak Pan, Yan R Medicine With more than 80 cytochrome P450 (CYP) encoding genes found in the nematode Caenorhabditis elegans (C. elegans), the cyp35 genes are one of the important genes involved in many biological processes such as fatty acid synthesis and storage, xenobiotic stress response, dauer and eggshell formation, and xenobiotic metabolism. The C. elegans CYP35 subfamily consisted of A, B, C, and D, which have the closest homolog to human CYP2 family. C. elegans homologs could answer part of the hunt for human disease genes. This review aims to provide an overview of CYP35 in C. elegans and their human homologs, to explore the roles of CYP35 in various C. elegans biological processes, and how the genes of cyp35 upregulation or downregulation are influenced by biological processes, upon exposure to xenobiotics or changes in diet and environment. The C. elegans CYP35 gene expression could be upregulated by heavy metals, pesticides, anti-parasitic and anti-chemotherapeutic agents, polycyclic aromatic hydrocarbons (PAHs), nanoparticles, drugs, and organic chemical compounds. Among the cyp35 genes, cyp-35A2 is involved in most of the C. elegans biological processes regulation. Further venture of cyp35 genes, the closest homolog of CYP2 which is the largest family of human CYPs, may have the power to locate cyps gene targets, discovery of novel therapeutic strategies, and possibly a successful medical regime to combat obesity, cancers, and cyps gene-related diseases. Springer Heidelberg 2022-12 Article PeerReviewed Lim, Sharoen Yu Ming and Alshagga, Mustafa and Kong, Cin and Alshawsh, Mohammed Abdullah and Alshehade, Salah AbdulRazak and Pan, Yan (2022) CYP35 family in Caenorhabditis elegans biological processes: Fatty acid synthesis, xenobiotic metabolism, and stress responses. Archives of Toxicology, 96 (12). pp. 3163-3174. ISSN 0340-5761, DOI https://doi.org/10.1007/s00204-022-03382-3 <https://doi.org/10.1007/s00204-022-03382-3>. 10.1007/s00204-022-03382-3
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Lim, Sharoen Yu Ming
Alshagga, Mustafa
Kong, Cin
Alshawsh, Mohammed Abdullah
Alshehade, Salah AbdulRazak
Pan, Yan
CYP35 family in Caenorhabditis elegans biological processes: Fatty acid synthesis, xenobiotic metabolism, and stress responses
description With more than 80 cytochrome P450 (CYP) encoding genes found in the nematode Caenorhabditis elegans (C. elegans), the cyp35 genes are one of the important genes involved in many biological processes such as fatty acid synthesis and storage, xenobiotic stress response, dauer and eggshell formation, and xenobiotic metabolism. The C. elegans CYP35 subfamily consisted of A, B, C, and D, which have the closest homolog to human CYP2 family. C. elegans homologs could answer part of the hunt for human disease genes. This review aims to provide an overview of CYP35 in C. elegans and their human homologs, to explore the roles of CYP35 in various C. elegans biological processes, and how the genes of cyp35 upregulation or downregulation are influenced by biological processes, upon exposure to xenobiotics or changes in diet and environment. The C. elegans CYP35 gene expression could be upregulated by heavy metals, pesticides, anti-parasitic and anti-chemotherapeutic agents, polycyclic aromatic hydrocarbons (PAHs), nanoparticles, drugs, and organic chemical compounds. Among the cyp35 genes, cyp-35A2 is involved in most of the C. elegans biological processes regulation. Further venture of cyp35 genes, the closest homolog of CYP2 which is the largest family of human CYPs, may have the power to locate cyps gene targets, discovery of novel therapeutic strategies, and possibly a successful medical regime to combat obesity, cancers, and cyps gene-related diseases.
format Article
author Lim, Sharoen Yu Ming
Alshagga, Mustafa
Kong, Cin
Alshawsh, Mohammed Abdullah
Alshehade, Salah AbdulRazak
Pan, Yan
author_facet Lim, Sharoen Yu Ming
Alshagga, Mustafa
Kong, Cin
Alshawsh, Mohammed Abdullah
Alshehade, Salah AbdulRazak
Pan, Yan
author_sort Lim, Sharoen Yu Ming
title CYP35 family in Caenorhabditis elegans biological processes: Fatty acid synthesis, xenobiotic metabolism, and stress responses
title_short CYP35 family in Caenorhabditis elegans biological processes: Fatty acid synthesis, xenobiotic metabolism, and stress responses
title_full CYP35 family in Caenorhabditis elegans biological processes: Fatty acid synthesis, xenobiotic metabolism, and stress responses
title_fullStr CYP35 family in Caenorhabditis elegans biological processes: Fatty acid synthesis, xenobiotic metabolism, and stress responses
title_full_unstemmed CYP35 family in Caenorhabditis elegans biological processes: Fatty acid synthesis, xenobiotic metabolism, and stress responses
title_sort cyp35 family in caenorhabditis elegans biological processes: fatty acid synthesis, xenobiotic metabolism, and stress responses
publisher Springer Heidelberg
publishDate 2022
url http://eprints.um.edu.my/40883/
_version_ 1778161622954541056
score 13.211869

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