Consumption of fish and long-chain n-3 polyunsaturated fatty acids is associated with reduced risk of colorectal cancer in a large European cohort
BACKGROUND & AIMS: There is an unclear association between intake of fish and long-chain n-3 polyunsaturated fatty acids (n-3 LC-PUFAs) and colorectal cancer (CRC). We examined the association between fish consumption, dietary and circulating levels of n-3 LC-PUFAs, and ratio of n-6:n-3 LC-PUFA...
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2020
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R Medicine (General) RC Internal medicine Aglago, Elom K. Huybrechts, Inge Murphy, Neil Casagrande, Corinne Nicolas, Genevieve Pischon, Tobias Fedirko, Veronika Severi, Gianluca Boutron-Ruault, Marie-Christine Fournier, Agnes Katzke, Verena Kuehn, Tilman Olsen, Anja Tjonneland, Anne Dahm, Christina C. Overvad, Kim Lasheras, Cristina Agudo, Antonio Sanchez, Maria-Jose Amiano, Pilar Maria Huerta, Jose Ardanaz, Eva Perez-Cornago, Aurora Trichopoulou, Antonia Karakatsani, Anna Martimianaki, Georgia Palli, Domenico Pala, Valeria Tumino, Rosario Naccarati, Alessio Panico, Salvatore Bueno-de-Mesquita, Bas May, Anne Derksen, Jeroen W. G. Hellstrand, Sophie Ohlsson, Bodil Wennberg, Maria Van Guelpen, Bethany Skeie, Guri Brustad, Magritt Weiderpass, Elisabete Cross, Amanda J. Ward, Heather Riboli, Elio Norat, Teresa Chajes, Veronique Gunter, Marc J. Consumption of fish and long-chain n-3 polyunsaturated fatty acids is associated with reduced risk of colorectal cancer in a large European cohort |
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BACKGROUND & AIMS: There is an unclear association between intake of fish and long-chain n-3 polyunsaturated fatty acids (n-3 LC-PUFAs) and colorectal cancer (CRC). We examined the association between fish consumption, dietary and circulating levels of n-3 LC-PUFAs, and ratio of n-6:n-3 LC-PUFA with CRC using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. METHODS: Dietary intake of fish (total, fatty/oily, lean/white) and n-3 LC-PUFA were estimated by food frequency questionnaires given to 521,324 participants in the EPIC study; among these, 6291 individuals developed CRC (median follow up, 14.9 years). Levels of phospholipid LC-PUFA were measured by gas chromatography in plasma samples from a sub-group of 461 CRC cases and 461 matched individuals without CRC (controls). Multivariable Cox proportional hazards and conditional logistic regression models were used to calculate hazard ratios (HRs) and odds ratios (ORs), respectively, with 95% CIs. RESULTS: Total intake of fish (HR for quintile 5 vs 1, 0.88; 95% CI, 0.80-0.96; P-trend = .005), fatty fish (HR for quintile 5 vs 1, 0.90; 95% CI, 0.82-0.98; P-trend = .009), and lean fish (HR for quintile 5 vs 1, 0.91; 95% CI, 0.83-1.00; P-trend = .016) were inversely associated with CRC incidence. Intake of total n-3 LC-PUFA (HR for quintile 5 vs 1, 0.86; 95% CI, 0.78-0.95; P-trend = .010) was also associated with reduced risk of CRC, whereas dietary ratio of n-6:n-3 LC-PUFA was associated with increased risk of CRC (HR for quintile 5 vs 1, 1.31; 95% CI, 1.18-1.45; P-trend < .001). Plasma levels of phospholipid n-3 LC-PUFA was not associated with overall CRC risk, but an inverse trend was observed for proximal compared with distal colon cancer (P-heterogeneity = .026). CONCLUSIONS: In an analysis of dietary patterns of participants in the EPIC study, we found regular consumption of fish, at recommended levels, to be associated with a lower risk of CRC, possibly through exposure to n-3 LC-PUFA. Levels of n-3 LC-PUFA in plasma were not associated with CRC risk, but there may be differences in risk at different regions of the colon. |
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Article |
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Aglago, Elom K. Huybrechts, Inge Murphy, Neil Casagrande, Corinne Nicolas, Genevieve Pischon, Tobias Fedirko, Veronika Severi, Gianluca Boutron-Ruault, Marie-Christine Fournier, Agnes Katzke, Verena Kuehn, Tilman Olsen, Anja Tjonneland, Anne Dahm, Christina C. Overvad, Kim Lasheras, Cristina Agudo, Antonio Sanchez, Maria-Jose Amiano, Pilar Maria Huerta, Jose Ardanaz, Eva Perez-Cornago, Aurora Trichopoulou, Antonia Karakatsani, Anna Martimianaki, Georgia Palli, Domenico Pala, Valeria Tumino, Rosario Naccarati, Alessio Panico, Salvatore Bueno-de-Mesquita, Bas May, Anne Derksen, Jeroen W. G. Hellstrand, Sophie Ohlsson, Bodil Wennberg, Maria Van Guelpen, Bethany Skeie, Guri Brustad, Magritt Weiderpass, Elisabete Cross, Amanda J. Ward, Heather Riboli, Elio Norat, Teresa Chajes, Veronique Gunter, Marc J. |
| author_facet |
Aglago, Elom K. Huybrechts, Inge Murphy, Neil Casagrande, Corinne Nicolas, Genevieve Pischon, Tobias Fedirko, Veronika Severi, Gianluca Boutron-Ruault, Marie-Christine Fournier, Agnes Katzke, Verena Kuehn, Tilman Olsen, Anja Tjonneland, Anne Dahm, Christina C. Overvad, Kim Lasheras, Cristina Agudo, Antonio Sanchez, Maria-Jose Amiano, Pilar Maria Huerta, Jose Ardanaz, Eva Perez-Cornago, Aurora Trichopoulou, Antonia Karakatsani, Anna Martimianaki, Georgia Palli, Domenico Pala, Valeria Tumino, Rosario Naccarati, Alessio Panico, Salvatore Bueno-de-Mesquita, Bas May, Anne Derksen, Jeroen W. G. Hellstrand, Sophie Ohlsson, Bodil Wennberg, Maria Van Guelpen, Bethany Skeie, Guri Brustad, Magritt Weiderpass, Elisabete Cross, Amanda J. Ward, Heather Riboli, Elio Norat, Teresa Chajes, Veronique Gunter, Marc J. |
| author_sort |
Aglago, Elom K. |
| title |
Consumption of fish and long-chain n-3 polyunsaturated fatty acids is associated with reduced risk of colorectal cancer in a large European cohort |
| title_short |
Consumption of fish and long-chain n-3 polyunsaturated fatty acids is associated with reduced risk of colorectal cancer in a large European cohort |
| title_full |
Consumption of fish and long-chain n-3 polyunsaturated fatty acids is associated with reduced risk of colorectal cancer in a large European cohort |
| title_fullStr |
Consumption of fish and long-chain n-3 polyunsaturated fatty acids is associated with reduced risk of colorectal cancer in a large European cohort |
| title_full_unstemmed |
Consumption of fish and long-chain n-3 polyunsaturated fatty acids is associated with reduced risk of colorectal cancer in a large European cohort |
| title_sort |
consumption of fish and long-chain n-3 polyunsaturated fatty acids is associated with reduced risk of colorectal cancer in a large european cohort |
| publisher |
Elsevier Science Inc |
| publishDate |
2020 |
| url |
http://eprints.um.edu.my/36826/ |
| _version_ |
1814933267178061824 |
| spelling |
my.um.eprints.368262024-11-06T01:48:07Z http://eprints.um.edu.my/36826/ Consumption of fish and long-chain n-3 polyunsaturated fatty acids is associated with reduced risk of colorectal cancer in a large European cohort Aglago, Elom K. Huybrechts, Inge Murphy, Neil Casagrande, Corinne Nicolas, Genevieve Pischon, Tobias Fedirko, Veronika Severi, Gianluca Boutron-Ruault, Marie-Christine Fournier, Agnes Katzke, Verena Kuehn, Tilman Olsen, Anja Tjonneland, Anne Dahm, Christina C. Overvad, Kim Lasheras, Cristina Agudo, Antonio Sanchez, Maria-Jose Amiano, Pilar Maria Huerta, Jose Ardanaz, Eva Perez-Cornago, Aurora Trichopoulou, Antonia Karakatsani, Anna Martimianaki, Georgia Palli, Domenico Pala, Valeria Tumino, Rosario Naccarati, Alessio Panico, Salvatore Bueno-de-Mesquita, Bas May, Anne Derksen, Jeroen W. G. Hellstrand, Sophie Ohlsson, Bodil Wennberg, Maria Van Guelpen, Bethany Skeie, Guri Brustad, Magritt Weiderpass, Elisabete Cross, Amanda J. Ward, Heather Riboli, Elio Norat, Teresa Chajes, Veronique Gunter, Marc J. R Medicine (General) RC Internal medicine BACKGROUND & AIMS: There is an unclear association between intake of fish and long-chain n-3 polyunsaturated fatty acids (n-3 LC-PUFAs) and colorectal cancer (CRC). We examined the association between fish consumption, dietary and circulating levels of n-3 LC-PUFAs, and ratio of n-6:n-3 LC-PUFA with CRC using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. METHODS: Dietary intake of fish (total, fatty/oily, lean/white) and n-3 LC-PUFA were estimated by food frequency questionnaires given to 521,324 participants in the EPIC study; among these, 6291 individuals developed CRC (median follow up, 14.9 years). Levels of phospholipid LC-PUFA were measured by gas chromatography in plasma samples from a sub-group of 461 CRC cases and 461 matched individuals without CRC (controls). Multivariable Cox proportional hazards and conditional logistic regression models were used to calculate hazard ratios (HRs) and odds ratios (ORs), respectively, with 95% CIs. RESULTS: Total intake of fish (HR for quintile 5 vs 1, 0.88; 95% CI, 0.80-0.96; P-trend = .005), fatty fish (HR for quintile 5 vs 1, 0.90; 95% CI, 0.82-0.98; P-trend = .009), and lean fish (HR for quintile 5 vs 1, 0.91; 95% CI, 0.83-1.00; P-trend = .016) were inversely associated with CRC incidence. Intake of total n-3 LC-PUFA (HR for quintile 5 vs 1, 0.86; 95% CI, 0.78-0.95; P-trend = .010) was also associated with reduced risk of CRC, whereas dietary ratio of n-6:n-3 LC-PUFA was associated with increased risk of CRC (HR for quintile 5 vs 1, 1.31; 95% CI, 1.18-1.45; P-trend < .001). Plasma levels of phospholipid n-3 LC-PUFA was not associated with overall CRC risk, but an inverse trend was observed for proximal compared with distal colon cancer (P-heterogeneity = .026). CONCLUSIONS: In an analysis of dietary patterns of participants in the EPIC study, we found regular consumption of fish, at recommended levels, to be associated with a lower risk of CRC, possibly through exposure to n-3 LC-PUFA. Levels of n-3 LC-PUFA in plasma were not associated with CRC risk, but there may be differences in risk at different regions of the colon. Elsevier Science Inc 2020-03 Article PeerReviewed Aglago, Elom K. and Huybrechts, Inge and Murphy, Neil and Casagrande, Corinne and Nicolas, Genevieve and Pischon, Tobias and Fedirko, Veronika and Severi, Gianluca and Boutron-Ruault, Marie-Christine and Fournier, Agnes and Katzke, Verena and Kuehn, Tilman and Olsen, Anja and Tjonneland, Anne and Dahm, Christina C. and Overvad, Kim and Lasheras, Cristina and Agudo, Antonio and Sanchez, Maria-Jose and Amiano, Pilar and Maria Huerta, Jose and Ardanaz, Eva and Perez-Cornago, Aurora and Trichopoulou, Antonia and Karakatsani, Anna and Martimianaki, Georgia and Palli, Domenico and Pala, Valeria and Tumino, Rosario and Naccarati, Alessio and Panico, Salvatore and Bueno-de-Mesquita, Bas and May, Anne and Derksen, Jeroen W. G. and Hellstrand, Sophie and Ohlsson, Bodil and Wennberg, Maria and Van Guelpen, Bethany and Skeie, Guri and Brustad, Magritt and Weiderpass, Elisabete and Cross, Amanda J. and Ward, Heather and Riboli, Elio and Norat, Teresa and Chajes, Veronique and Gunter, Marc J. (2020) Consumption of fish and long-chain n-3 polyunsaturated fatty acids is associated with reduced risk of colorectal cancer in a large European cohort. Clinical Gastroenterology and Hepatology, 18 (3). 654+. ISSN 1542-3565, DOI https://doi.org/10.1016/j.cgh.2019.06.031 <https://doi.org/10.1016/j.cgh.2019.06.031>. 10.1016/j.cgh.2019.06.031 |
| score |
13.211869 |