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LNCaP prostate cancer cells are insensitive to zinc-induced senescence

Prostate cancer is an age-related disease that is linked to the inability of prostate cells to accumulate zinc following transformation. It is shown in the present study the the basal percentage of normal prostate cells expressing senescence-associated beta-galactosidase (SA-beta-gal) is higher than...

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Main Authors: Wong, P.F., AbuBakar, Sazaly
Format: Article
Language:English
Published: 2008
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/3970/1/Wong-2008-LNCaP_prostate_cance.pdf
http://eprints.um.edu.my/3970/
http://www.ncbi.nlm.nih.gov/pubmed/18755400
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spelling my.um.eprints.39702019-02-13T08:10:59Z http://eprints.um.edu.my/3970/ LNCaP prostate cancer cells are insensitive to zinc-induced senescence Wong, P.F. AbuBakar, Sazaly R Medicine Prostate cancer is an age-related disease that is linked to the inability of prostate cells to accumulate zinc following transformation. It is shown in the present study the the basal percentage of normal prostate cells expressing senescence-associated beta-galactosidase (SA-beta-gal) is higher than that of the cancer cells. In the presence of high zinc in the cell culture medium, the percentage of normal prostate cells expressing the SA-beta-gal increased but not that of the cancer cells. Increased intracellular zinc occurs in the prostate cancer cells treated with supraphysiologic concentration of zinc but it does not induce senescence or decrease the telomerase activities in these cells. Senescence, however, occurred when the prostate cancer cells DNA is damaged by irradiation. These findings suggest that prostate cancer cells are insensitive to the senescence-inducing effects of zinc but the cancer cells retain the capacity to undergo senescence through other pathways. (c) 2008 Elsevier GmbH. All rights reserved. 2008 Article PeerReviewed application/pdf en http://eprints.um.edu.my/3970/1/Wong-2008-LNCaP_prostate_cance.pdf Wong, P.F. and AbuBakar, Sazaly (2008) LNCaP prostate cancer cells are insensitive to zinc-induced senescence. Journal of Trace Elements in Medicine and Biology, 22 (3). pp. 242-247. ISSN 0946-672X http://www.ncbi.nlm.nih.gov/pubmed/18755400 18755400
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic R Medicine
spellingShingle R Medicine
Wong, P.F.
AbuBakar, Sazaly
LNCaP prostate cancer cells are insensitive to zinc-induced senescence
description Prostate cancer is an age-related disease that is linked to the inability of prostate cells to accumulate zinc following transformation. It is shown in the present study the the basal percentage of normal prostate cells expressing senescence-associated beta-galactosidase (SA-beta-gal) is higher than that of the cancer cells. In the presence of high zinc in the cell culture medium, the percentage of normal prostate cells expressing the SA-beta-gal increased but not that of the cancer cells. Increased intracellular zinc occurs in the prostate cancer cells treated with supraphysiologic concentration of zinc but it does not induce senescence or decrease the telomerase activities in these cells. Senescence, however, occurred when the prostate cancer cells DNA is damaged by irradiation. These findings suggest that prostate cancer cells are insensitive to the senescence-inducing effects of zinc but the cancer cells retain the capacity to undergo senescence through other pathways. (c) 2008 Elsevier GmbH. All rights reserved.
format Article
author Wong, P.F.
AbuBakar, Sazaly
author_facet Wong, P.F.
AbuBakar, Sazaly
author_sort Wong, P.F.
title LNCaP prostate cancer cells are insensitive to zinc-induced senescence
title_short LNCaP prostate cancer cells are insensitive to zinc-induced senescence
title_full LNCaP prostate cancer cells are insensitive to zinc-induced senescence
title_fullStr LNCaP prostate cancer cells are insensitive to zinc-induced senescence
title_full_unstemmed LNCaP prostate cancer cells are insensitive to zinc-induced senescence
title_sort lncap prostate cancer cells are insensitive to zinc-induced senescence
publishDate 2008
url http://eprints.um.edu.my/3970/1/Wong-2008-LNCaP_prostate_cance.pdf
http://eprints.um.edu.my/3970/
http://www.ncbi.nlm.nih.gov/pubmed/18755400
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score 13.211869

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