Staff View: Clinical and genetic predictors of secondary sulfonylurea failure in Type 2 diabetes patients: the SUCLINGEN study

Clinical and genetic predictors of secondary sulfonylurea failure in Type 2 diabetes patients: the SUCLINGEN study

Background: Due to several limitations in the study designs of sulfonylurea pharmacogenomics studies, we investigated the clinical and genetic predictors of secondary sulfonylurea failure in Type 2 diabetes patients. Materials & methods: Patients receiving the maximum sulfonylurea and metformin...

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Main Authors:	Loganadan, Navin Kumar, Huri, Hasniza Zaman, Vethakkan, Shireene Ratna, Hussein, Zanariah
Format:	Article
Published:	Future Medicine Ltd. 2020
Subjects:	R Medicine (General) RC Internal medicine
Online Access:	http://eprints.um.edu.my/36660/
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spelling	my.um.eprints.366602023-12-01T02:09:39Z http://eprints.um.edu.my/36660/ Clinical and genetic predictors of secondary sulfonylurea failure in Type 2 diabetes patients: the SUCLINGEN study Loganadan, Navin Kumar Huri, Hasniza Zaman Vethakkan, Shireene Ratna Hussein, Zanariah R Medicine (General) RC Internal medicine Background: Due to several limitations in the study designs of sulfonylurea pharmacogenomics studies, we investigated the clinical and genetic predictors of secondary sulfonylurea failure in Type 2 diabetes patients. Materials & methods: Patients receiving the maximum sulfonylurea and metformin doses for >1 year were enrolled. Secondary sulfonylurea failure was defined as HbA1c >7.0% (>53 mmol/mol) after a 12-month follow-up. Results: By multivariate analysis, increased insulin resistance (HOMA2-IR), baseline HbA1c >7.0%, residing in eastern Peninsular Malaysia, and the CC genotype of rs757110 ABCC8 gene polymorphism were independent predictors of secondary sulfonylurea failure (p < 0.05) while sulfonylurea-induced hypoglycemia was protective against such failure (p < 0.05). Conclusion: Sulfonylurea does not benefit patients with an increased risk of secondary sulfonylurea failure. Future Medicine Ltd. 2020-06 Article PeerReviewed Loganadan, Navin Kumar and Huri, Hasniza Zaman and Vethakkan, Shireene Ratna and Hussein, Zanariah (2020) Clinical and genetic predictors of secondary sulfonylurea failure in Type 2 diabetes patients: the SUCLINGEN study. Pharmacogenomics, 21 (9). pp. 587-600. ISSN 1462-2416, DOI https://doi.org/10.2217/pgs-2019-0171 <https://doi.org/10.2217/pgs-2019-0171>. 10.2217/pgs-2019-0171
institution	Universiti Malaya
building	UM Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaya
content_source	UM Research Repository
url_provider	http://eprints.um.edu.my/
topic	R Medicine (General) RC Internal medicine
spellingShingle	R Medicine (General) RC Internal medicine Loganadan, Navin Kumar Huri, Hasniza Zaman Vethakkan, Shireene Ratna Hussein, Zanariah Clinical and genetic predictors of secondary sulfonylurea failure in Type 2 diabetes patients: the SUCLINGEN study
description	Background: Due to several limitations in the study designs of sulfonylurea pharmacogenomics studies, we investigated the clinical and genetic predictors of secondary sulfonylurea failure in Type 2 diabetes patients. Materials & methods: Patients receiving the maximum sulfonylurea and metformin doses for >1 year were enrolled. Secondary sulfonylurea failure was defined as HbA1c >7.0% (>53 mmol/mol) after a 12-month follow-up. Results: By multivariate analysis, increased insulin resistance (HOMA2-IR), baseline HbA1c >7.0%, residing in eastern Peninsular Malaysia, and the CC genotype of rs757110 ABCC8 gene polymorphism were independent predictors of secondary sulfonylurea failure (p < 0.05) while sulfonylurea-induced hypoglycemia was protective against such failure (p < 0.05). Conclusion: Sulfonylurea does not benefit patients with an increased risk of secondary sulfonylurea failure.
format	Article
author	Loganadan, Navin Kumar Huri, Hasniza Zaman Vethakkan, Shireene Ratna Hussein, Zanariah
author_facet	Loganadan, Navin Kumar Huri, Hasniza Zaman Vethakkan, Shireene Ratna Hussein, Zanariah
author_sort	Loganadan, Navin Kumar
title	Clinical and genetic predictors of secondary sulfonylurea failure in Type 2 diabetes patients: the SUCLINGEN study
title_short	Clinical and genetic predictors of secondary sulfonylurea failure in Type 2 diabetes patients: the SUCLINGEN study
title_full	Clinical and genetic predictors of secondary sulfonylurea failure in Type 2 diabetes patients: the SUCLINGEN study
title_fullStr	Clinical and genetic predictors of secondary sulfonylurea failure in Type 2 diabetes patients: the SUCLINGEN study
title_full_unstemmed	Clinical and genetic predictors of secondary sulfonylurea failure in Type 2 diabetes patients: the SUCLINGEN study
title_sort	clinical and genetic predictors of secondary sulfonylurea failure in type 2 diabetes patients: the suclingen study
publisher	Future Medicine Ltd.
publishDate	2020
url	http://eprints.um.edu.my/36660/
_version_	1784511830449717248
score	13.211869

Clinical and genetic predictors of secondary sulfonylurea failure in Type 2 diabetes patients: the SUCLINGEN study

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