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Can metagenomics unravel the impact of oral bacteriome in human diseases?

Oral microbial ecosystems are vital in maintaining the health of the oral cavity and the entire body. Oral microbiota is associated with the progression of oral diseases such as dental caries, periodontal diseases, head and neck cancer, and several systemic diseases such as cardiovascular disease, r...

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Main Authors: Chattopadhyay, Indranil, Lu, Wenying, Manikam, Rishya, Malarvili, M. B., Ambati, Ranga Rao, Gundamaraju, Rohit
Format: Article
Published: Taylor & Francis Ltd 2023
Subjects:
QR Microbiology
R Medicine
Online Access:http://eprints.um.edu.my/39496/
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spelling my.um.eprints.394962023-07-13T02:33:06Z http://eprints.um.edu.my/39496/ Can metagenomics unravel the impact of oral bacteriome in human diseases? Chattopadhyay, Indranil Lu, Wenying Manikam, Rishya Malarvili, M. B. Ambati, Ranga Rao Gundamaraju, Rohit QR Microbiology R Medicine Oral microbial ecosystems are vital in maintaining the health of the oral cavity and the entire body. Oral microbiota is associated with the progression of oral diseases such as dental caries, periodontal diseases, head and neck cancer, and several systemic diseases such as cardiovascular disease, rheumatoid arthritis, adverse pregnancy outcomes, diabetes, lung infection, colorectal cancer, and pancreatic cancer. Buccal mucosa, tongue dorsum, hard palate, saliva, palatine tonsils, throat, keratinized gingiva, supra-gingival plaque, subgingival plaque, dentures, and lips are microbial habitats of the oral cavity. Porphyromonas gingivalis may have a role in the development of periodontal diseases, oral cancer, diabetes, and atherosclerotic disease. Fusobacterium nucleatum showed a higher abundance in periodontal diseases, oral and colon cancer, adverse pregnancy outcomes, diabetes, and rheumatoid arthritis. The higher abundance of Prevotella intermedia is typical in periodontal diseases, rheumatoid arthritis, and adverse pregnancy outcome. S. salivarius displayed higher abundance in both dental caries and OSCC. Oral bacteria may influence systemic diseases through inflammation by releasing pro inflammatory cytokines. Identification of oral bacteria using culture-dependent approaches and next-generation sequencing-based metagenomic approaches is believed to significantly identify the therapeutic targets and non-invasive diagnostic indicators in different human diseases. Oral bacteria in saliva could be exploited as a non-invasive diagnostic indicator for the early detection of oral and systemic disorders. Other therapeutic approaches such as the use of probiotics, green tea polyphenol, cold atmospheric plasma (CAP) therapy, antimicrobial photodynamic therapy, and antimicrobial peptides are used to inhibit the growth of biofilm formation by oral bacteria. Taylor & Francis Ltd 2023-01 Article PeerReviewed Chattopadhyay, Indranil and Lu, Wenying and Manikam, Rishya and Malarvili, M. B. and Ambati, Ranga Rao and Gundamaraju, Rohit (2023) Can metagenomics unravel the impact of oral bacteriome in human diseases? Biotechnology and Genetic Engineering Reviews, 39 (1). pp. 85-117. ISSN 0264-8725, DOI https://doi.org/10.1080/02648725.2022.2102877 <https://doi.org/10.1080/02648725.2022.2102877>. 10.1080/02648725.2022.2102877
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QR Microbiology
R Medicine
spellingShingle QR Microbiology
R Medicine
Chattopadhyay, Indranil
Lu, Wenying
Manikam, Rishya
Malarvili, M. B.
Ambati, Ranga Rao
Gundamaraju, Rohit
Can metagenomics unravel the impact of oral bacteriome in human diseases?
description Oral microbial ecosystems are vital in maintaining the health of the oral cavity and the entire body. Oral microbiota is associated with the progression of oral diseases such as dental caries, periodontal diseases, head and neck cancer, and several systemic diseases such as cardiovascular disease, rheumatoid arthritis, adverse pregnancy outcomes, diabetes, lung infection, colorectal cancer, and pancreatic cancer. Buccal mucosa, tongue dorsum, hard palate, saliva, palatine tonsils, throat, keratinized gingiva, supra-gingival plaque, subgingival plaque, dentures, and lips are microbial habitats of the oral cavity. Porphyromonas gingivalis may have a role in the development of periodontal diseases, oral cancer, diabetes, and atherosclerotic disease. Fusobacterium nucleatum showed a higher abundance in periodontal diseases, oral and colon cancer, adverse pregnancy outcomes, diabetes, and rheumatoid arthritis. The higher abundance of Prevotella intermedia is typical in periodontal diseases, rheumatoid arthritis, and adverse pregnancy outcome. S. salivarius displayed higher abundance in both dental caries and OSCC. Oral bacteria may influence systemic diseases through inflammation by releasing pro inflammatory cytokines. Identification of oral bacteria using culture-dependent approaches and next-generation sequencing-based metagenomic approaches is believed to significantly identify the therapeutic targets and non-invasive diagnostic indicators in different human diseases. Oral bacteria in saliva could be exploited as a non-invasive diagnostic indicator for the early detection of oral and systemic disorders. Other therapeutic approaches such as the use of probiotics, green tea polyphenol, cold atmospheric plasma (CAP) therapy, antimicrobial photodynamic therapy, and antimicrobial peptides are used to inhibit the growth of biofilm formation by oral bacteria.
format Article
author Chattopadhyay, Indranil
Lu, Wenying
Manikam, Rishya
Malarvili, M. B.
Ambati, Ranga Rao
Gundamaraju, Rohit
author_facet Chattopadhyay, Indranil
Lu, Wenying
Manikam, Rishya
Malarvili, M. B.
Ambati, Ranga Rao
Gundamaraju, Rohit
author_sort Chattopadhyay, Indranil
title Can metagenomics unravel the impact of oral bacteriome in human diseases?
title_short Can metagenomics unravel the impact of oral bacteriome in human diseases?
title_full Can metagenomics unravel the impact of oral bacteriome in human diseases?
title_fullStr Can metagenomics unravel the impact of oral bacteriome in human diseases?
title_full_unstemmed Can metagenomics unravel the impact of oral bacteriome in human diseases?
title_sort can metagenomics unravel the impact of oral bacteriome in human diseases?
publisher Taylor & Francis Ltd
publishDate 2023
url http://eprints.um.edu.my/39496/
_version_ 1772811759094071296
score 13.211869

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