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Combined use of Wild-Type HBV precore and high herum iron marker as a potential tool for the prediction of cirrhosis in chronic Hepatitis B infection

Hepatitis B virus (HBV) and high liver iron deposits have both been associated with the development of cirrhosis. Among HBV factors, genotype and mutations in the basal core promoter (BCP) and precore regions have been most frequently studied but the evidence for a positive association with cirrhosi...

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Main Authors: Chook, J.B., Ngeow, Y.F., Yap, S.F., Tan, T.C., Mohamed, R.
Format: Article
Language:English
Published: 2011
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/4029/1/Chook-2011-Combined_Use_of_Wild.pdf
http://eprints.um.edu.my/4029/
http://onlinelibrary.wiley.com/store/10.1002/jmv.22016/asset/22016_ftp.pdf?v=1&t=h8az0yby&s=58b2f4f0ee673c04a7a6dd55fedc1e602db2264a
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spelling my.um.eprints.40292014-12-21T08:54:34Z http://eprints.um.edu.my/4029/ Combined use of Wild-Type HBV precore and high herum iron marker as a potential tool for the prediction of cirrhosis in chronic Hepatitis B infection Chook, J.B. Ngeow, Y.F. Yap, S.F. Tan, T.C. Mohamed, R. R Medicine Hepatitis B virus (HBV) and high liver iron deposits have both been associated with the development of cirrhosis. Among HBV factors, genotype and mutations in the basal core promoter (BCP) and precore regions have been most frequently studied but the evidence for a positive association with cirrhosis has been inconsistent. In this study, sera from persons with chronic HBV infection with and without cirrhosis were used for whole HBV genome analysis and for the estimation of serum iron marker (serum iron or ferritin) levels. Single codon analysis showed that the precore wild-type, TGG (nt 1,895-1,897), gave the highest accuracy (77.5) for the identification of cirrhosis compared to other codons. When TGG was analyzed together with the precore start codon wild-type, ATG (nt 1,814-1,816), the accuracy was improved to 80.0 (odds ratio = 35.29; 95 confidence interval = 3.87-321.93; Phi = 0.629; P < 0.001). When the serum iron marker was included for analysis, it was clear that a combination of a precore wild-type and high serum iron marker gave a better accuracy (90.0) (odds ratio = 107.67; 95 confidence interval = 10.21-1,135.59; Phi = 0.804; P < 0.001) for the identification of cirrhosis than either biomarker alone. It appeared that a combined use of both these biomarkers might help to predict the development of cirrhosis in a person with chronic HBV infection, but longitudinal studies are required to test this hypothesis. J. Med. Virol. 83:594-601, 2011. (C) 2011 Wiley-Liss, Inc. 2011 Article PeerReviewed application/pdf en http://eprints.um.edu.my/4029/1/Chook-2011-Combined_Use_of_Wild.pdf Chook, J.B. and Ngeow, Y.F. and Yap, S.F. and Tan, T.C. and Mohamed, R. (2011) Combined use of Wild-Type HBV precore and high herum iron marker as a potential tool for the prediction of cirrhosis in chronic Hepatitis B infection. Journal of Medical Virology, 83 (4). pp. 594-601. ISSN 0146-6615 http://onlinelibrary.wiley.com/store/10.1002/jmv.22016/asset/22016_ftp.pdf?v=1&t=h8az0yby&s=58b2f4f0ee673c04a7a6dd55fedc1e602db2264a 10.1002/jmv.22016
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic R Medicine
spellingShingle R Medicine
Chook, J.B.
Ngeow, Y.F.
Yap, S.F.
Tan, T.C.
Mohamed, R.
Combined use of Wild-Type HBV precore and high herum iron marker as a potential tool for the prediction of cirrhosis in chronic Hepatitis B infection
description Hepatitis B virus (HBV) and high liver iron deposits have both been associated with the development of cirrhosis. Among HBV factors, genotype and mutations in the basal core promoter (BCP) and precore regions have been most frequently studied but the evidence for a positive association with cirrhosis has been inconsistent. In this study, sera from persons with chronic HBV infection with and without cirrhosis were used for whole HBV genome analysis and for the estimation of serum iron marker (serum iron or ferritin) levels. Single codon analysis showed that the precore wild-type, TGG (nt 1,895-1,897), gave the highest accuracy (77.5) for the identification of cirrhosis compared to other codons. When TGG was analyzed together with the precore start codon wild-type, ATG (nt 1,814-1,816), the accuracy was improved to 80.0 (odds ratio = 35.29; 95 confidence interval = 3.87-321.93; Phi = 0.629; P < 0.001). When the serum iron marker was included for analysis, it was clear that a combination of a precore wild-type and high serum iron marker gave a better accuracy (90.0) (odds ratio = 107.67; 95 confidence interval = 10.21-1,135.59; Phi = 0.804; P < 0.001) for the identification of cirrhosis than either biomarker alone. It appeared that a combined use of both these biomarkers might help to predict the development of cirrhosis in a person with chronic HBV infection, but longitudinal studies are required to test this hypothesis. J. Med. Virol. 83:594-601, 2011. (C) 2011 Wiley-Liss, Inc.
format Article
author Chook, J.B.
Ngeow, Y.F.
Yap, S.F.
Tan, T.C.
Mohamed, R.
author_facet Chook, J.B.
Ngeow, Y.F.
Yap, S.F.
Tan, T.C.
Mohamed, R.
author_sort Chook, J.B.
title Combined use of Wild-Type HBV precore and high herum iron marker as a potential tool for the prediction of cirrhosis in chronic Hepatitis B infection
title_short Combined use of Wild-Type HBV precore and high herum iron marker as a potential tool for the prediction of cirrhosis in chronic Hepatitis B infection
title_full Combined use of Wild-Type HBV precore and high herum iron marker as a potential tool for the prediction of cirrhosis in chronic Hepatitis B infection
title_fullStr Combined use of Wild-Type HBV precore and high herum iron marker as a potential tool for the prediction of cirrhosis in chronic Hepatitis B infection
title_full_unstemmed Combined use of Wild-Type HBV precore and high herum iron marker as a potential tool for the prediction of cirrhosis in chronic Hepatitis B infection
title_sort combined use of wild-type hbv precore and high herum iron marker as a potential tool for the prediction of cirrhosis in chronic hepatitis b infection
publishDate 2011
url http://eprints.um.edu.my/4029/1/Chook-2011-Combined_Use_of_Wild.pdf
http://eprints.um.edu.my/4029/
http://onlinelibrary.wiley.com/store/10.1002/jmv.22016/asset/22016_ftp.pdf?v=1&t=h8az0yby&s=58b2f4f0ee673c04a7a6dd55fedc1e602db2264a
_version_ 1643687244965347328
score 13.211869

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