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Recent progress on nanocarriers for Topical-Mediated RNAi Strategies for crop protection: A review

To fulfil the growing needs of the global population, sustainability in food production must be ensured. Insect pests and pathogens are primarily responsible for one-third of food losses and harmful synthetic pesticides have been applied to protect crops from these pests and other pathogens such as...

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Main Authors: Nurzatil Sharleeza, Mat Jalaluddin, Asem, Maimunah, Harikrishna, Jennifer Ann, Fuaad, Abdullah Al Hadi Ahmad
Format: Article
Published: MDPI 2023
Subjects:
Q Science (General)
QD Chemistry
QH301 Biology
Online Access:http://eprints.um.edu.my/38509/
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spelling my.um.eprints.385092024-07-22T04:11:40Z http://eprints.um.edu.my/38509/ Recent progress on nanocarriers for Topical-Mediated RNAi Strategies for crop protection: A review Nurzatil Sharleeza, Mat Jalaluddin Asem, Maimunah Harikrishna, Jennifer Ann Fuaad, Abdullah Al Hadi Ahmad Q Science (General) QD Chemistry QH301 Biology To fulfil the growing needs of the global population, sustainability in food production must be ensured. Insect pests and pathogens are primarily responsible for one-third of food losses and harmful synthetic pesticides have been applied to protect crops from these pests and other pathogens such as viruses and fungi. An alternative pathogen control mechanism that is more ``friendly'' to the environment can be developed by externally applying double-stranded RNAs (dsRNAs) to suppress gene expression. However, the use of dsRNA sprays in open fields is complicated with respect to variable efficiencies in the dsRNA delivery, and the stability of the dsRNA on and in the plants, and because the mechanisms of gene silencing may differ between plants and between different pathogen targets. Thus, nanocarrier delivery systems have been especially used with the goal of improving the efficacy of dsRNAs. Here, we highlight recent developments in nanoparticle-mediated nanocarriers to deliver dsRNA, including layered double hydroxide, carbon dots, carbon nanotubes, gold nanoparticles, chitosan nanoparticles, silica nanoparticles, liposomes, and cell-penetrating peptides, by review of the literature and patent landscape. The effects of nanoparticle size and surface modification on the dsRNA uptake efficiency in plants are also discussed. Finally, we emphasize the overall limitation of dsRNA sprays, the risks associated, and the potential safety concerns for spraying dsRNAs on crops. MDPI 2023-03 Article PeerReviewed Nurzatil Sharleeza, Mat Jalaluddin and Asem, Maimunah and Harikrishna, Jennifer Ann and Fuaad, Abdullah Al Hadi Ahmad (2023) Recent progress on nanocarriers for Topical-Mediated RNAi Strategies for crop protection: A review. Molecules, 28 (6). ISSN 1420-3049, DOI https://doi.org/10.3390/molecules28062700 <https://doi.org/10.3390/molecules28062700>. 10.3390/molecules28062700
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic Q Science (General)
QD Chemistry
QH301 Biology
spellingShingle Q Science (General)
QD Chemistry
QH301 Biology
Nurzatil Sharleeza, Mat Jalaluddin
Asem, Maimunah
Harikrishna, Jennifer Ann
Fuaad, Abdullah Al Hadi Ahmad
Recent progress on nanocarriers for Topical-Mediated RNAi Strategies for crop protection: A review
description To fulfil the growing needs of the global population, sustainability in food production must be ensured. Insect pests and pathogens are primarily responsible for one-third of food losses and harmful synthetic pesticides have been applied to protect crops from these pests and other pathogens such as viruses and fungi. An alternative pathogen control mechanism that is more ``friendly'' to the environment can be developed by externally applying double-stranded RNAs (dsRNAs) to suppress gene expression. However, the use of dsRNA sprays in open fields is complicated with respect to variable efficiencies in the dsRNA delivery, and the stability of the dsRNA on and in the plants, and because the mechanisms of gene silencing may differ between plants and between different pathogen targets. Thus, nanocarrier delivery systems have been especially used with the goal of improving the efficacy of dsRNAs. Here, we highlight recent developments in nanoparticle-mediated nanocarriers to deliver dsRNA, including layered double hydroxide, carbon dots, carbon nanotubes, gold nanoparticles, chitosan nanoparticles, silica nanoparticles, liposomes, and cell-penetrating peptides, by review of the literature and patent landscape. The effects of nanoparticle size and surface modification on the dsRNA uptake efficiency in plants are also discussed. Finally, we emphasize the overall limitation of dsRNA sprays, the risks associated, and the potential safety concerns for spraying dsRNAs on crops.
format Article
author Nurzatil Sharleeza, Mat Jalaluddin
Asem, Maimunah
Harikrishna, Jennifer Ann
Fuaad, Abdullah Al Hadi Ahmad
author_facet Nurzatil Sharleeza, Mat Jalaluddin
Asem, Maimunah
Harikrishna, Jennifer Ann
Fuaad, Abdullah Al Hadi Ahmad
author_sort Nurzatil Sharleeza, Mat Jalaluddin
title Recent progress on nanocarriers for Topical-Mediated RNAi Strategies for crop protection: A review
title_short Recent progress on nanocarriers for Topical-Mediated RNAi Strategies for crop protection: A review
title_full Recent progress on nanocarriers for Topical-Mediated RNAi Strategies for crop protection: A review
title_fullStr Recent progress on nanocarriers for Topical-Mediated RNAi Strategies for crop protection: A review
title_full_unstemmed Recent progress on nanocarriers for Topical-Mediated RNAi Strategies for crop protection: A review
title_sort recent progress on nanocarriers for topical-mediated rnai strategies for crop protection: a review
publisher MDPI
publishDate 2023
url http://eprints.um.edu.my/38509/
_version_ 1806442651484946432
score 13.211869

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