IL10 and IL12B polymorphisms each influence IL-12p70 secretion by dendritic cells in response to LPS
Dendritic cells (DC) are the main producers of the cytokine IL-12p70, through which they play a direct role in the development of IFN-gamma-secreting Th1 cells, costimulation of CTL differentiation and NK-cell activation. In contrast, IL-10, which is also produced by DC, negatively regulates IL-12 p...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/3972/1/Peng-2006-IL10_and_IL12B_polym.pdf http://eprints.um.edu.my/3972/ http://www.ncbi.nlm.nih.gov/pubmed/16519741 |
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