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An inverse association between the Mediterranean diet and bladder cancer risk: A pooled analysis of 13 cohort studies

Purpose The role of diet in bladder carcinogenesis has yet to be established. To date most studies have investigated dietary components individually, rather than as dietary patterns, which may provide stronger evidence for any influence of diet on bladder carcinogenesis. The Mediterranean diet has b...

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Main Authors:	Witlox, Willem J. A., van Osch, Frits H. M., Brinkman, Maree, Jochems, Sylvia, Goossens, Maria E., Weiderpass, Elisabete, White, Emily, van den Brandt, Piet A., Giles, Graham G., Milne, Roger L., Huybrechts, Inge, Adami, Hans-Olov, Bueno-de-Mesquita, Bas, Wesselius, Anke, Zeegers, Maurice P.
Format:	Article
Published:	Springer Heidelberg 2020
Subjects:	RC0254 Neoplasms. Tumors. Oncology (including Cancer) RD Surgery
Online Access:	http://eprints.um.edu.my/36941/
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spelling	my.um.eprints.369412024-11-07T06:16:45Z http://eprints.um.edu.my/36941/ An inverse association between the Mediterranean diet and bladder cancer risk: A pooled analysis of 13 cohort studies Witlox, Willem J. A. van Osch, Frits H. M. Brinkman, Maree Jochems, Sylvia Goossens, Maria E. Weiderpass, Elisabete White, Emily van den Brandt, Piet A. Giles, Graham G. Milne, Roger L. Huybrechts, Inge Adami, Hans-Olov Bueno-de-Mesquita, Bas Wesselius, Anke Zeegers, Maurice P. RC0254 Neoplasms. Tumors. Oncology (including Cancer) RD Surgery Purpose The role of diet in bladder carcinogenesis has yet to be established. To date most studies have investigated dietary components individually, rather than as dietary patterns, which may provide stronger evidence for any influence of diet on bladder carcinogenesis. The Mediterranean diet has been associated with many health benefits, but few studies have investigated its association with bladder cancer risk. Methods We investigated the potential association between the Mediterranean diet score (MDS) and risk of developing bladder cancer by pooling 13 prospective cohort studies included in the BLadder cancer Epidemiology and Nutritional Determinants (BLEND) study and applying a Cox regression analysis. Results Dietary data from 646,222 study participants, including 3639 incident bladder cancer cases, were analysed. We observed an inverse association between Mediterranean diet and bladder cancer risk (HRhigh 0.85 95% CI 0.77, 0.93]). When stratifying the results on non-muscle-invasive or muscle-invasive disease or sex the association remained similar and the HR estimate was consistently below 1.00 both for medium and high adherence to the Mediterranean diet. A consistent association was observed when disregarding fat or alcohol intake. Conclusion We found evidence that adherence to the Mediterranean diet was associated with reduced risk of developing bladder cancer, suggesting a positive effect of the diet as a whole and not just one component. Springer Heidelberg 2020-02 Article PeerReviewed Witlox, Willem J. A. and van Osch, Frits H. M. and Brinkman, Maree and Jochems, Sylvia and Goossens, Maria E. and Weiderpass, Elisabete and White, Emily and van den Brandt, Piet A. and Giles, Graham G. and Milne, Roger L. and Huybrechts, Inge and Adami, Hans-Olov and Bueno-de-Mesquita, Bas and Wesselius, Anke and Zeegers, Maurice P. (2020) An inverse association between the Mediterranean diet and bladder cancer risk: A pooled analysis of 13 cohort studies. European Journal of Nutrition, 59 (1). pp. 287-296. ISSN 1436-6207, DOI https://doi.org/10.1007/s00394-019-01907-8 <https://doi.org/10.1007/s00394-019-01907-8>. 10.1007/s00394-019-01907-8
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	RC0254 Neoplasms. Tumors. Oncology (including Cancer) RD Surgery
spellingShingle	RC0254 Neoplasms. Tumors. Oncology (including Cancer) RD Surgery Witlox, Willem J. A. van Osch, Frits H. M. Brinkman, Maree Jochems, Sylvia Goossens, Maria E. Weiderpass, Elisabete White, Emily van den Brandt, Piet A. Giles, Graham G. Milne, Roger L. Huybrechts, Inge Adami, Hans-Olov Bueno-de-Mesquita, Bas Wesselius, Anke Zeegers, Maurice P. An inverse association between the Mediterranean diet and bladder cancer risk: A pooled analysis of 13 cohort studies
description	Purpose The role of diet in bladder carcinogenesis has yet to be established. To date most studies have investigated dietary components individually, rather than as dietary patterns, which may provide stronger evidence for any influence of diet on bladder carcinogenesis. The Mediterranean diet has been associated with many health benefits, but few studies have investigated its association with bladder cancer risk. Methods We investigated the potential association between the Mediterranean diet score (MDS) and risk of developing bladder cancer by pooling 13 prospective cohort studies included in the BLadder cancer Epidemiology and Nutritional Determinants (BLEND) study and applying a Cox regression analysis. Results Dietary data from 646,222 study participants, including 3639 incident bladder cancer cases, were analysed. We observed an inverse association between Mediterranean diet and bladder cancer risk (HRhigh 0.85 95% CI 0.77, 0.93]). When stratifying the results on non-muscle-invasive or muscle-invasive disease or sex the association remained similar and the HR estimate was consistently below 1.00 both for medium and high adherence to the Mediterranean diet. A consistent association was observed when disregarding fat or alcohol intake. Conclusion We found evidence that adherence to the Mediterranean diet was associated with reduced risk of developing bladder cancer, suggesting a positive effect of the diet as a whole and not just one component.
format	Article
author	Witlox, Willem J. A. van Osch, Frits H. M. Brinkman, Maree Jochems, Sylvia Goossens, Maria E. Weiderpass, Elisabete White, Emily van den Brandt, Piet A. Giles, Graham G. Milne, Roger L. Huybrechts, Inge Adami, Hans-Olov Bueno-de-Mesquita, Bas Wesselius, Anke Zeegers, Maurice P.
author_facet	Witlox, Willem J. A. van Osch, Frits H. M. Brinkman, Maree Jochems, Sylvia Goossens, Maria E. Weiderpass, Elisabete White, Emily van den Brandt, Piet A. Giles, Graham G. Milne, Roger L. Huybrechts, Inge Adami, Hans-Olov Bueno-de-Mesquita, Bas Wesselius, Anke Zeegers, Maurice P.
author_sort	Witlox, Willem J. A.
title	An inverse association between the Mediterranean diet and bladder cancer risk: A pooled analysis of 13 cohort studies
title_short	An inverse association between the Mediterranean diet and bladder cancer risk: A pooled analysis of 13 cohort studies
title_full	An inverse association between the Mediterranean diet and bladder cancer risk: A pooled analysis of 13 cohort studies
title_fullStr	An inverse association between the Mediterranean diet and bladder cancer risk: A pooled analysis of 13 cohort studies
title_full_unstemmed	An inverse association between the Mediterranean diet and bladder cancer risk: A pooled analysis of 13 cohort studies
title_sort	inverse association between the mediterranean diet and bladder cancer risk: a pooled analysis of 13 cohort studies
publisher	Springer Heidelberg
publishDate	2020
url	http://eprints.um.edu.my/36941/
_version_	1816130388136820736
score	13.223943

An inverse association between the Mediterranean diet and bladder cancer risk: A pooled analysis of 13 cohort studies

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