Staff View: Small extracellular vesicles' miRNAs: Biomarkers and therapeutics for neurodegenerative diseases

Small extracellular vesicles' miRNAs: Biomarkers and therapeutics for neurodegenerative diseases

Neurodegenerative diseases are critical in the healthcare system as patients suffer from progressive diseases despite currently available drug management. Indeed, the growing ageing population will burden the country's healthcare system and the caretakers. Thus, there is a need for new manageme...

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Main Authors:	Lim, Wei Qing, Luk, Kie Hoon Michelle, Lee, Kah Yee, Nurul, Nasuha, Loh, Sin Jade, Yeow, Zhen Xiong, Wong, Qi Xuan, Looi, Qi Hao Daniel, Chong, Pan Pan, How, Chee Wun, Hamzah, Sharina, Foo, Jhi Biau
Format:	Article
Published:	Multidisciplinary Digital Publishing Institute (MDPI) 2023
Subjects:	R Medicine RM Therapeutics. Pharmacology
Online Access:	http://eprints.um.edu.my/38349/
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id	my.um.eprints.38349
record_format	eprints
spelling	my.um.eprints.383492024-11-08T02:56:47Z http://eprints.um.edu.my/38349/ Small extracellular vesicles' miRNAs: Biomarkers and therapeutics for neurodegenerative diseases Lim, Wei Qing Luk, Kie Hoon Michelle Lee, Kah Yee Nurul, Nasuha Loh, Sin Jade Yeow, Zhen Xiong Wong, Qi Xuan Looi, Qi Hao Daniel Chong, Pan Pan How, Chee Wun Hamzah, Sharina Foo, Jhi Biau R Medicine RM Therapeutics. Pharmacology Neurodegenerative diseases are critical in the healthcare system as patients suffer from progressive diseases despite currently available drug management. Indeed, the growing ageing population will burden the country's healthcare system and the caretakers. Thus, there is a need for new management that could stop or reverse the progression of neurodegenerative diseases. Stem cells possess a remarkable regenerative potential that has long been investigated to resolve these issues. Some breakthroughs have been achieved thus far to replace the damaged brain cells; however, the procedure's invasiveness has prompted scientists to investigate using stem-cell small extracellular vesicles (sEVs) as a non-invasive cell-free therapy to address the limitations of cell therapy. With the advancement of technology to understand the molecular changes of neurodegenerative diseases, efforts have been made to enrich stem cells' sEVs with miRNAs to increase the therapeutic efficacy of the sEVs. In this article, the pathophysiology of various neurodegenerative diseases is highlighted. The role of miRNAs from sEVs as biomarkers and treatments is also discussed. Lastly, the applications and delivery of stem cells and their miRNA-enriched sEVs for treating neurodegenerative diseases are emphasised and reviewed. Multidisciplinary Digital Publishing Institute (MDPI) 2023-04 Article PeerReviewed Lim, Wei Qing and Luk, Kie Hoon Michelle and Lee, Kah Yee and Nurul, Nasuha and Loh, Sin Jade and Yeow, Zhen Xiong and Wong, Qi Xuan and Looi, Qi Hao Daniel and Chong, Pan Pan and How, Chee Wun and Hamzah, Sharina and Foo, Jhi Biau (2023) Small extracellular vesicles' miRNAs: Biomarkers and therapeutics for neurodegenerative diseases. PHARMACEUTICS, 15 (4). ISSN 19994923, DOI https://doi.org/10.3390/pharmaceutics15041216 <https://doi.org/10.3390/pharmaceutics15041216>. 10.3390/pharmaceutics15041216
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	R Medicine RM Therapeutics. Pharmacology
spellingShingle	R Medicine RM Therapeutics. Pharmacology Lim, Wei Qing Luk, Kie Hoon Michelle Lee, Kah Yee Nurul, Nasuha Loh, Sin Jade Yeow, Zhen Xiong Wong, Qi Xuan Looi, Qi Hao Daniel Chong, Pan Pan How, Chee Wun Hamzah, Sharina Foo, Jhi Biau Small extracellular vesicles' miRNAs: Biomarkers and therapeutics for neurodegenerative diseases
description	Neurodegenerative diseases are critical in the healthcare system as patients suffer from progressive diseases despite currently available drug management. Indeed, the growing ageing population will burden the country's healthcare system and the caretakers. Thus, there is a need for new management that could stop or reverse the progression of neurodegenerative diseases. Stem cells possess a remarkable regenerative potential that has long been investigated to resolve these issues. Some breakthroughs have been achieved thus far to replace the damaged brain cells; however, the procedure's invasiveness has prompted scientists to investigate using stem-cell small extracellular vesicles (sEVs) as a non-invasive cell-free therapy to address the limitations of cell therapy. With the advancement of technology to understand the molecular changes of neurodegenerative diseases, efforts have been made to enrich stem cells' sEVs with miRNAs to increase the therapeutic efficacy of the sEVs. In this article, the pathophysiology of various neurodegenerative diseases is highlighted. The role of miRNAs from sEVs as biomarkers and treatments is also discussed. Lastly, the applications and delivery of stem cells and their miRNA-enriched sEVs for treating neurodegenerative diseases are emphasised and reviewed.
format	Article
author	Lim, Wei Qing Luk, Kie Hoon Michelle Lee, Kah Yee Nurul, Nasuha Loh, Sin Jade Yeow, Zhen Xiong Wong, Qi Xuan Looi, Qi Hao Daniel Chong, Pan Pan How, Chee Wun Hamzah, Sharina Foo, Jhi Biau
author_facet	Lim, Wei Qing Luk, Kie Hoon Michelle Lee, Kah Yee Nurul, Nasuha Loh, Sin Jade Yeow, Zhen Xiong Wong, Qi Xuan Looi, Qi Hao Daniel Chong, Pan Pan How, Chee Wun Hamzah, Sharina Foo, Jhi Biau
author_sort	Lim, Wei Qing
title	Small extracellular vesicles' miRNAs: Biomarkers and therapeutics for neurodegenerative diseases
title_short	Small extracellular vesicles' miRNAs: Biomarkers and therapeutics for neurodegenerative diseases
title_full	Small extracellular vesicles' miRNAs: Biomarkers and therapeutics for neurodegenerative diseases
title_fullStr	Small extracellular vesicles' miRNAs: Biomarkers and therapeutics for neurodegenerative diseases
title_full_unstemmed	Small extracellular vesicles' miRNAs: Biomarkers and therapeutics for neurodegenerative diseases
title_sort	small extracellular vesicles' mirnas: biomarkers and therapeutics for neurodegenerative diseases
publisher	Multidisciplinary Digital Publishing Institute (MDPI)
publishDate	2023
url	http://eprints.um.edu.my/38349/
_version_	1816130394327613440
score	13.226497

Small extracellular vesicles' miRNAs: Biomarkers and therapeutics for neurodegenerative diseases

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