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Breast milk from healthy women has higher anti-Candida properties than women with vaginal infections during pregnancy

The aim of this study was to investigate the different immunological and antimicrobial properties of breast milk from women with (W) or without (WO) vaginal yeast infections during pregnancy in 85 lactating women (W, n = 43; WO, n = 42). Concentrations of IL-10, IgA, IgM, IgG, EGF, and TGF-alpha wer...

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Main Authors: Nisaa, Azka Ainun, Oon, Chern-Ein, Sreenivasan, Sasidharan, Balakrishnan, Venugopal, Tan, Jun Jie, Teh, Cindy Shuan Ju, Sany, Salina, Todorov, Svetoslav Dimitrov, Liu, Guoxia, Park, Yong-Ha, Liong, Min-Tze
Format: Article
Published: Korean Society Food Science & Technology 2023
Subjects:
Q Science (General)
R Medicine
Online Access:http://eprints.um.edu.my/39551/
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spelling my.um.eprints.395512023-07-13T04:53:11Z http://eprints.um.edu.my/39551/ Breast milk from healthy women has higher anti-Candida properties than women with vaginal infections during pregnancy Nisaa, Azka Ainun Oon, Chern-Ein Sreenivasan, Sasidharan Balakrishnan, Venugopal Tan, Jun Jie Teh, Cindy Shuan Ju Sany, Salina Todorov, Svetoslav Dimitrov Liu, Guoxia Park, Yong-Ha Liong, Min-Tze Q Science (General) R Medicine The aim of this study was to investigate the different immunological and antimicrobial properties of breast milk from women with (W) or without (WO) vaginal yeast infections during pregnancy in 85 lactating women (W, n = 43; WO, n = 42). Concentrations of IL-10, IgA, IgM, IgG, EGF, and TGF-alpha were similar in both groups. However, breast milk of women aged below 31 years old from the W-group showed higher concentration of EGF than the WO-group (p = 0.031). Breast milk from WO-group exhibited higher anti-Candida properties than W-group, both via growth inhibition and aggregation of yeast cells (p < 0.001). Correlation analysis showed that breast milk concentration of TGF-alpha positively correlated with concentrations of IL-10 (p = 0.001) and IgA (p = 0.021) in the W-group. Data from our present study shows that although breast milk from women with vaginal infections during pregnancy may not sufficiently hinder Candida growth, other immuno-modulatory bioactives may substitute for such a protective effect. Korean Society Food Science & Technology 2023-03 Article PeerReviewed Nisaa, Azka Ainun and Oon, Chern-Ein and Sreenivasan, Sasidharan and Balakrishnan, Venugopal and Tan, Jun Jie and Teh, Cindy Shuan Ju and Sany, Salina and Todorov, Svetoslav Dimitrov and Liu, Guoxia and Park, Yong-Ha and Liong, Min-Tze (2023) Breast milk from healthy women has higher anti-Candida properties than women with vaginal infections during pregnancy. Food Science and Biotechnology, 32 (4, SI). pp. 471-480. ISSN 1226-7708, DOI https://doi.org/10.1007/s10068-022-01088-x <https://doi.org/10.1007/s10068-022-01088-x>. 10.1007/s10068-022-01088-x
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic Q Science (General)
R Medicine
spellingShingle Q Science (General)
R Medicine
Nisaa, Azka Ainun
Oon, Chern-Ein
Sreenivasan, Sasidharan
Balakrishnan, Venugopal
Tan, Jun Jie
Teh, Cindy Shuan Ju
Sany, Salina
Todorov, Svetoslav Dimitrov
Liu, Guoxia
Park, Yong-Ha
Liong, Min-Tze
Breast milk from healthy women has higher anti-Candida properties than women with vaginal infections during pregnancy
description The aim of this study was to investigate the different immunological and antimicrobial properties of breast milk from women with (W) or without (WO) vaginal yeast infections during pregnancy in 85 lactating women (W, n = 43; WO, n = 42). Concentrations of IL-10, IgA, IgM, IgG, EGF, and TGF-alpha were similar in both groups. However, breast milk of women aged below 31 years old from the W-group showed higher concentration of EGF than the WO-group (p = 0.031). Breast milk from WO-group exhibited higher anti-Candida properties than W-group, both via growth inhibition and aggregation of yeast cells (p < 0.001). Correlation analysis showed that breast milk concentration of TGF-alpha positively correlated with concentrations of IL-10 (p = 0.001) and IgA (p = 0.021) in the W-group. Data from our present study shows that although breast milk from women with vaginal infections during pregnancy may not sufficiently hinder Candida growth, other immuno-modulatory bioactives may substitute for such a protective effect.
format Article
author Nisaa, Azka Ainun
Oon, Chern-Ein
Sreenivasan, Sasidharan
Balakrishnan, Venugopal
Tan, Jun Jie
Teh, Cindy Shuan Ju
Sany, Salina
Todorov, Svetoslav Dimitrov
Liu, Guoxia
Park, Yong-Ha
Liong, Min-Tze
author_facet Nisaa, Azka Ainun
Oon, Chern-Ein
Sreenivasan, Sasidharan
Balakrishnan, Venugopal
Tan, Jun Jie
Teh, Cindy Shuan Ju
Sany, Salina
Todorov, Svetoslav Dimitrov
Liu, Guoxia
Park, Yong-Ha
Liong, Min-Tze
author_sort Nisaa, Azka Ainun
title Breast milk from healthy women has higher anti-Candida properties than women with vaginal infections during pregnancy
title_short Breast milk from healthy women has higher anti-Candida properties than women with vaginal infections during pregnancy
title_full Breast milk from healthy women has higher anti-Candida properties than women with vaginal infections during pregnancy
title_fullStr Breast milk from healthy women has higher anti-Candida properties than women with vaginal infections during pregnancy
title_full_unstemmed Breast milk from healthy women has higher anti-Candida properties than women with vaginal infections during pregnancy
title_sort breast milk from healthy women has higher anti-candida properties than women with vaginal infections during pregnancy
publisher Korean Society Food Science & Technology
publishDate 2023
url http://eprints.um.edu.my/39551/
_version_ 1772811759851143168
score 13.211869

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