Staff View: Genetic markers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease

Genetic markers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease

Type 2 diabetes mellitus (T2DM) is characterized by impaired insulin secretion on a background of insulin resistance (IR). IR and T2DM are associated with atherosclerotic coronary artery disease (CAD). The mechanisms of IR and atherosclerosis are known to share similar genetic and environmental root...

Full description

Saved in:

Bibliographic Details
Main Authors:	Perumalsamy, Sangeetha, Zaman Huri, Hasniza, Abdullah, Bashar Mudhaffar, Mazlan, Othman, Wan Ahmad, Wan Azman, Vethakkan, Shireene Ratna D. B.
Format:	Article
Published:	MDPI 2023
Subjects:	RC Internal medicine
Online Access:	http://eprints.um.edu.my/38539/
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my.um.eprints.38539
record_format	eprints
spelling	my.um.eprints.385392023-11-30T06:09:53Z http://eprints.um.edu.my/38539/ Genetic markers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease Perumalsamy, Sangeetha Zaman Huri, Hasniza Abdullah, Bashar Mudhaffar Mazlan, Othman Wan Ahmad, Wan Azman Vethakkan, Shireene Ratna D. B. RC Internal medicine Type 2 diabetes mellitus (T2DM) is characterized by impaired insulin secretion on a background of insulin resistance (IR). IR and T2DM are associated with atherosclerotic coronary artery disease (CAD). The mechanisms of IR and atherosclerosis are known to share similar genetic and environmental roots. Endothelial dysfunction (ED) detected at the earliest stages of IR might be the origin of atherosclerosis progression. ED influences the secretion of pro-inflammatory cytokines and their encoding genes. The genes and their single nucleotide polymorphisms (SNPs) act as potential genetic markers of IR and atherosclerosis. This review focuses on the link between IR, T2DM, atherosclerosis, CAD, and the potential genetic markers CHI3L1, CD36, LEPR, RETN, IL-18, RBP-4, and RARRES2 genes. MDPI 2023-03 Article PeerReviewed Perumalsamy, Sangeetha and Zaman Huri, Hasniza and Abdullah, Bashar Mudhaffar and Mazlan, Othman and Wan Ahmad, Wan Azman and Vethakkan, Shireene Ratna D. B. (2023) Genetic markers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease. Metabolities, 13 (3). ISSN 2218-1989, DOI https://doi.org/10.3390/metabo13030427 <https://doi.org/10.3390/metabo13030427>. 10.3390/metabo13030427
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	RC Internal medicine
spellingShingle	RC Internal medicine Perumalsamy, Sangeetha Zaman Huri, Hasniza Abdullah, Bashar Mudhaffar Mazlan, Othman Wan Ahmad, Wan Azman Vethakkan, Shireene Ratna D. B. Genetic markers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease
description	Type 2 diabetes mellitus (T2DM) is characterized by impaired insulin secretion on a background of insulin resistance (IR). IR and T2DM are associated with atherosclerotic coronary artery disease (CAD). The mechanisms of IR and atherosclerosis are known to share similar genetic and environmental roots. Endothelial dysfunction (ED) detected at the earliest stages of IR might be the origin of atherosclerosis progression. ED influences the secretion of pro-inflammatory cytokines and their encoding genes. The genes and their single nucleotide polymorphisms (SNPs) act as potential genetic markers of IR and atherosclerosis. This review focuses on the link between IR, T2DM, atherosclerosis, CAD, and the potential genetic markers CHI3L1, CD36, LEPR, RETN, IL-18, RBP-4, and RARRES2 genes.
format	Article
author	Perumalsamy, Sangeetha Zaman Huri, Hasniza Abdullah, Bashar Mudhaffar Mazlan, Othman Wan Ahmad, Wan Azman Vethakkan, Shireene Ratna D. B.
author_facet	Perumalsamy, Sangeetha Zaman Huri, Hasniza Abdullah, Bashar Mudhaffar Mazlan, Othman Wan Ahmad, Wan Azman Vethakkan, Shireene Ratna D. B.
author_sort	Perumalsamy, Sangeetha
title	Genetic markers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease
title_short	Genetic markers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease
title_full	Genetic markers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease
title_fullStr	Genetic markers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease
title_full_unstemmed	Genetic markers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease
title_sort	genetic markers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease
publisher	MDPI
publishDate	2023
url	http://eprints.um.edu.my/38539/
_version_	1784511841781678080
score	13.211869

Genetic markers of insulin resistance and atherosclerosis in type 2 diabetes mellitus patients with coronary artery disease

Similar Items