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A double-blind, randomized controlled trial of pre-incision wound infiltration using diclofenac versus bupivacaine for post-operative pain relief in open thyroid and parathyroid surgery

Pre-incision wound infiltration using NSAID is an alternative method to manage post-operative pain in surgery. It is postulated that NSAID delivered peripherally exerts efficient analgesic and anti-inflammatory effect with minimal systemic complication. This study explored the efficacy of using dicl...

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Main Authors: Loh, Jing Wen, Taib, Nur Aishah Mohd, Cheong, Yew Teik, Tin, Tin Su
Format: Article
Published: Springer Verlag (Germany) 2020
Subjects:
R Medicine
Online Access:http://eprints.um.edu.my/36811/
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spelling my.um.eprints.368112023-10-04T07:42:13Z http://eprints.um.edu.my/36811/ A double-blind, randomized controlled trial of pre-incision wound infiltration using diclofenac versus bupivacaine for post-operative pain relief in open thyroid and parathyroid surgery Loh, Jing Wen Taib, Nur Aishah Mohd Cheong, Yew Teik Tin, Tin Su R Medicine Pre-incision wound infiltration using NSAID is an alternative method to manage post-operative pain in surgery. It is postulated that NSAID delivered peripherally exerts efficient analgesic and anti-inflammatory effect with minimal systemic complication. This study explored the efficacy of using diclofenac for wound infiltration in open thyroidectomy and parathyroidectomy as compared to conventional agent, bupivacaine. Methodology The study was designed as a double-blind, randomized controlled trial involving 94 patients who underwent open thyroidectomy or parathyroidectomy in Hospital Pulau Pinang, Malaysia, from November 2015 to November 2016. The study compared the efficacy of pre-incision wound infiltration of diclofenac (n = 47) versus bupivacaine (n = 47) in post-operative pain relief. Wound infiltration is given prior to skin incision. Mean pain score at designated time interval within the 24-h post-operative period, time to first analgesia, total analgesic usage and total analgesic cost were assessed. Results Ninety-four patients were recruited with no dropouts. Mean age was 49.3 (SD = 14.2) with majority being female (74.5%). Ethnic distribution recorded 42.6% Chinese, 38.3% Malay, followed by 19.1% Indian. Mean duration of surgery was 123.8 min (SD = 56.5), and mean length of hospital stay was 4.7 days (SD = 1.8). The characteristics of patient in both groups were generally comparable except that there were more cases of total thyroidectomy in the diclofenac group (n = 31) as compared to the bupivacaine group (n = 16). Mean pain score peaked at immediate post-operative period (post-operative 0.5 h) with a score of 3.5 out of 10 and the level decreased steadily over the next 20 h starting from 4 h post-operatively. Pre-incision wound infiltration using diclofenac had better pain control as compared to bupivacaine at all time interval assessed. In the resting state, the mean post-operative pain score difference was statistically significant at 2 h 2.1 (SD = 1.5) vs. 2.8 (SD = 1.8), p = 0.04]. During neck movement, the dynamic pain score difference was statistically significant at post-operative 1 h 2.7 (SD = 1.9) vs. 3.7 (SD = 2.1), p = 0.02]; 2 h 2.7 (SD = 1.6) vs. 3.7 (SD = 2.0), p = 0.01]; 4 h 2.2 (SD = 1.5) vs. 2.9 (SD = 1.7), p = 0.04], 6 h 1.9 (SD = 1.4) vs. 2.5 (SD = 1.6), p = 0.04] and 12 h 1.5 (SD = 1.5) vs. 2.2 (SD = 1.4), p = 0.03]. Mean dose of tramadol used as rescue analgesia in 24 h duration was lower in the diclofenac group as compared to bupivacaine group 13.8 mg (SD = 24.9) vs. 36.2 mg (SD = 45.1), p = 0.01]. The total cost of analgesia used was significantly cheaper in diclofenac group as compared to bupivacaine group RM 3.47 (SD = 1.51) vs. RM 13.43 (SD = 1.68), p < 0.01] or USD 0.83 (SD = 0.36) vs. USD 3.21 (SD = 0.40), p < 0.01]. Conclusion Pre-incision wound infiltration using diclofenac provides better post-operative pain relief compared to bupivacaine for patient who had underwent open thyroidectomy or parathyroidectomy. Diclofenac is cheap and easily available in the limited resource setting. This approach offers a superior alternative for post-operative pain relief as compared to bupivacaine. Springer Verlag (Germany) 2020-08 Article PeerReviewed Loh, Jing Wen and Taib, Nur Aishah Mohd and Cheong, Yew Teik and Tin, Tin Su (2020) A double-blind, randomized controlled trial of pre-incision wound infiltration using diclofenac versus bupivacaine for post-operative pain relief in open thyroid and parathyroid surgery. World Journal of Surgery, 44 (8). pp. 2656-2666. ISSN 0364-2313, DOI https://doi.org/10.1007/s00268-020-05458-6 <https://doi.org/10.1007/s00268-020-05458-6>. 10.1007/s00268-020-05458-6
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic R Medicine
spellingShingle R Medicine
Loh, Jing Wen
Taib, Nur Aishah Mohd
Cheong, Yew Teik
Tin, Tin Su
A double-blind, randomized controlled trial of pre-incision wound infiltration using diclofenac versus bupivacaine for post-operative pain relief in open thyroid and parathyroid surgery
description Pre-incision wound infiltration using NSAID is an alternative method to manage post-operative pain in surgery. It is postulated that NSAID delivered peripherally exerts efficient analgesic and anti-inflammatory effect with minimal systemic complication. This study explored the efficacy of using diclofenac for wound infiltration in open thyroidectomy and parathyroidectomy as compared to conventional agent, bupivacaine. Methodology The study was designed as a double-blind, randomized controlled trial involving 94 patients who underwent open thyroidectomy or parathyroidectomy in Hospital Pulau Pinang, Malaysia, from November 2015 to November 2016. The study compared the efficacy of pre-incision wound infiltration of diclofenac (n = 47) versus bupivacaine (n = 47) in post-operative pain relief. Wound infiltration is given prior to skin incision. Mean pain score at designated time interval within the 24-h post-operative period, time to first analgesia, total analgesic usage and total analgesic cost were assessed. Results Ninety-four patients were recruited with no dropouts. Mean age was 49.3 (SD = 14.2) with majority being female (74.5%). Ethnic distribution recorded 42.6% Chinese, 38.3% Malay, followed by 19.1% Indian. Mean duration of surgery was 123.8 min (SD = 56.5), and mean length of hospital stay was 4.7 days (SD = 1.8). The characteristics of patient in both groups were generally comparable except that there were more cases of total thyroidectomy in the diclofenac group (n = 31) as compared to the bupivacaine group (n = 16). Mean pain score peaked at immediate post-operative period (post-operative 0.5 h) with a score of 3.5 out of 10 and the level decreased steadily over the next 20 h starting from 4 h post-operatively. Pre-incision wound infiltration using diclofenac had better pain control as compared to bupivacaine at all time interval assessed. In the resting state, the mean post-operative pain score difference was statistically significant at 2 h 2.1 (SD = 1.5) vs. 2.8 (SD = 1.8), p = 0.04]. During neck movement, the dynamic pain score difference was statistically significant at post-operative 1 h 2.7 (SD = 1.9) vs. 3.7 (SD = 2.1), p = 0.02]; 2 h 2.7 (SD = 1.6) vs. 3.7 (SD = 2.0), p = 0.01]; 4 h 2.2 (SD = 1.5) vs. 2.9 (SD = 1.7), p = 0.04], 6 h 1.9 (SD = 1.4) vs. 2.5 (SD = 1.6), p = 0.04] and 12 h 1.5 (SD = 1.5) vs. 2.2 (SD = 1.4), p = 0.03]. Mean dose of tramadol used as rescue analgesia in 24 h duration was lower in the diclofenac group as compared to bupivacaine group 13.8 mg (SD = 24.9) vs. 36.2 mg (SD = 45.1), p = 0.01]. The total cost of analgesia used was significantly cheaper in diclofenac group as compared to bupivacaine group RM 3.47 (SD = 1.51) vs. RM 13.43 (SD = 1.68), p < 0.01] or USD 0.83 (SD = 0.36) vs. USD 3.21 (SD = 0.40), p < 0.01]. Conclusion Pre-incision wound infiltration using diclofenac provides better post-operative pain relief compared to bupivacaine for patient who had underwent open thyroidectomy or parathyroidectomy. Diclofenac is cheap and easily available in the limited resource setting. This approach offers a superior alternative for post-operative pain relief as compared to bupivacaine.
format Article
author Loh, Jing Wen
Taib, Nur Aishah Mohd
Cheong, Yew Teik
Tin, Tin Su
author_facet Loh, Jing Wen
Taib, Nur Aishah Mohd
Cheong, Yew Teik
Tin, Tin Su
author_sort Loh, Jing Wen
title A double-blind, randomized controlled trial of pre-incision wound infiltration using diclofenac versus bupivacaine for post-operative pain relief in open thyroid and parathyroid surgery
title_short A double-blind, randomized controlled trial of pre-incision wound infiltration using diclofenac versus bupivacaine for post-operative pain relief in open thyroid and parathyroid surgery
title_full A double-blind, randomized controlled trial of pre-incision wound infiltration using diclofenac versus bupivacaine for post-operative pain relief in open thyroid and parathyroid surgery
title_fullStr A double-blind, randomized controlled trial of pre-incision wound infiltration using diclofenac versus bupivacaine for post-operative pain relief in open thyroid and parathyroid surgery
title_full_unstemmed A double-blind, randomized controlled trial of pre-incision wound infiltration using diclofenac versus bupivacaine for post-operative pain relief in open thyroid and parathyroid surgery
title_sort double-blind, randomized controlled trial of pre-incision wound infiltration using diclofenac versus bupivacaine for post-operative pain relief in open thyroid and parathyroid surgery
publisher Springer Verlag (Germany)
publishDate 2020
url http://eprints.um.edu.my/36811/
_version_ 1781704500399046656
score 13.211869

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