Cover Image

MtDNA control region sequence polymorphisms and phylogenetic analysis of Malay population living in or around Kuala Lumpur in Malaysia

Control region polymorphisms in the mitochondrial DNA of 124 unrelated individuals from the Malay population living in or around Kuala Lumpur in Malaysia were investigated and phylogenetic haplogroup lineages were determined. The intergenic COII/tRNALys 9-bp deletion, 3010 and 5178 mutations, and se...

Full description

Saved in:
Bibliographic Details
Main Authors: Maruyama, S., Nohira-Koike, C., Minaguchi, K., Nambiar, P.
Format: Article
Language:English
English
Published: 2010
Subjects:
RK Dentistry
Online Access:http://eprints.um.edu.my/3863/1/MtDNA_control_region_sequence_polymorphisms.pdf
http://eprints.um.edu.my/3863/2/MtDNA_control_region_sequence_polymorphisms_and_phylogenetic_analysis_of_Malay_population_living_in_or_around_Kuala_Lumpur_in_Malaysia.pdf
http://eprints.um.edu.my/3863/
Tags: Add Tag
No Tags, Be the first to tag this record!
id my.um.eprints.3863
record_format eprints
spelling my.um.eprints.38632012-11-02T01:30:58Z http://eprints.um.edu.my/3863/ MtDNA control region sequence polymorphisms and phylogenetic analysis of Malay population living in or around Kuala Lumpur in Malaysia Maruyama, S. Nohira-Koike, C. Minaguchi, K. Nambiar, P. RK Dentistry Control region polymorphisms in the mitochondrial DNA of 124 unrelated individuals from the Malay population living in or around Kuala Lumpur in Malaysia were investigated and phylogenetic haplogroup lineages were determined. The intergenic COII/tRNALys 9-bp deletion, 3010 and 5178 mutations, and several coding region polymorphisms were examined to discriminate some phylogenetic haplogroups. Sequence comparison of the control regions led to the identification of 117 mitochondrial haplotypes, in which 103 types were observed in only one individual and the other nine types were shared by more than two individuals. Gene diversity was estimated to be 0.997. Phylogenetic haplogroup determination revealed that the gene pool of the modern Malay population in Malaysia consisted mainly of southeast Asian, east Asian, unidentified and unique, and aboriginal southeast-specific haplogroups. These results suggest a multi-original nature for the modern Malay population. The present database may help not only in personal identification but also in determining geographic origin in forensic casework in Malaysian, Southeast Asian and East Asian populations. 2010 Article PeerReviewed application/pdf en http://eprints.um.edu.my/3863/1/MtDNA_control_region_sequence_polymorphisms.pdf application/pdf en http://eprints.um.edu.my/3863/2/MtDNA_control_region_sequence_polymorphisms_and_phylogenetic_analysis_of_Malay_population_living_in_or_around_Kuala_Lumpur_in_Malaysia.pdf Maruyama, S. and Nohira-Koike, C. and Minaguchi, K. and Nambiar, P. (2010) MtDNA control region sequence polymorphisms and phylogenetic analysis of Malay population living in or around Kuala Lumpur in Malaysia. International Journal of Legal Medicine, 124 (2). pp. 165-170. ISSN 0937-9827 10.1007/s00414-009-0355-6
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
English
topic RK Dentistry
spellingShingle RK Dentistry
Maruyama, S.
Nohira-Koike, C.
Minaguchi, K.
Nambiar, P.
MtDNA control region sequence polymorphisms and phylogenetic analysis of Malay population living in or around Kuala Lumpur in Malaysia
description Control region polymorphisms in the mitochondrial DNA of 124 unrelated individuals from the Malay population living in or around Kuala Lumpur in Malaysia were investigated and phylogenetic haplogroup lineages were determined. The intergenic COII/tRNALys 9-bp deletion, 3010 and 5178 mutations, and several coding region polymorphisms were examined to discriminate some phylogenetic haplogroups. Sequence comparison of the control regions led to the identification of 117 mitochondrial haplotypes, in which 103 types were observed in only one individual and the other nine types were shared by more than two individuals. Gene diversity was estimated to be 0.997. Phylogenetic haplogroup determination revealed that the gene pool of the modern Malay population in Malaysia consisted mainly of southeast Asian, east Asian, unidentified and unique, and aboriginal southeast-specific haplogroups. These results suggest a multi-original nature for the modern Malay population. The present database may help not only in personal identification but also in determining geographic origin in forensic casework in Malaysian, Southeast Asian and East Asian populations.
format Article
author Maruyama, S.
Nohira-Koike, C.
Minaguchi, K.
Nambiar, P.
author_facet Maruyama, S.
Nohira-Koike, C.
Minaguchi, K.
Nambiar, P.
author_sort Maruyama, S.
title MtDNA control region sequence polymorphisms and phylogenetic analysis of Malay population living in or around Kuala Lumpur in Malaysia
title_short MtDNA control region sequence polymorphisms and phylogenetic analysis of Malay population living in or around Kuala Lumpur in Malaysia
title_full MtDNA control region sequence polymorphisms and phylogenetic analysis of Malay population living in or around Kuala Lumpur in Malaysia
title_fullStr MtDNA control region sequence polymorphisms and phylogenetic analysis of Malay population living in or around Kuala Lumpur in Malaysia
title_full_unstemmed MtDNA control region sequence polymorphisms and phylogenetic analysis of Malay population living in or around Kuala Lumpur in Malaysia
title_sort mtdna control region sequence polymorphisms and phylogenetic analysis of malay population living in or around kuala lumpur in malaysia
publishDate 2010
url http://eprints.um.edu.my/3863/1/MtDNA_control_region_sequence_polymorphisms.pdf
http://eprints.um.edu.my/3863/2/MtDNA_control_region_sequence_polymorphisms_and_phylogenetic_analysis_of_Malay_population_living_in_or_around_Kuala_Lumpur_in_Malaysia.pdf
http://eprints.um.edu.my/3863/
_version_ 1643687215481487360
score 13.211869

Similar Items