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Recent advancements in polymer matrix nanocomposites for bone tissue engineering applications

Several polymer-based nanocomposites have been studied and used for tissue engineering applications in recent years. These biodegradable nanocomposites have proven advantageous for bone tissue cultivation and produc-tion. Materials such as polymers, metals, and ceramics are commonly used to fabricat...

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Main Authors:	Sagadevan, Suresh, Schirhagl, Romana, Rahman, Md Zillur, Ismail, Muhamad Fareez Bin, Lett, J. Anita, Fatimah, Is, Kaus, Noor Haida Mohd, Oh, Won-Chun
Format:	Article
Published:	Elsevier 2023
Subjects:	Q Science (General) Medical technology T Technology (General)
Online Access:	http://eprints.um.edu.my/38469/
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spelling	my.um.eprints.384692024-11-10T04:39:00Z http://eprints.um.edu.my/38469/ Recent advancements in polymer matrix nanocomposites for bone tissue engineering applications Sagadevan, Suresh Schirhagl, Romana Rahman, Md Zillur Ismail, Muhamad Fareez Bin Lett, J. Anita Fatimah, Is Kaus, Noor Haida Mohd Oh, Won-Chun Q Science (General) Medical technology T Technology (General) Several polymer-based nanocomposites have been studied and used for tissue engineering applications in recent years. These biodegradable nanocomposites have proven advantageous for bone tissue cultivation and produc-tion. Materials such as polymers, metals, and ceramics are commonly used to fabricate biomaterials. Although some polymeric materials are biodegradable and bioactive in bone tissue engineering applications, they do not match the strength of the bone. On the other hand, metals come in various shapes and sizes, including screws, pins, plates, and stents. These metallic implants are mechanically strong and can temporarily support bones, joints, and teeth. They are neither absorbed/resorbed by the body nor transformed into bone. With metal im-plants, there is also a possibility of infection and secondary operations. In contrast, polymer nanocomposites have bioinertness, low chemical reactivity, biocompatibility, osseointegration, regeneration, and deposition of mineral components capability. They can mimic bones, joints, and teeth in orthopedic applications to repair and replace damaged or diseased tissues. This study reviews current research on bone regeneration technology and potential treatment options for bone tissue regeneration in specific bone abnormalities with nanocomposites. The incorporation of growth factors into nanocomposite scaffolds for osteogenesis and bone remodeling is also discussed. Elsevier 2023-04 Article PeerReviewed Sagadevan, Suresh and Schirhagl, Romana and Rahman, Md Zillur and Ismail, Muhamad Fareez Bin and Lett, J. Anita and Fatimah, Is and Kaus, Noor Haida Mohd and Oh, Won-Chun (2023) Recent advancements in polymer matrix nanocomposites for bone tissue engineering applications. Journal of Drug Delivery Science and Technology, 82. ISSN 1773-2247, DOI https://doi.org/10.1016/j.jddst.2023.104313 <https://doi.org/10.1016/j.jddst.2023.104313>. 10.1016/j.jddst.2023.104313
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	Q Science (General) Medical technology T Technology (General)
spellingShingle	Q Science (General) Medical technology T Technology (General) Sagadevan, Suresh Schirhagl, Romana Rahman, Md Zillur Ismail, Muhamad Fareez Bin Lett, J. Anita Fatimah, Is Kaus, Noor Haida Mohd Oh, Won-Chun Recent advancements in polymer matrix nanocomposites for bone tissue engineering applications
description	Several polymer-based nanocomposites have been studied and used for tissue engineering applications in recent years. These biodegradable nanocomposites have proven advantageous for bone tissue cultivation and produc-tion. Materials such as polymers, metals, and ceramics are commonly used to fabricate biomaterials. Although some polymeric materials are biodegradable and bioactive in bone tissue engineering applications, they do not match the strength of the bone. On the other hand, metals come in various shapes and sizes, including screws, pins, plates, and stents. These metallic implants are mechanically strong and can temporarily support bones, joints, and teeth. They are neither absorbed/resorbed by the body nor transformed into bone. With metal im-plants, there is also a possibility of infection and secondary operations. In contrast, polymer nanocomposites have bioinertness, low chemical reactivity, biocompatibility, osseointegration, regeneration, and deposition of mineral components capability. They can mimic bones, joints, and teeth in orthopedic applications to repair and replace damaged or diseased tissues. This study reviews current research on bone regeneration technology and potential treatment options for bone tissue regeneration in specific bone abnormalities with nanocomposites. The incorporation of growth factors into nanocomposite scaffolds for osteogenesis and bone remodeling is also discussed.
format	Article
author	Sagadevan, Suresh Schirhagl, Romana Rahman, Md Zillur Ismail, Muhamad Fareez Bin Lett, J. Anita Fatimah, Is Kaus, Noor Haida Mohd Oh, Won-Chun
author_facet	Sagadevan, Suresh Schirhagl, Romana Rahman, Md Zillur Ismail, Muhamad Fareez Bin Lett, J. Anita Fatimah, Is Kaus, Noor Haida Mohd Oh, Won-Chun
author_sort	Sagadevan, Suresh
title	Recent advancements in polymer matrix nanocomposites for bone tissue engineering applications
title_short	Recent advancements in polymer matrix nanocomposites for bone tissue engineering applications
title_full	Recent advancements in polymer matrix nanocomposites for bone tissue engineering applications
title_fullStr	Recent advancements in polymer matrix nanocomposites for bone tissue engineering applications
title_full_unstemmed	Recent advancements in polymer matrix nanocomposites for bone tissue engineering applications
title_sort	recent advancements in polymer matrix nanocomposites for bone tissue engineering applications
publisher	Elsevier
publishDate	2023
url	http://eprints.um.edu.my/38469/
_version_	1816130399894503424
score	13.223943

Recent advancements in polymer matrix nanocomposites for bone tissue engineering applications

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