Staff View: Red palm olein-enriched biscuit supplementation lowers Ascaris lumbricoides reinfection at 6-month after anthelmintic treatment among schoolchildren with vitamin A deficiency (VAD)

Red palm olein-enriched biscuit supplementation lowers Ascaris lumbricoides reinfection at 6-month after anthelmintic treatment among schoolchildren with vitamin A deficiency (VAD)

Notwithstanding the global efforts made to control intestinal parasitic infections, soil-transmitted helminth (STH) infections are still one of the most prevalent infections globally, especially in developing countries. A double-blinded, randomized controlled trial was conducted on 343 primary schoo...

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Main Authors:	Tan, Pei Yee, Loganathan, Radhika, Teng, Kim-Tiu, Lee, Soo Ching, Johari, Syahirah Nadiah Mohd, Selvaduray, Kanga Rani, Ngui, Romano, Lim, Yvonne Ai-Lian
Format:	Article
Published:	Elsevier 2023
Subjects:	RM Therapeutics. Pharmacology RS Pharmacy and materia medica Diseases, treatment, etc
Online Access:	http://eprints.um.edu.my/38377/
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spelling	my.um.eprints.383772024-11-27T03:53:43Z http://eprints.um.edu.my/38377/ Red palm olein-enriched biscuit supplementation lowers Ascaris lumbricoides reinfection at 6-month after anthelmintic treatment among schoolchildren with vitamin A deficiency (VAD) Tan, Pei Yee Loganathan, Radhika Teng, Kim-Tiu Lee, Soo Ching Johari, Syahirah Nadiah Mohd Selvaduray, Kanga Rani Ngui, Romano Lim, Yvonne Ai-Lian RM Therapeutics. Pharmacology RS Pharmacy and materia medica Diseases, treatment, etc Notwithstanding the global efforts made to control intestinal parasitic infections, soil-transmitted helminth (STH) infections are still one of the most prevalent infections globally, especially in developing countries. A double-blinded, randomized controlled trial was conducted on 343 primary schoolchildren (8-12 years old) with vitamin A deficiency (VAD) in rural areas of Malaysia to investigate the effects of red palm olein (RPO)-enriched biscuits on STH reinfection rates and infection intensities. The effects of the RPO-enriched biscuits (experimental group, n = 153) and palm olein (PO)-enriched biscuits (control group, n = 190), were assessed at 3-and 6-month after the administration of complete triple-dose albendazole (one dose of 400 mg for three consecutive days). The overall STH infection rate at baseline was recorded at 65.6%. At 6-month, a significantly lower reinfection rate of A. lumbricoides was observed in the experimental group (35.3%) compared to the control group (60.0%) (P< 0.05), and a significant reduction in fecal egg count (epg) of A. lumbricoides was observed in the experimental group from baseline (P< 0.001), but no significant reduction was observed in the control group. No significant differences in the reduction of infection intensities of T. trichiura and hookworm were observed between experimental and control groups at 3-and 6-month (P>0.05). These findings suggest the potential beneficial effects of RPO-enriched biscuit supplementation on the reinfection of A. lumbricoides, which could be attributed to its high carotenoids content by enhancing host immune response and mucosal epithelium integrity. However, further studies are warranted to confirm whether RPO supplementation could result in similar parasite-specific beneficial effects in other community settings, as well as to explore the underlying mechanisms. Elsevier 2023-04 Article PeerReviewed Tan, Pei Yee and Loganathan, Radhika and Teng, Kim-Tiu and Lee, Soo Ching and Johari, Syahirah Nadiah Mohd and Selvaduray, Kanga Rani and Ngui, Romano and Lim, Yvonne Ai-Lian (2023) Red palm olein-enriched biscuit supplementation lowers Ascaris lumbricoides reinfection at 6-month after anthelmintic treatment among schoolchildren with vitamin A deficiency (VAD). Acta Tropica, 240. ISSN 0001-706X, DOI https://doi.org/10.1016/j.actatropica.2023.106860 <https://doi.org/10.1016/j.actatropica.2023.106860>. 10.1016/j.actatropica.2023.106860
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	RM Therapeutics. Pharmacology RS Pharmacy and materia medica Diseases, treatment, etc
spellingShingle	RM Therapeutics. Pharmacology RS Pharmacy and materia medica Diseases, treatment, etc Tan, Pei Yee Loganathan, Radhika Teng, Kim-Tiu Lee, Soo Ching Johari, Syahirah Nadiah Mohd Selvaduray, Kanga Rani Ngui, Romano Lim, Yvonne Ai-Lian Red palm olein-enriched biscuit supplementation lowers Ascaris lumbricoides reinfection at 6-month after anthelmintic treatment among schoolchildren with vitamin A deficiency (VAD)
description	Notwithstanding the global efforts made to control intestinal parasitic infections, soil-transmitted helminth (STH) infections are still one of the most prevalent infections globally, especially in developing countries. A double-blinded, randomized controlled trial was conducted on 343 primary schoolchildren (8-12 years old) with vitamin A deficiency (VAD) in rural areas of Malaysia to investigate the effects of red palm olein (RPO)-enriched biscuits on STH reinfection rates and infection intensities. The effects of the RPO-enriched biscuits (experimental group, n = 153) and palm olein (PO)-enriched biscuits (control group, n = 190), were assessed at 3-and 6-month after the administration of complete triple-dose albendazole (one dose of 400 mg for three consecutive days). The overall STH infection rate at baseline was recorded at 65.6%. At 6-month, a significantly lower reinfection rate of A. lumbricoides was observed in the experimental group (35.3%) compared to the control group (60.0%) (P< 0.05), and a significant reduction in fecal egg count (epg) of A. lumbricoides was observed in the experimental group from baseline (P< 0.001), but no significant reduction was observed in the control group. No significant differences in the reduction of infection intensities of T. trichiura and hookworm were observed between experimental and control groups at 3-and 6-month (P>0.05). These findings suggest the potential beneficial effects of RPO-enriched biscuit supplementation on the reinfection of A. lumbricoides, which could be attributed to its high carotenoids content by enhancing host immune response and mucosal epithelium integrity. However, further studies are warranted to confirm whether RPO supplementation could result in similar parasite-specific beneficial effects in other community settings, as well as to explore the underlying mechanisms.
format	Article
author	Tan, Pei Yee Loganathan, Radhika Teng, Kim-Tiu Lee, Soo Ching Johari, Syahirah Nadiah Mohd Selvaduray, Kanga Rani Ngui, Romano Lim, Yvonne Ai-Lian
author_facet	Tan, Pei Yee Loganathan, Radhika Teng, Kim-Tiu Lee, Soo Ching Johari, Syahirah Nadiah Mohd Selvaduray, Kanga Rani Ngui, Romano Lim, Yvonne Ai-Lian
author_sort	Tan, Pei Yee
title	Red palm olein-enriched biscuit supplementation lowers Ascaris lumbricoides reinfection at 6-month after anthelmintic treatment among schoolchildren with vitamin A deficiency (VAD)
title_short	Red palm olein-enriched biscuit supplementation lowers Ascaris lumbricoides reinfection at 6-month after anthelmintic treatment among schoolchildren with vitamin A deficiency (VAD)
title_full	Red palm olein-enriched biscuit supplementation lowers Ascaris lumbricoides reinfection at 6-month after anthelmintic treatment among schoolchildren with vitamin A deficiency (VAD)
title_fullStr	Red palm olein-enriched biscuit supplementation lowers Ascaris lumbricoides reinfection at 6-month after anthelmintic treatment among schoolchildren with vitamin A deficiency (VAD)
title_full_unstemmed	Red palm olein-enriched biscuit supplementation lowers Ascaris lumbricoides reinfection at 6-month after anthelmintic treatment among schoolchildren with vitamin A deficiency (VAD)
title_sort	red palm olein-enriched biscuit supplementation lowers ascaris lumbricoides reinfection at 6-month after anthelmintic treatment among schoolchildren with vitamin a deficiency (vad)
publisher	Elsevier
publishDate	2023
url	http://eprints.um.edu.my/38377/
_version_	1817841935008661504
score	13.239859

Red palm olein-enriched biscuit supplementation lowers Ascaris lumbricoides reinfection at 6-month after anthelmintic treatment among schoolchildren with vitamin A deficiency (VAD)

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