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Acceptability of bisphosphonates among patients, clinicians and managers: A systematic review and framework synthesis

Objective To explore the acceptability of different bisphosphonate regimens for the treatment of osteoporosis among patients, clinicians and managers, payers and academics. Design A systematic review of primary qualitative studies. Seven databases were searched from inception to July 2019. Screening...

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Main Authors:	Paskins, Zoe, Crawford-Manning, Fay, Cottrell, Elizabeth, Corp, Nadia, Wright, Jenny, Jinks, Clare, Bishop, Simon, Doyle, Alison, Ong, Terence, Gittoes, Neil, Leonardi-Bee, Jo, Langley, Tessa, Horne, Robert, Sahota, Opinder
Format:	Article
Published:	BMJ Publishing Group 2020
Subjects:	R Medicine (General)
Online Access:	http://eprints.um.edu.my/38086/
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spelling	my.um.eprints.380862023-01-16T07:30:38Z http://eprints.um.edu.my/38086/ Acceptability of bisphosphonates among patients, clinicians and managers: A systematic review and framework synthesis Paskins, Zoe Crawford-Manning, Fay Cottrell, Elizabeth Corp, Nadia Wright, Jenny Jinks, Clare Bishop, Simon Doyle, Alison Ong, Terence Gittoes, Neil Leonardi-Bee, Jo Langley, Tessa Horne, Robert Sahota, Opinder R Medicine (General) Objective To explore the acceptability of different bisphosphonate regimens for the treatment of osteoporosis among patients, clinicians and managers, payers and academics. Design A systematic review of primary qualitative studies. Seven databases were searched from inception to July 2019. Screening, data extraction and quality assessment of full-articles selected for inclusion were performed independently by two authors. A framework synthesis was applied to extracted data based on the theoretical framework of acceptability (TFA). The TFA includes seven domains relating to sense-making, emotions, opportunity costs, burden, perceived effectiveness, ethicality and self-efficacy. Confidence in synthesis findings was assessed. Setting Any developed country healthcare setting. Participants Patients, healthcare professionals, managers, payers and academics. Intervention Experiences and views of oral and intravenous bisphosphonates. Results Twenty-five studies were included, mostly describing perceptions of oral bisphosphonates. We identified, with high confidence, how patients and healthcare professionals make sense (coherence) of bisphosphonates by balancing perceptions of need against concerns, how uncertainty prevails about bisphosphonate perceived effectiveness and a number of individual and service factors that have potential to increase self-efficacy in recommending and adhering to bisphosphonates. We identified, with moderate confidence, that bisphosphonate taking induces concern, but has the potential to engender reassurance, and that both side effects and special instructions for taking oral bisphosphonates can result in treatment burden. Finally, we identified with low confidence that multimorbidity plays a role in people's perception of bisphosphonate acceptability. Conclusion By using the lens of acceptability, our findings demonstrate with high confidence that a theoretically informed, whole-system approach is necessary to both understand and improve adherence. Clinicians and patients need supporting to understand the need for bisphosphonates, and clinicians need to clarify to patients what constitutes bisphosphonate treatment success. Further research is needed to explore perspectives of male patients and those with multimorbidity receiving bisphosphonates, and patients receiving intravenous treatment. BMJ Publishing Group 2020 Article PeerReviewed Paskins, Zoe and Crawford-Manning, Fay and Cottrell, Elizabeth and Corp, Nadia and Wright, Jenny and Jinks, Clare and Bishop, Simon and Doyle, Alison and Ong, Terence and Gittoes, Neil and Leonardi-Bee, Jo and Langley, Tessa and Horne, Robert and Sahota, Opinder (2020) Acceptability of bisphosphonates among patients, clinicians and managers: A systematic review and framework synthesis. BMJ Open, 10 (11). ISSN 2044-6055, DOI https://doi.org/10.1136/bmjopen-2020-040634 <https://doi.org/10.1136/bmjopen-2020-040634>. 10.1136/bmjopen-2020-040634
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	R Medicine (General)
spellingShingle	R Medicine (General) Paskins, Zoe Crawford-Manning, Fay Cottrell, Elizabeth Corp, Nadia Wright, Jenny Jinks, Clare Bishop, Simon Doyle, Alison Ong, Terence Gittoes, Neil Leonardi-Bee, Jo Langley, Tessa Horne, Robert Sahota, Opinder Acceptability of bisphosphonates among patients, clinicians and managers: A systematic review and framework synthesis
description	Objective To explore the acceptability of different bisphosphonate regimens for the treatment of osteoporosis among patients, clinicians and managers, payers and academics. Design A systematic review of primary qualitative studies. Seven databases were searched from inception to July 2019. Screening, data extraction and quality assessment of full-articles selected for inclusion were performed independently by two authors. A framework synthesis was applied to extracted data based on the theoretical framework of acceptability (TFA). The TFA includes seven domains relating to sense-making, emotions, opportunity costs, burden, perceived effectiveness, ethicality and self-efficacy. Confidence in synthesis findings was assessed. Setting Any developed country healthcare setting. Participants Patients, healthcare professionals, managers, payers and academics. Intervention Experiences and views of oral and intravenous bisphosphonates. Results Twenty-five studies were included, mostly describing perceptions of oral bisphosphonates. We identified, with high confidence, how patients and healthcare professionals make sense (coherence) of bisphosphonates by balancing perceptions of need against concerns, how uncertainty prevails about bisphosphonate perceived effectiveness and a number of individual and service factors that have potential to increase self-efficacy in recommending and adhering to bisphosphonates. We identified, with moderate confidence, that bisphosphonate taking induces concern, but has the potential to engender reassurance, and that both side effects and special instructions for taking oral bisphosphonates can result in treatment burden. Finally, we identified with low confidence that multimorbidity plays a role in people's perception of bisphosphonate acceptability. Conclusion By using the lens of acceptability, our findings demonstrate with high confidence that a theoretically informed, whole-system approach is necessary to both understand and improve adherence. Clinicians and patients need supporting to understand the need for bisphosphonates, and clinicians need to clarify to patients what constitutes bisphosphonate treatment success. Further research is needed to explore perspectives of male patients and those with multimorbidity receiving bisphosphonates, and patients receiving intravenous treatment.
format	Article
author	Paskins, Zoe Crawford-Manning, Fay Cottrell, Elizabeth Corp, Nadia Wright, Jenny Jinks, Clare Bishop, Simon Doyle, Alison Ong, Terence Gittoes, Neil Leonardi-Bee, Jo Langley, Tessa Horne, Robert Sahota, Opinder
author_facet	Paskins, Zoe Crawford-Manning, Fay Cottrell, Elizabeth Corp, Nadia Wright, Jenny Jinks, Clare Bishop, Simon Doyle, Alison Ong, Terence Gittoes, Neil Leonardi-Bee, Jo Langley, Tessa Horne, Robert Sahota, Opinder
author_sort	Paskins, Zoe
title	Acceptability of bisphosphonates among patients, clinicians and managers: A systematic review and framework synthesis
title_short	Acceptability of bisphosphonates among patients, clinicians and managers: A systematic review and framework synthesis
title_full	Acceptability of bisphosphonates among patients, clinicians and managers: A systematic review and framework synthesis
title_fullStr	Acceptability of bisphosphonates among patients, clinicians and managers: A systematic review and framework synthesis
title_full_unstemmed	Acceptability of bisphosphonates among patients, clinicians and managers: A systematic review and framework synthesis
title_sort	acceptability of bisphosphonates among patients, clinicians and managers: a systematic review and framework synthesis
publisher	BMJ Publishing Group
publishDate	2020
url	http://eprints.um.edu.my/38086/
_version_	1755872670379933696
score	13.235362

Acceptability of bisphosphonates among patients, clinicians and managers: A systematic review and framework synthesis

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