Staff View: A review of the applications of Raman spectroscopy for breast cancer tissue diagnostic and their histopathological classification of epithelial to mesenchymal transition

A review of the applications of Raman spectroscopy for breast cancer tissue diagnostic and their histopathological classification of epithelial to mesenchymal transition

Breast cancer is one of the leading cancers in women worldwide. Notwithstanding the clear advances being made in treatment, early diagnosis of the disease can certainly be expected to reduce morbidity and mortality. With increasing evidence of the role of epithelial to mesenchymal transition (EMT) i...

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Main Authors:	Sabtu, Siti Norbaini, Sani, S. F. Abdul, Bradley, D. A., Looi, Lai Meng, Osman, Zurina
Format:	Article
Published:	Wiley 2020
Subjects:	R Medicine (General) RB Pathology
Online Access:	http://eprints.um.edu.my/37248/
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spelling	my.um.eprints.372482023-03-09T01:25:55Z http://eprints.um.edu.my/37248/ A review of the applications of Raman spectroscopy for breast cancer tissue diagnostic and their histopathological classification of epithelial to mesenchymal transition Sabtu, Siti Norbaini Sani, S. F. Abdul Bradley, D. A. Looi, Lai Meng Osman, Zurina R Medicine (General) RB Pathology Breast cancer is one of the leading cancers in women worldwide. Notwithstanding the clear advances being made in treatment, early diagnosis of the disease can certainly be expected to reduce morbidity and mortality. With increasing evidence of the role of epithelial to mesenchymal transition (EMT) in tumour progression, early detection of this phenomenon is suggested to be important given that the majority of breast cancer deaths are due to tumour invasion and metastasis. Although histopathology and biomedical imaging techniques continue to be used as standard procedures in breast cancer diagnosis, these techniques have a number of disadvantages, including being time-consuming, the imaging in particular having attendant limited resolution, sensitivity, and specificity, leading to results that are prone to errors in human interpretation. Due to its rapidity and high specificity, Raman spectroscopy has emerged as a diagnostic tool for breast cancer, useful in identifying malignancy of breast cells, correlated with the EMT phenotype, expressed at the molecular level. Detailed biochemical information from tissue biopsies can also be provided from use of this technique. The use of Raman spectroscopy in breast cancer investigations over the past 10 years and more, including in the study of EMT, is reviewed in the present work also listing the corresponding Raman peaks reported in the literature in seeking to better facilitate identification of peaks of interest. Wiley 2020-03 Article PeerReviewed Sabtu, Siti Norbaini and Sani, S. F. Abdul and Bradley, D. A. and Looi, Lai Meng and Osman, Zurina (2020) A review of the applications of Raman spectroscopy for breast cancer tissue diagnostic and their histopathological classification of epithelial to mesenchymal transition. Journal of Raman Spectroscopy, 51 (3). pp. 380-389. ISSN 0377-0486, DOI https://doi.org/10.1002/jrs.5774 <https://doi.org/10.1002/jrs.5774>. 10.1002/jrs.5774
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	R Medicine (General) RB Pathology
spellingShingle	R Medicine (General) RB Pathology Sabtu, Siti Norbaini Sani, S. F. Abdul Bradley, D. A. Looi, Lai Meng Osman, Zurina A review of the applications of Raman spectroscopy for breast cancer tissue diagnostic and their histopathological classification of epithelial to mesenchymal transition
description	Breast cancer is one of the leading cancers in women worldwide. Notwithstanding the clear advances being made in treatment, early diagnosis of the disease can certainly be expected to reduce morbidity and mortality. With increasing evidence of the role of epithelial to mesenchymal transition (EMT) in tumour progression, early detection of this phenomenon is suggested to be important given that the majority of breast cancer deaths are due to tumour invasion and metastasis. Although histopathology and biomedical imaging techniques continue to be used as standard procedures in breast cancer diagnosis, these techniques have a number of disadvantages, including being time-consuming, the imaging in particular having attendant limited resolution, sensitivity, and specificity, leading to results that are prone to errors in human interpretation. Due to its rapidity and high specificity, Raman spectroscopy has emerged as a diagnostic tool for breast cancer, useful in identifying malignancy of breast cells, correlated with the EMT phenotype, expressed at the molecular level. Detailed biochemical information from tissue biopsies can also be provided from use of this technique. The use of Raman spectroscopy in breast cancer investigations over the past 10 years and more, including in the study of EMT, is reviewed in the present work also listing the corresponding Raman peaks reported in the literature in seeking to better facilitate identification of peaks of interest.
format	Article
author	Sabtu, Siti Norbaini Sani, S. F. Abdul Bradley, D. A. Looi, Lai Meng Osman, Zurina
author_facet	Sabtu, Siti Norbaini Sani, S. F. Abdul Bradley, D. A. Looi, Lai Meng Osman, Zurina
author_sort	Sabtu, Siti Norbaini
title	A review of the applications of Raman spectroscopy for breast cancer tissue diagnostic and their histopathological classification of epithelial to mesenchymal transition
title_short	A review of the applications of Raman spectroscopy for breast cancer tissue diagnostic and their histopathological classification of epithelial to mesenchymal transition
title_full	A review of the applications of Raman spectroscopy for breast cancer tissue diagnostic and their histopathological classification of epithelial to mesenchymal transition
title_fullStr	A review of the applications of Raman spectroscopy for breast cancer tissue diagnostic and their histopathological classification of epithelial to mesenchymal transition
title_full_unstemmed	A review of the applications of Raman spectroscopy for breast cancer tissue diagnostic and their histopathological classification of epithelial to mesenchymal transition
title_sort	review of the applications of raman spectroscopy for breast cancer tissue diagnostic and their histopathological classification of epithelial to mesenchymal transition
publisher	Wiley
publishDate	2020
url	http://eprints.um.edu.my/37248/
_version_	1761616814103592960
score	13.211869

A review of the applications of Raman spectroscopy for breast cancer tissue diagnostic and their histopathological classification of epithelial to mesenchymal transition

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