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Distribution of causative microorganisms in diabetic foot infections: A ten-year retrospective study in a tertiary care hospital in central Malaysia

Diabetes mellitus is a global pandemic, especially in Southeast Asia. Diabetic foot infection (DFI) is a common complication of this condition and causes significant morbidity and mortality in those affected. There is a lack of locally published data on the types of microorganisms and empirical anti...

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Main Authors: Hadi, Parichehr, Rampal, Sanjiv, Neela, Vasantha Kumari, Cheema, Manraj Singh, Singh, Sandeep Singh Sarawan, Tan, Eng Kee, Sinniah, Ajantha
Format: Article
Published: MDPI 2023
Subjects:
RB Pathology
RS Pharmacy and materia medica
Online Access:http://eprints.um.edu.my/38337/
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spelling my.um.eprints.383372023-11-27T07:49:33Z http://eprints.um.edu.my/38337/ Distribution of causative microorganisms in diabetic foot infections: A ten-year retrospective study in a tertiary care hospital in central Malaysia Hadi, Parichehr Rampal, Sanjiv Neela, Vasantha Kumari Cheema, Manraj Singh Singh, Sandeep Singh Sarawan Tan, Eng Kee Sinniah, Ajantha RB Pathology RS Pharmacy and materia medica Diabetes mellitus is a global pandemic, especially in Southeast Asia. Diabetic foot infection (DFI) is a common complication of this condition and causes significant morbidity and mortality in those affected. There is a lack of locally published data on the types of microorganisms and empirical antibiotics being prescribed. This paper highlights the importance of local microorganism culture and antibiotic prescription trends among diabetic foot patients in a tertiary care hospital in central Malaysia. This is a retrospective, cross-sectional study of data taken from January 2010 to December 2019 among 434 patients admitted with diabetic foot infections (DFIs) using the Wagner classification. Patients between the ages of 58 and 68 years old had the highest rate of infection. Pseudomonas Aeruginosa, Proteus spp., and Proteus mirabilis appeared to be the most isolated Gram-negative microorganisms, and Staphylococcus aureus, Streptococcus agalactiae, and MRSA appeared to be the most common Gram-positive microorganisms. The most common empirical antibiotics prescribed were ampicillin/sulbactam, followed by ciprofloxacin and ceftazidime, and the most common therapeutic antibiotics prescribed were ampicillin/sulbactam, ciprofloxacin, and cefuroxime. This study could be immensely pertinent in facilitating future empirical therapy guidelines for treating diabetic foot infections. MDPI 2023-04 Article PeerReviewed Hadi, Parichehr and Rampal, Sanjiv and Neela, Vasantha Kumari and Cheema, Manraj Singh and Singh, Sandeep Singh Sarawan and Tan, Eng Kee and Sinniah, Ajantha (2023) Distribution of causative microorganisms in diabetic foot infections: A ten-year retrospective study in a tertiary care hospital in central Malaysia. Antibiotics-Basel, 12 (4). ISSN 2079-6382, DOI https://doi.org/10.3390/antibiotics12040687 <https://doi.org/10.3390/antibiotics12040687>. 10.3390/antibiotics12040687
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic RB Pathology
RS Pharmacy and materia medica
spellingShingle RB Pathology
RS Pharmacy and materia medica
Hadi, Parichehr
Rampal, Sanjiv
Neela, Vasantha Kumari
Cheema, Manraj Singh
Singh, Sandeep Singh Sarawan
Tan, Eng Kee
Sinniah, Ajantha
Distribution of causative microorganisms in diabetic foot infections: A ten-year retrospective study in a tertiary care hospital in central Malaysia
description Diabetes mellitus is a global pandemic, especially in Southeast Asia. Diabetic foot infection (DFI) is a common complication of this condition and causes significant morbidity and mortality in those affected. There is a lack of locally published data on the types of microorganisms and empirical antibiotics being prescribed. This paper highlights the importance of local microorganism culture and antibiotic prescription trends among diabetic foot patients in a tertiary care hospital in central Malaysia. This is a retrospective, cross-sectional study of data taken from January 2010 to December 2019 among 434 patients admitted with diabetic foot infections (DFIs) using the Wagner classification. Patients between the ages of 58 and 68 years old had the highest rate of infection. Pseudomonas Aeruginosa, Proteus spp., and Proteus mirabilis appeared to be the most isolated Gram-negative microorganisms, and Staphylococcus aureus, Streptococcus agalactiae, and MRSA appeared to be the most common Gram-positive microorganisms. The most common empirical antibiotics prescribed were ampicillin/sulbactam, followed by ciprofloxacin and ceftazidime, and the most common therapeutic antibiotics prescribed were ampicillin/sulbactam, ciprofloxacin, and cefuroxime. This study could be immensely pertinent in facilitating future empirical therapy guidelines for treating diabetic foot infections.
format Article
author Hadi, Parichehr
Rampal, Sanjiv
Neela, Vasantha Kumari
Cheema, Manraj Singh
Singh, Sandeep Singh Sarawan
Tan, Eng Kee
Sinniah, Ajantha
author_facet Hadi, Parichehr
Rampal, Sanjiv
Neela, Vasantha Kumari
Cheema, Manraj Singh
Singh, Sandeep Singh Sarawan
Tan, Eng Kee
Sinniah, Ajantha
author_sort Hadi, Parichehr
title Distribution of causative microorganisms in diabetic foot infections: A ten-year retrospective study in a tertiary care hospital in central Malaysia
title_short Distribution of causative microorganisms in diabetic foot infections: A ten-year retrospective study in a tertiary care hospital in central Malaysia
title_full Distribution of causative microorganisms in diabetic foot infections: A ten-year retrospective study in a tertiary care hospital in central Malaysia
title_fullStr Distribution of causative microorganisms in diabetic foot infections: A ten-year retrospective study in a tertiary care hospital in central Malaysia
title_full_unstemmed Distribution of causative microorganisms in diabetic foot infections: A ten-year retrospective study in a tertiary care hospital in central Malaysia
title_sort distribution of causative microorganisms in diabetic foot infections: a ten-year retrospective study in a tertiary care hospital in central malaysia
publisher MDPI
publishDate 2023
url http://eprints.um.edu.my/38337/
_version_ 1783876662382821376
score 13.211869

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