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Increased beat-to-beat blood pressure variability is associated with impaired cognitive function

BACKGROUND Emerging evidence has linked visit-to-visit, day-to-day and 24-h ABPM blood pressure variability (BPV) with cognitive impairment. Few studies have, however, considered beat-to-beat BPV. This study, therefore, evaluated the relationship between beat-to-beat BPV and cognitive function among...

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Main Authors:	Asmuje, Nur Fazidah, Mat, Sumaiyah, Goh, Choon Hian, Myint, Phyo Kyaw, Tan, Maw Pin
Format:	Article
Published:	Oxford Univ Press 2022
Subjects:	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Online Access:	http://eprints.um.edu.my/40412/ https://doi.org/10.1093/ajh/hpac107
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spelling	my.um.eprints.404122024-07-15T08:15:12Z http://eprints.um.edu.my/40412/ Increased beat-to-beat blood pressure variability is associated with impaired cognitive function Asmuje, Nur Fazidah Mat, Sumaiyah Goh, Choon Hian Myint, Phyo Kyaw Tan, Maw Pin RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry BACKGROUND Emerging evidence has linked visit-to-visit, day-to-day and 24-h ABPM blood pressure variability (BPV) with cognitive impairment. Few studies have, however, considered beat-to-beat BPV. This study, therefore, evaluated the relationship between beat-to-beat BPV and cognitive function among community-dwellers aged 55 years and over. METHODS Data was obtained from the Malaysian Elders Longitudinal Research (MELoR) study, which employed random stratified sampling from three parliamentary constituencies within the Klang Valley. Beat-to-beat blood pressure (BP) was recorded using non-invasive BP monitoring (Taskforcem, CNSystems). Low frequency (LF), high frequency (HF) and low-to-high frequency (LF:HF) ratio for BPV were derived using fast Fourier transformation. Cognition was evaluated using the Montreal Cognitive Assessment (MoCA) test, and categorized into normal aging, mild impairment and moderate-to-severe impairment. RESULTS Data from 1,140 individuals, mean age (SD) 68.48 (7.23) years, were included. Individuals with moderate-to-severe impairment had higher HF-BPV for systolic (SBP) and diastolic (DBP) blood pressure compared to individuals within the normal aging group OR (95% CI) = 2.29 (1.62-3.24)] and OR (95% CI) = 1.80 (1.32-2.45)], while HF-SBPV OR (95% CI) = 1.41 (1.03-1.93)] but not HF-DBPV was significantly higher with mild impairment compared to normal aging after adjustments for potential confounders. Moderate-to-severe impairment was associated with significantly lower LF:HF-SBPV OR (95% CI) = 0.29 (0.18-0.47)] and LF:HF-DBPV OR (95% CI) = 0.49 (0.34-0.72)], while mild impairment was associated with significantly lower LF:HF-SBPV OR (95% CI) = 052 (0.34-0.80)] but not LF:HF-DBPV OR (95% CI) = 0.81 (0.57-1.17)], compared to normal aging with similar adjustments. CONCLUSION Higher HF-BPV, which indicates parasympathetic activation, and lower LF:HF-BPV, which addresses sympathovagal balance, were observed among individuals with moderate-to-severe cognitive impairment. Future studies should determine whether BPV could be a physiological marker or modifiable risk factor for cognitive decline. GRAPHICS] . Oxford Univ Press 2022-12 Article PeerReviewed Asmuje, Nur Fazidah and Mat, Sumaiyah and Goh, Choon Hian and Myint, Phyo Kyaw and Tan, Maw Pin (2022) Increased beat-to-beat blood pressure variability is associated with impaired cognitive function. American Journal of Hypertension, 35 (12). pp. 998-1005. ISSN 1941-7225, DOI https://doi.org/10.1093/ajh/hpac107 <https://doi.org/10.1093/ajh/hpac107>. https://doi.org/10.1093/ajh/hpac107 10.1093/ajh/hpac107
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
spellingShingle	RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Asmuje, Nur Fazidah Mat, Sumaiyah Goh, Choon Hian Myint, Phyo Kyaw Tan, Maw Pin Increased beat-to-beat blood pressure variability is associated with impaired cognitive function
description	BACKGROUND Emerging evidence has linked visit-to-visit, day-to-day and 24-h ABPM blood pressure variability (BPV) with cognitive impairment. Few studies have, however, considered beat-to-beat BPV. This study, therefore, evaluated the relationship between beat-to-beat BPV and cognitive function among community-dwellers aged 55 years and over. METHODS Data was obtained from the Malaysian Elders Longitudinal Research (MELoR) study, which employed random stratified sampling from three parliamentary constituencies within the Klang Valley. Beat-to-beat blood pressure (BP) was recorded using non-invasive BP monitoring (Taskforcem, CNSystems). Low frequency (LF), high frequency (HF) and low-to-high frequency (LF:HF) ratio for BPV were derived using fast Fourier transformation. Cognition was evaluated using the Montreal Cognitive Assessment (MoCA) test, and categorized into normal aging, mild impairment and moderate-to-severe impairment. RESULTS Data from 1,140 individuals, mean age (SD) 68.48 (7.23) years, were included. Individuals with moderate-to-severe impairment had higher HF-BPV for systolic (SBP) and diastolic (DBP) blood pressure compared to individuals within the normal aging group OR (95% CI) = 2.29 (1.62-3.24)] and OR (95% CI) = 1.80 (1.32-2.45)], while HF-SBPV OR (95% CI) = 1.41 (1.03-1.93)] but not HF-DBPV was significantly higher with mild impairment compared to normal aging after adjustments for potential confounders. Moderate-to-severe impairment was associated with significantly lower LF:HF-SBPV OR (95% CI) = 0.29 (0.18-0.47)] and LF:HF-DBPV OR (95% CI) = 0.49 (0.34-0.72)], while mild impairment was associated with significantly lower LF:HF-SBPV OR (95% CI) = 052 (0.34-0.80)] but not LF:HF-DBPV OR (95% CI) = 0.81 (0.57-1.17)], compared to normal aging with similar adjustments. CONCLUSION Higher HF-BPV, which indicates parasympathetic activation, and lower LF:HF-BPV, which addresses sympathovagal balance, were observed among individuals with moderate-to-severe cognitive impairment. Future studies should determine whether BPV could be a physiological marker or modifiable risk factor for cognitive decline. GRAPHICS] .
format	Article
author	Asmuje, Nur Fazidah Mat, Sumaiyah Goh, Choon Hian Myint, Phyo Kyaw Tan, Maw Pin
author_facet	Asmuje, Nur Fazidah Mat, Sumaiyah Goh, Choon Hian Myint, Phyo Kyaw Tan, Maw Pin
author_sort	Asmuje, Nur Fazidah
title	Increased beat-to-beat blood pressure variability is associated with impaired cognitive function
title_short	Increased beat-to-beat blood pressure variability is associated with impaired cognitive function
title_full	Increased beat-to-beat blood pressure variability is associated with impaired cognitive function
title_fullStr	Increased beat-to-beat blood pressure variability is associated with impaired cognitive function
title_full_unstemmed	Increased beat-to-beat blood pressure variability is associated with impaired cognitive function
title_sort	increased beat-to-beat blood pressure variability is associated with impaired cognitive function
publisher	Oxford Univ Press
publishDate	2022
url	http://eprints.um.edu.my/40412/ https://doi.org/10.1093/ajh/hpac107
_version_	1805881117242294272
score	13.211869

Increased beat-to-beat blood pressure variability is associated with impaired cognitive function

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