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Development of a single-run liquid chromatography-mass spectrometry analysis for the detection of 11 multiclass contaminants of emerging concern using a direct filtration method

In toxicological analysis, the analytical validation method is important to assess the exact risk of contaminants of emerging concern in the environment. Syringe filters are mainly used to remove impurities from sample solutions. However, the loss of analyte to the syringe filter could be considerab...

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Main Authors: Razak, Muhammad Raznisyafiq, Aris, Ahmad Zaharin, Sukatis, Fahren Fazzer, Zaki, Muhammad Rozaimi Mohd, Zainuddin, Azim Haziq, Haron, Didi Erwandi Mohamad, Yusoff, Fatimah Md, Yusof, Zetty Norhana Balia
Format: Article
Published: Wiley 2023
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QD Chemistry
Online Access:http://eprints.um.edu.my/39332/
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spelling my.um.eprints.393322023-11-24T07:26:17Z http://eprints.um.edu.my/39332/ Development of a single-run liquid chromatography-mass spectrometry analysis for the detection of 11 multiclass contaminants of emerging concern using a direct filtration method Razak, Muhammad Raznisyafiq Aris, Ahmad Zaharin Sukatis, Fahren Fazzer Zaki, Muhammad Rozaimi Mohd Zainuddin, Azim Haziq Haron, Didi Erwandi Mohamad Yusoff, Fatimah Md Yusof, Zetty Norhana Balia QD Chemistry In toxicological analysis, the analytical validation method is important to assess the exact risk of contaminants of emerging concern in the environment. Syringe filters are mainly used to remove impurities from sample solutions. However, the loss of analyte to the syringe filter could be considerable, causing an underestimate of the analyte concentrations. The current study develops and validates simultaneous liquid chromatography-mass spectrometry analysis using a direct filtration method to detect four groups of contaminants of emerging concern. The adsorption of the analyte onto three different matrices and six types of syringe filters is reported. The lowest adsorption of analytes was observed in methanol (16.72%), followed by deionized water (48.19%) and filtered surface lake water (48.94%). Irrespective of the type of the matrices, the lowest average adsorption by the syringe filter was observed in the 0.45 mu m polypropylene membrane (15.15%), followed by the 0.20 mu m polypropylene membrane (16.10%), the 0.20 mu m regenerated cellulose (16.15%), the 0.20 mu m polytetrafluoroethylene membrane (47.38%), the 0.45 mu m nylon membrane (64.87%) and the 0.20 mu m nylon membrane (71.30%). In conclusion, the recommended syringe filter membranes for contaminants of emerging concern analysis are polypropylene membranes and regenerated cellulose, regardless of the matrix used. Wiley 2023-01 Article PeerReviewed Razak, Muhammad Raznisyafiq and Aris, Ahmad Zaharin and Sukatis, Fahren Fazzer and Zaki, Muhammad Rozaimi Mohd and Zainuddin, Azim Haziq and Haron, Didi Erwandi Mohamad and Yusoff, Fatimah Md and Yusof, Zetty Norhana Balia (2023) Development of a single-run liquid chromatography-mass spectrometry analysis for the detection of 11 multiclass contaminants of emerging concern using a direct filtration method. Journal of Separation Science, 46 (1). ISSN 1615-9306, DOI https://doi.org/10.1002/jssc.202200282 <https://doi.org/10.1002/jssc.202200282>. 10.1002/jssc.202200282
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic QD Chemistry
spellingShingle QD Chemistry
Razak, Muhammad Raznisyafiq
Aris, Ahmad Zaharin
Sukatis, Fahren Fazzer
Zaki, Muhammad Rozaimi Mohd
Zainuddin, Azim Haziq
Haron, Didi Erwandi Mohamad
Yusoff, Fatimah Md
Yusof, Zetty Norhana Balia
Development of a single-run liquid chromatography-mass spectrometry analysis for the detection of 11 multiclass contaminants of emerging concern using a direct filtration method
description In toxicological analysis, the analytical validation method is important to assess the exact risk of contaminants of emerging concern in the environment. Syringe filters are mainly used to remove impurities from sample solutions. However, the loss of analyte to the syringe filter could be considerable, causing an underestimate of the analyte concentrations. The current study develops and validates simultaneous liquid chromatography-mass spectrometry analysis using a direct filtration method to detect four groups of contaminants of emerging concern. The adsorption of the analyte onto three different matrices and six types of syringe filters is reported. The lowest adsorption of analytes was observed in methanol (16.72%), followed by deionized water (48.19%) and filtered surface lake water (48.94%). Irrespective of the type of the matrices, the lowest average adsorption by the syringe filter was observed in the 0.45 mu m polypropylene membrane (15.15%), followed by the 0.20 mu m polypropylene membrane (16.10%), the 0.20 mu m regenerated cellulose (16.15%), the 0.20 mu m polytetrafluoroethylene membrane (47.38%), the 0.45 mu m nylon membrane (64.87%) and the 0.20 mu m nylon membrane (71.30%). In conclusion, the recommended syringe filter membranes for contaminants of emerging concern analysis are polypropylene membranes and regenerated cellulose, regardless of the matrix used.
format Article
author Razak, Muhammad Raznisyafiq
Aris, Ahmad Zaharin
Sukatis, Fahren Fazzer
Zaki, Muhammad Rozaimi Mohd
Zainuddin, Azim Haziq
Haron, Didi Erwandi Mohamad
Yusoff, Fatimah Md
Yusof, Zetty Norhana Balia
author_facet Razak, Muhammad Raznisyafiq
Aris, Ahmad Zaharin
Sukatis, Fahren Fazzer
Zaki, Muhammad Rozaimi Mohd
Zainuddin, Azim Haziq
Haron, Didi Erwandi Mohamad
Yusoff, Fatimah Md
Yusof, Zetty Norhana Balia
author_sort Razak, Muhammad Raznisyafiq
title Development of a single-run liquid chromatography-mass spectrometry analysis for the detection of 11 multiclass contaminants of emerging concern using a direct filtration method
title_short Development of a single-run liquid chromatography-mass spectrometry analysis for the detection of 11 multiclass contaminants of emerging concern using a direct filtration method
title_full Development of a single-run liquid chromatography-mass spectrometry analysis for the detection of 11 multiclass contaminants of emerging concern using a direct filtration method
title_fullStr Development of a single-run liquid chromatography-mass spectrometry analysis for the detection of 11 multiclass contaminants of emerging concern using a direct filtration method
title_full_unstemmed Development of a single-run liquid chromatography-mass spectrometry analysis for the detection of 11 multiclass contaminants of emerging concern using a direct filtration method
title_sort development of a single-run liquid chromatography-mass spectrometry analysis for the detection of 11 multiclass contaminants of emerging concern using a direct filtration method
publisher Wiley
publishDate 2023
url http://eprints.um.edu.my/39332/
_version_ 1783876684939788288
score 13.211869

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