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Overview of the multifaceted resistances toward EGFR-TKIs and new chemotherapeutic strategies in non-small cell lung cancer

The role of epidermal growth factor receptor (EGFR) in non-small cell lung cancer (NSCLC) has been vastly studied over the last decade. This has led to the rapid development of many generations of EGFR tyrosine kinase inhibitors (EGFR-TKIs). However, patients treated with third-generation TKIs (osim...

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Main Authors: Dzulkeflee, Rashidi, Leong, Kok Hoong, Ogawa, Satoshi, Bignon, Jerome, Chan, Mun Chiang, Kong, Kin Weng
Format: Article
Published: Elsevier 2022
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R Medicine
Online Access:http://eprints.um.edu.my/40814/
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spelling my.um.eprints.408142023-09-27T03:12:10Z http://eprints.um.edu.my/40814/ Overview of the multifaceted resistances toward EGFR-TKIs and new chemotherapeutic strategies in non-small cell lung cancer Dzulkeflee, Rashidi Leong, Kok Hoong Ogawa, Satoshi Bignon, Jerome Chan, Mun Chiang Kong, Kin Weng R Medicine The role of epidermal growth factor receptor (EGFR) in non-small cell lung cancer (NSCLC) has been vastly studied over the last decade. This has led to the rapid development of many generations of EGFR tyrosine kinase inhibitors (EGFR-TKIs). However, patients treated with third-generation TKIs (osimertinib, avitinib and rociletinib) targeting the EGFR T790M mutation have shown emerging resistances and relapses. Therefore, further molecular understanding of NSCLC mutations, bypass signalling, tumour microenvironment and the existence of cancer stem cells to overcome such resistances is warranted. This will pave the way for designing novel and effective chemotherapies to improve patients' overall survival. In this review, we provide an overview of the multifaceted mechanisms of resistance towards EGFR-TKIs, as well as the challenges and perspectives that should be addressed in strategising chemotherapeutic treatments to overcome the ever-evolving and adaptive nature of NSCLC. Elsevier 2022-11 Article PeerReviewed Dzulkeflee, Rashidi and Leong, Kok Hoong and Ogawa, Satoshi and Bignon, Jerome and Chan, Mun Chiang and Kong, Kin Weng (2022) Overview of the multifaceted resistances toward EGFR-TKIs and new chemotherapeutic strategies in non-small cell lung cancer. Biochemical Pharmacology, 205. ISSN 0006-2952, DOI https://doi.org/10.1016/j.bcp.2022.115262 <https://doi.org/10.1016/j.bcp.2022.115262>. 10.1016/j.bcp.2022.115262
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Dzulkeflee, Rashidi
Leong, Kok Hoong
Ogawa, Satoshi
Bignon, Jerome
Chan, Mun Chiang
Kong, Kin Weng
Overview of the multifaceted resistances toward EGFR-TKIs and new chemotherapeutic strategies in non-small cell lung cancer
description The role of epidermal growth factor receptor (EGFR) in non-small cell lung cancer (NSCLC) has been vastly studied over the last decade. This has led to the rapid development of many generations of EGFR tyrosine kinase inhibitors (EGFR-TKIs). However, patients treated with third-generation TKIs (osimertinib, avitinib and rociletinib) targeting the EGFR T790M mutation have shown emerging resistances and relapses. Therefore, further molecular understanding of NSCLC mutations, bypass signalling, tumour microenvironment and the existence of cancer stem cells to overcome such resistances is warranted. This will pave the way for designing novel and effective chemotherapies to improve patients' overall survival. In this review, we provide an overview of the multifaceted mechanisms of resistance towards EGFR-TKIs, as well as the challenges and perspectives that should be addressed in strategising chemotherapeutic treatments to overcome the ever-evolving and adaptive nature of NSCLC.
format Article
author Dzulkeflee, Rashidi
Leong, Kok Hoong
Ogawa, Satoshi
Bignon, Jerome
Chan, Mun Chiang
Kong, Kin Weng
author_facet Dzulkeflee, Rashidi
Leong, Kok Hoong
Ogawa, Satoshi
Bignon, Jerome
Chan, Mun Chiang
Kong, Kin Weng
author_sort Dzulkeflee, Rashidi
title Overview of the multifaceted resistances toward EGFR-TKIs and new chemotherapeutic strategies in non-small cell lung cancer
title_short Overview of the multifaceted resistances toward EGFR-TKIs and new chemotherapeutic strategies in non-small cell lung cancer
title_full Overview of the multifaceted resistances toward EGFR-TKIs and new chemotherapeutic strategies in non-small cell lung cancer
title_fullStr Overview of the multifaceted resistances toward EGFR-TKIs and new chemotherapeutic strategies in non-small cell lung cancer
title_full_unstemmed Overview of the multifaceted resistances toward EGFR-TKIs and new chemotherapeutic strategies in non-small cell lung cancer
title_sort overview of the multifaceted resistances toward egfr-tkis and new chemotherapeutic strategies in non-small cell lung cancer
publisher Elsevier
publishDate 2022
url http://eprints.um.edu.my/40814/
_version_ 1781704529454039040
score 13.211869

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