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SLC1A2 gene polymorphism influences methamphetamine-induced psychosis

SLC1A2 is a gene encoded for the excitatory amino acid transporter 2 which is responsible for glutamate reuptake from the synaptic cleft in the central nervous system. Recent studies have suggested that polymorphisms on glutamate transporters can affect drug dependence, leading to the development of...

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Main Authors: Yahya, Dayang Nooreffazleen, Guad, Rhanye Mac, Wu, Yuan-Seng, Gan, Siew Hua, Gopinath, Subash C. B., Zakariah, Hasif Adli, Rashid, Rusdi Abdul, Sim, Maw Shin
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Published: MDPI 2023
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Q Science (General)
R Medicine (General)
Online Access:http://eprints.um.edu.my/38748/
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spelling my.um.eprints.387482024-11-18T02:11:49Z http://eprints.um.edu.my/38748/ SLC1A2 gene polymorphism influences methamphetamine-induced psychosis Yahya, Dayang Nooreffazleen Guad, Rhanye Mac Wu, Yuan-Seng Gan, Siew Hua Gopinath, Subash C. B. Zakariah, Hasif Adli Rashid, Rusdi Abdul Sim, Maw Shin Q Science (General) R Medicine (General) SLC1A2 is a gene encoded for the excitatory amino acid transporter 2 which is responsible for glutamate reuptake from the synaptic cleft in the central nervous system. Recent studies have suggested that polymorphisms on glutamate transporters can affect drug dependence, leading to the development of neurological diseases and psychiatric disorders. Our study investigated the association of rs4755404 single nucleotide polymorphism (SNP) of the SLC1A2 gene with methamphetamine (METH) dependence and METH-induced psychosis and mania in a Malaysian population. The rs4755404 gene polymorphism was genotyped in METH-dependent male subjects (n = 285) and male control subjects (n = 251). The subjects consisted of the four ethnic groups in Malaysia (Malay, Chinese, Kadazan-Dusun, and Bajau). Interestingly, there was a significant association between rs4755404 polymorphism and METH-induced psychosis in the pooled METH-dependent subjects in terms of genotype frequency (p = 0.041). However, there was no significant association between rs4755404 polymorphism and METH dependence. Also, the rs455404 polymorphism was not significantly associated with METH-induced mania for both genotype frequencies and allele frequencies in the METH-dependent subjects, regardless of stratification into the different ethnicities. Our study suggests that the SLC1A2 rs4755404 gene polymorphism confers some susceptibility to METH-induced psychosis, especially for those who carry the GG homozygous genotype. MDPI 2023-02 Article PeerReviewed Yahya, Dayang Nooreffazleen and Guad, Rhanye Mac and Wu, Yuan-Seng and Gan, Siew Hua and Gopinath, Subash C. B. and Zakariah, Hasif Adli and Rashid, Rusdi Abdul and Sim, Maw Shin (2023) SLC1A2 gene polymorphism influences methamphetamine-induced psychosis. Journal of Personalized Medicine, 13 (2). ISSN 2075-4426, DOI https://doi.org/10.3390/jpm13020270 <https://doi.org/10.3390/jpm13020270>. 10.3390/jpm13020270
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic Q Science (General)
R Medicine (General)
spellingShingle Q Science (General)
R Medicine (General)
Yahya, Dayang Nooreffazleen
Guad, Rhanye Mac
Wu, Yuan-Seng
Gan, Siew Hua
Gopinath, Subash C. B.
Zakariah, Hasif Adli
Rashid, Rusdi Abdul
Sim, Maw Shin
SLC1A2 gene polymorphism influences methamphetamine-induced psychosis
description SLC1A2 is a gene encoded for the excitatory amino acid transporter 2 which is responsible for glutamate reuptake from the synaptic cleft in the central nervous system. Recent studies have suggested that polymorphisms on glutamate transporters can affect drug dependence, leading to the development of neurological diseases and psychiatric disorders. Our study investigated the association of rs4755404 single nucleotide polymorphism (SNP) of the SLC1A2 gene with methamphetamine (METH) dependence and METH-induced psychosis and mania in a Malaysian population. The rs4755404 gene polymorphism was genotyped in METH-dependent male subjects (n = 285) and male control subjects (n = 251). The subjects consisted of the four ethnic groups in Malaysia (Malay, Chinese, Kadazan-Dusun, and Bajau). Interestingly, there was a significant association between rs4755404 polymorphism and METH-induced psychosis in the pooled METH-dependent subjects in terms of genotype frequency (p = 0.041). However, there was no significant association between rs4755404 polymorphism and METH dependence. Also, the rs455404 polymorphism was not significantly associated with METH-induced mania for both genotype frequencies and allele frequencies in the METH-dependent subjects, regardless of stratification into the different ethnicities. Our study suggests that the SLC1A2 rs4755404 gene polymorphism confers some susceptibility to METH-induced psychosis, especially for those who carry the GG homozygous genotype.
format Article
author Yahya, Dayang Nooreffazleen
Guad, Rhanye Mac
Wu, Yuan-Seng
Gan, Siew Hua
Gopinath, Subash C. B.
Zakariah, Hasif Adli
Rashid, Rusdi Abdul
Sim, Maw Shin
author_facet Yahya, Dayang Nooreffazleen
Guad, Rhanye Mac
Wu, Yuan-Seng
Gan, Siew Hua
Gopinath, Subash C. B.
Zakariah, Hasif Adli
Rashid, Rusdi Abdul
Sim, Maw Shin
author_sort Yahya, Dayang Nooreffazleen
title SLC1A2 gene polymorphism influences methamphetamine-induced psychosis
title_short SLC1A2 gene polymorphism influences methamphetamine-induced psychosis
title_full SLC1A2 gene polymorphism influences methamphetamine-induced psychosis
title_fullStr SLC1A2 gene polymorphism influences methamphetamine-induced psychosis
title_full_unstemmed SLC1A2 gene polymorphism influences methamphetamine-induced psychosis
title_sort slc1a2 gene polymorphism influences methamphetamine-induced psychosis
publisher MDPI
publishDate 2023
url http://eprints.um.edu.my/38748/
_version_ 1817841937539923968
score 13.222552

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