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Hepatoprotective Effects of Panus giganteus (Berk.) Corner against Thioacetamide- (TAA-) Induced Liver Injury in Rats

Panus giganteus, a culinary and medicinal mushroom consumed by selected indigenous communities in Malaysia, is currently being considered for large scale cultivation. This study was undertaken to investigate the hepatoprotective effects of P. giganteus against thioacetamide- (TAA-) induced liver inj...

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Main Authors: Wong, Wei Lun, Abdulla, Mahmood Ameen, Chua, Kek Heng, Kuppusamy, Umah Rani, Tan, Yee Shin, Sabaratnam, Vikineswary
Format: Article
Language:English
Published: Hindawi 2012
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/3818/1/Hepatoprotective_effects_of_Panus_giganteus_%28Berk.%29_Corner_against_thioacetamide_%28TAA%29-_induced_liver_injury_in_rats..pdf
http://eprints.um.edu.my/3818/
http://dx.doi.org/10.1155/2012/170303
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spelling my.um.eprints.38182019-11-22T02:43:48Z http://eprints.um.edu.my/3818/ Hepatoprotective Effects of Panus giganteus (Berk.) Corner against Thioacetamide- (TAA-) Induced Liver Injury in Rats Wong, Wei Lun Abdulla, Mahmood Ameen Chua, Kek Heng Kuppusamy, Umah Rani Tan, Yee Shin Sabaratnam, Vikineswary R Medicine Panus giganteus, a culinary and medicinal mushroom consumed by selected indigenous communities in Malaysia, is currently being considered for large scale cultivation. This study was undertaken to investigate the hepatoprotective effects of P. giganteus against thioacetamide- (TAA-) induced liver injury in Sprague-Dawley rats. The rats were injected intraperitoneally with TAA thrice weekly and were orally administered freeze-dried fruiting bodies of P. giganteus (0.5 or 1 g/kg) daily for two months, while control rats were given vehicle or P. giganteus only. After 60 days, rats administered with P. giganteus showed lower liver body weight ratio, restored levels of serum liver biomarkers and oxidative stress parameters comparable to treatment with the standard drug silymarin. Gross necropsy and histopathological examination further confirmed the hepatoprotective effects of P. giganteus. This is the first report on hepatoprotective effects of P. giganteus. The present study showed that P. giganteus was able to prevent or reduce the severity of TAA-induced liver injury. Hindawi 2012 Article PeerReviewed application/pdf en http://eprints.um.edu.my/3818/1/Hepatoprotective_effects_of_Panus_giganteus_%28Berk.%29_Corner_against_thioacetamide_%28TAA%29-_induced_liver_injury_in_rats..pdf Wong, Wei Lun and Abdulla, Mahmood Ameen and Chua, Kek Heng and Kuppusamy, Umah Rani and Tan, Yee Shin and Sabaratnam, Vikineswary (2012) Hepatoprotective Effects of Panus giganteus (Berk.) Corner against Thioacetamide- (TAA-) Induced Liver Injury in Rats. Evidence-Based Complementary and Alternative Medicine, 2012. p. 170303. ISSN 1741-427X http://dx.doi.org/10.1155/2012/170303 doi:10.1155/2012/170303
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
language English
topic R Medicine
spellingShingle R Medicine
Wong, Wei Lun
Abdulla, Mahmood Ameen
Chua, Kek Heng
Kuppusamy, Umah Rani
Tan, Yee Shin
Sabaratnam, Vikineswary
Hepatoprotective Effects of Panus giganteus (Berk.) Corner against Thioacetamide- (TAA-) Induced Liver Injury in Rats
description Panus giganteus, a culinary and medicinal mushroom consumed by selected indigenous communities in Malaysia, is currently being considered for large scale cultivation. This study was undertaken to investigate the hepatoprotective effects of P. giganteus against thioacetamide- (TAA-) induced liver injury in Sprague-Dawley rats. The rats were injected intraperitoneally with TAA thrice weekly and were orally administered freeze-dried fruiting bodies of P. giganteus (0.5 or 1 g/kg) daily for two months, while control rats were given vehicle or P. giganteus only. After 60 days, rats administered with P. giganteus showed lower liver body weight ratio, restored levels of serum liver biomarkers and oxidative stress parameters comparable to treatment with the standard drug silymarin. Gross necropsy and histopathological examination further confirmed the hepatoprotective effects of P. giganteus. This is the first report on hepatoprotective effects of P. giganteus. The present study showed that P. giganteus was able to prevent or reduce the severity of TAA-induced liver injury.
format Article
author Wong, Wei Lun
Abdulla, Mahmood Ameen
Chua, Kek Heng
Kuppusamy, Umah Rani
Tan, Yee Shin
Sabaratnam, Vikineswary
author_facet Wong, Wei Lun
Abdulla, Mahmood Ameen
Chua, Kek Heng
Kuppusamy, Umah Rani
Tan, Yee Shin
Sabaratnam, Vikineswary
author_sort Wong, Wei Lun
title Hepatoprotective Effects of Panus giganteus (Berk.) Corner against Thioacetamide- (TAA-) Induced Liver Injury in Rats
title_short Hepatoprotective Effects of Panus giganteus (Berk.) Corner against Thioacetamide- (TAA-) Induced Liver Injury in Rats
title_full Hepatoprotective Effects of Panus giganteus (Berk.) Corner against Thioacetamide- (TAA-) Induced Liver Injury in Rats
title_fullStr Hepatoprotective Effects of Panus giganteus (Berk.) Corner against Thioacetamide- (TAA-) Induced Liver Injury in Rats
title_full_unstemmed Hepatoprotective Effects of Panus giganteus (Berk.) Corner against Thioacetamide- (TAA-) Induced Liver Injury in Rats
title_sort hepatoprotective effects of panus giganteus (berk.) corner against thioacetamide- (taa-) induced liver injury in rats
publisher Hindawi
publishDate 2012
url http://eprints.um.edu.my/3818/1/Hepatoprotective_effects_of_Panus_giganteus_%28Berk.%29_Corner_against_thioacetamide_%28TAA%29-_induced_liver_injury_in_rats..pdf
http://eprints.um.edu.my/3818/
http://dx.doi.org/10.1155/2012/170303
_version_ 1651867317287518208
score 13.222552

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