Designing of 2,3-dihydrobenzofuran derivatives as inhibitors of PDE1B using pharmacophore screening, ensemble docking and molecular dynamics approach
In recent years, the PDE1B enzyme has become a desirable drug target for the treatment of psychological and neurological disorders, particularly schizophrenia disorder, due to the expression of PDE1B in brain regions involved in volitional behaviour, learning and memory. Although several inhibitors...
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| Main Authors: | , , |
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| Format: | Article |
| Published: |
Elsevier
2023
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/38284/ |
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